Genetic polymorphism of cytochrome P4502E1 in a Swedish population - Relationship to incidence of lung cancer
Persson, I. ; Johansson, I. ; Bergung, H. ; Dahl, M.-L. ; Seidegard, J. ; Rylander, R. ; Rannug, A. ; Hogberg, J. ; Sundberg, M.I.
Amsterdam : Elsevier
Amsterdam : Elsevier
| ISSN: |
0014-5793
|
|---|---|
| Keywords: |
Drug metabolism ; Ethanol ; Lung cancer ; Polymorphism
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| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
|
| Topics: |
Biology
Chemistry and Pharmacology
Physics
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798290826895294464 |
|---|---|
| autor | Persson, I. Johansson, I. Bergung, H. Dahl, M.-L. Seidegard, J. Rylander, R. Rannug, A. Hogberg, J. Sundberg, M.I. |
| autorsonst | Persson, I. Johansson, I. Bergung, H. Dahl, M.-L. Seidegard, J. Rylander, R. Rannug, A. Hogberg, J. Sundberg, M.I. |
| book_url | http://linkinghub.elsevier.com/retrieve/pii/0014-5793(93)80547-8 |
| datenlieferant | nat_lic_papers |
| fussnote | Genetic polymorphism of CYP2E1 was investigated among 195 Swedish patients with lung cancer and 206 controls. Three different polymorphic sites were found, all in introns, using RFLP and the restriction enzymes DraI, RsaI and TaqI. The frequencies of the rare alleles were 0.08-0.18 and much lower than previously described among Japanese. No significant difference in distribution of the polymorphic alleles between controls and lung cancer patients was evident, in contrast to results of a previous Japanese study. However, examination of a polymorphic site in the 5'-flanking region, within a putative binding motif for the hepatic transcription factor HNF-1, revealed a significantly less frequent distribution of the mutated allele (c"2) among the lung cancer patients as compared to controls. It is concluded that major interethnic differences exist in the genetic polymorphism of CYP2E1 and that people carrying the c"2 allele might be at lower risk for developing lung cancer. |
| hauptsatz | hsatz_simple |
| identnr | NLZ173287360 |
| issn | 0014-5793 |
| journal_name | FEBS Letters |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 319 (1993), S. 207-211 |
| schlagwort | Drug metabolism Ethanol Lung cancer Polymorphism |
| search_space | articles |
| shingle_author_1 | Persson, I. Johansson, I. Bergung, H. Dahl, M.-L. Seidegard, J. Rylander, R. Rannug, A. Hogberg, J. Sundberg, M.I. |
| shingle_author_2 | Persson, I. Johansson, I. Bergung, H. Dahl, M.-L. Seidegard, J. Rylander, R. Rannug, A. Hogberg, J. Sundberg, M.I. |
| shingle_author_3 | Persson, I. Johansson, I. Bergung, H. Dahl, M.-L. Seidegard, J. Rylander, R. Rannug, A. Hogberg, J. Sundberg, M.I. |
| shingle_author_4 | Persson, I. Johansson, I. Bergung, H. Dahl, M.-L. Seidegard, J. Rylander, R. Rannug, A. Hogberg, J. Sundberg, M.I. |
| shingle_catch_all_1 | Persson, I. Johansson, I. Bergung, H. Dahl, M.-L. Seidegard, J. Rylander, R. Rannug, A. Hogberg, J. Sundberg, M.I. Genetic polymorphism of cytochrome P4502E1 in a Swedish population - Relationship to incidence of lung cancer Drug metabolism Ethanol Lung cancer Polymorphism Drug metabolism Ethanol Lung cancer Polymorphism 0014-5793 00145793 Elsevier |
| shingle_catch_all_2 | Persson, I. Johansson, I. Bergung, H. Dahl, M.-L. Seidegard, J. Rylander, R. Rannug, A. Hogberg, J. Sundberg, M.I. Genetic polymorphism of cytochrome P4502E1 in a Swedish population - Relationship to incidence of lung cancer Drug metabolism Ethanol Lung cancer Polymorphism Drug metabolism Ethanol Lung cancer Polymorphism 0014-5793 00145793 Elsevier |
| shingle_catch_all_3 | Persson, I. Johansson, I. Bergung, H. Dahl, M.-L. Seidegard, J. Rylander, R. Rannug, A. Hogberg, J. Sundberg, M.I. Genetic polymorphism of cytochrome P4502E1 in a Swedish population - Relationship to incidence of lung cancer Drug metabolism Ethanol Lung cancer Polymorphism Drug metabolism Ethanol Lung cancer Polymorphism 0014-5793 00145793 Elsevier |
| shingle_catch_all_4 | Persson, I. Johansson, I. Bergung, H. Dahl, M.-L. Seidegard, J. Rylander, R. Rannug, A. Hogberg, J. Sundberg, M.I. Genetic polymorphism of cytochrome P4502E1 in a Swedish population - Relationship to incidence of lung cancer Drug metabolism Ethanol Lung cancer Polymorphism Drug metabolism Ethanol Lung cancer Polymorphism 0014-5793 00145793 Elsevier |
| shingle_title_1 | Genetic polymorphism of cytochrome P4502E1 in a Swedish population - Relationship to incidence of lung cancer |
| shingle_title_2 | Genetic polymorphism of cytochrome P4502E1 in a Swedish population - Relationship to incidence of lung cancer |
| shingle_title_3 | Genetic polymorphism of cytochrome P4502E1 in a Swedish population - Relationship to incidence of lung cancer |
| shingle_title_4 | Genetic polymorphism of cytochrome P4502E1 in a Swedish population - Relationship to incidence of lung cancer |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:22:54.790Z |
| titel | Genetic polymorphism of cytochrome P4502E1 in a Swedish population - Relationship to incidence of lung cancer |
| titel_suche | Genetic polymorphism of cytochrome P4502E1 in a Swedish population - Relationship to incidence of lung cancer Genetic polymorphism of CYP2E1 was investigated among 195 Swedish patients with lung cancer and 206 controls. Three different polymorphic sites were found, all in introns, using RFLP and the restriction enzymes DraI, RsaI and TaqI. The frequencies of the rare alleles were 0.08-0.18 and much lower than previously described among Japanese. No significant difference in distribution of the polymorphic alleles between controls and lung cancer patients was evident, in contrast to results of a previous Japanese study. However, examination of a polymorphic site in the 5'-flanking region, within a putative binding motif for the hepatic transcription factor HNF-1, revealed a significantly less frequent distribution of the mutated allele (c"2) among the lung cancer patients as compared to controls. It is concluded that major interethnic differences exist in the genetic polymorphism of CYP2E1 and that people carrying the c"2 allele might be at lower risk for developing lung cancer. |
| topic | W V U |
| uid | nat_lic_papers_NLZ173287360 |