Hsp60/chaperonin gene expression and differentiation of human colon adenocarcinoma and multipotent leukaemic cells
| ISSN: |
0006-291X
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|---|---|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
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| Topics: |
Biology
Chemistry and Pharmacology
Physics
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798292225744961539 |
|---|---|
| autor | Xiang, L. Seligy, V.L. |
| autorsonst | Xiang, L. Seligy, V.L. |
| book_url | http://dx.doi.org/10.1016/S0006-291X(05)80817-4 |
| datenlieferant | nat_lic_papers |
| fussnote | Elevated mitochondrial gene expression is an early event in the switch from proliferation to differentiation of the human colon adenocarcinoma cell line, HT29, promoted by trehalose replacement of exogenous glucose (1). Here we report the isolation and elevated expression of hsp60, the gene encoding chaperonin, a mitochondrial protein required for assembly of mitochondrial and cellular proteins. In contrast to HT29, leukaemic cells (HL60 and K562) neither differentiated nor altered their mitochondrial gene expression after treatment with trehalose. However, differentiation of these cells, as promoted by 12-O-tetradecanoylphorbol-13-acetate actually resulted in decreased levels of hsp60 mRNA expression as well as mitochondrial RNA expression, suggesting significant differences in involvement of mitochondria in the differentiation of these cell lineages. |
| hauptsatz | hsatz_simple |
| identnr | NLZ176938311 |
| issn | 0006-291X |
| journal_name | Biochemical and Biophysical Research Communications |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 186 (1992), S. 371-377 |
| search_space | articles |
| shingle_author_1 | Xiang, L. Seligy, V.L. |
| shingle_author_2 | Xiang, L. Seligy, V.L. |
| shingle_author_3 | Xiang, L. Seligy, V.L. |
| shingle_author_4 | Xiang, L. Seligy, V.L. |
| shingle_catch_all_1 | Xiang, L. Seligy, V.L. Hsp60/chaperonin gene expression and differentiation of human colon adenocarcinoma and multipotent leukaemic cells 0006-291X 0006291X Elsevier |
| shingle_catch_all_2 | Xiang, L. Seligy, V.L. Hsp60/chaperonin gene expression and differentiation of human colon adenocarcinoma and multipotent leukaemic cells 0006-291X 0006291X Elsevier |
| shingle_catch_all_3 | Xiang, L. Seligy, V.L. Hsp60/chaperonin gene expression and differentiation of human colon adenocarcinoma and multipotent leukaemic cells 0006-291X 0006291X Elsevier |
| shingle_catch_all_4 | Xiang, L. Seligy, V.L. Hsp60/chaperonin gene expression and differentiation of human colon adenocarcinoma and multipotent leukaemic cells 0006-291X 0006291X Elsevier |
| shingle_title_1 | Hsp60/chaperonin gene expression and differentiation of human colon adenocarcinoma and multipotent leukaemic cells |
| shingle_title_2 | Hsp60/chaperonin gene expression and differentiation of human colon adenocarcinoma and multipotent leukaemic cells |
| shingle_title_3 | Hsp60/chaperonin gene expression and differentiation of human colon adenocarcinoma and multipotent leukaemic cells |
| shingle_title_4 | Hsp60/chaperonin gene expression and differentiation of human colon adenocarcinoma and multipotent leukaemic cells |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:45:08.745Z |
| titel | Hsp60/chaperonin gene expression and differentiation of human colon adenocarcinoma and multipotent leukaemic cells |
| titel_suche | Hsp60/chaperonin gene expression and differentiation of human colon adenocarcinoma and multipotent leukaemic cells Elevated mitochondrial gene expression is an early event in the switch from proliferation to differentiation of the human colon adenocarcinoma cell line, HT29, promoted by trehalose replacement of exogenous glucose (1). Here we report the isolation and elevated expression of hsp60, the gene encoding chaperonin, a mitochondrial protein required for assembly of mitochondrial and cellular proteins. In contrast to HT29, leukaemic cells (HL60 and K562) neither differentiated nor altered their mitochondrial gene expression after treatment with trehalose. However, differentiation of these cells, as promoted by 12-O-tetradecanoylphorbol-13-acetate actually resulted in decreased levels of hsp60 mRNA expression as well as mitochondrial RNA expression, suggesting significant differences in involvement of mitochondria in the differentiation of these cell lineages. |
| topic | W V U |
| uid | nat_lic_papers_NLZ176938311 |