Phospholipid peroxidation as a factor in gallstone pathogenesis
| ISSN: |
0014-5793
|
|---|---|
| Keywords: |
Cholesterol precipitation ; Gallstone ; Lipid peroxidation
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| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
|
| Topics: |
Biology
Chemistry and Pharmacology
Physics
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798290817790509056 |
|---|---|
| autor | Lichtenberg, D. Ragimova, S. Peled, Y. Halpern, Z. |
| autorsonst | Lichtenberg, D. Ragimova, S. Peled, Y. Halpern, Z. |
| book_url | http://linkinghub.elsevier.com/retrieve/pii/0014-5793(88)80612-4 |
| datenlieferant | nat_lic_papers |
| fussnote | Phospholipid peroxidation markedly reduces the stability of mixed micellar systems composed of cholate, phosphatidylcholine and supersaturating levels of cholesterol. This suggests that lipid peroxidation is likely to play a significant role in the precipitation of cholesterol from gallbladder bile, thus in the pathogenesis of cholesterol gallstones. This conclusion is supported by studies of the nucleation time of cholesterol in gallbladder biles, which was significantly reduced by exposure to a stream of oxygen. This effect of phospholipid peroxidation on cholesterol solubility may occur in other biological fluids as well. In view of the increased lipid peroxidation in the elderly, it may explain the effect of age on the frequency of various diseases related to cholesterol precipitation. |
| hauptsatz | hsatz_simple |
| identnr | NLZ17320967X |
| issn | 0014-5793 |
| journal_name | FEBS Letters |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 228 (1988), S. 179-181 |
| schlagwort | Cholesterol precipitation Gallstone Lipid peroxidation |
| search_space | articles |
| shingle_author_1 | Lichtenberg, D. Ragimova, S. Peled, Y. Halpern, Z. |
| shingle_author_2 | Lichtenberg, D. Ragimova, S. Peled, Y. Halpern, Z. |
| shingle_author_3 | Lichtenberg, D. Ragimova, S. Peled, Y. Halpern, Z. |
| shingle_author_4 | Lichtenberg, D. Ragimova, S. Peled, Y. Halpern, Z. |
| shingle_catch_all_1 | Lichtenberg, D. Ragimova, S. Peled, Y. Halpern, Z. Phospholipid peroxidation as a factor in gallstone pathogenesis Cholesterol precipitation Gallstone Lipid peroxidation Cholesterol precipitation Gallstone Lipid peroxidation 0014-5793 00145793 Elsevier |
| shingle_catch_all_2 | Lichtenberg, D. Ragimova, S. Peled, Y. Halpern, Z. Phospholipid peroxidation as a factor in gallstone pathogenesis Cholesterol precipitation Gallstone Lipid peroxidation Cholesterol precipitation Gallstone Lipid peroxidation 0014-5793 00145793 Elsevier |
| shingle_catch_all_3 | Lichtenberg, D. Ragimova, S. Peled, Y. Halpern, Z. Phospholipid peroxidation as a factor in gallstone pathogenesis Cholesterol precipitation Gallstone Lipid peroxidation Cholesterol precipitation Gallstone Lipid peroxidation 0014-5793 00145793 Elsevier |
| shingle_catch_all_4 | Lichtenberg, D. Ragimova, S. Peled, Y. Halpern, Z. Phospholipid peroxidation as a factor in gallstone pathogenesis Cholesterol precipitation Gallstone Lipid peroxidation Cholesterol precipitation Gallstone Lipid peroxidation 0014-5793 00145793 Elsevier |
| shingle_title_1 | Phospholipid peroxidation as a factor in gallstone pathogenesis |
| shingle_title_2 | Phospholipid peroxidation as a factor in gallstone pathogenesis |
| shingle_title_3 | Phospholipid peroxidation as a factor in gallstone pathogenesis |
| shingle_title_4 | Phospholipid peroxidation as a factor in gallstone pathogenesis |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:22:46.109Z |
| titel | Phospholipid peroxidation as a factor in gallstone pathogenesis |
| titel_suche | Phospholipid peroxidation as a factor in gallstone pathogenesis Phospholipid peroxidation markedly reduces the stability of mixed micellar systems composed of cholate, phosphatidylcholine and supersaturating levels of cholesterol. This suggests that lipid peroxidation is likely to play a significant role in the precipitation of cholesterol from gallbladder bile, thus in the pathogenesis of cholesterol gallstones. This conclusion is supported by studies of the nucleation time of cholesterol in gallbladder biles, which was significantly reduced by exposure to a stream of oxygen. This effect of phospholipid peroxidation on cholesterol solubility may occur in other biological fluids as well. In view of the increased lipid peroxidation in the elderly, it may explain the effect of age on the frequency of various diseases related to cholesterol precipitation. |
| topic | W V U |
| uid | nat_lic_papers_NLZ17320967X |