Microtubule-associated protein tau Identification of a novel peptide from bovine brain
| ISSN: |
0014-5793
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|---|---|
| Keywords: |
Amino acid sequencing ; Cyanogen bromide cleavage ; Microtubule ; Protein phosphorylation ; Protein, tau
|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
|
| Topics: |
Biology
Chemistry and Pharmacology
Physics
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798290817001979904 |
|---|---|
| autor | Iqbal, K. Smith, A.J. Zaidi, T. Grundke-Iqbal, I. |
| autorsonst | Iqbal, K. Smith, A.J. Zaidi, T. Grundke-Iqbal, I. |
| book_url | http://linkinghub.elsevier.com/retrieve/pii/0014-5793(89)80437-5 |
| datenlieferant | nat_lic_papers |
| fussnote | The microtubule-associated protein tau isolated from bovine brain was cleaved with CNBr and the 3 largest peptides of approx. 21, 19 and 18 kDa were obtained. Dephosphorylation of the CNBr digest of tau with alkaline phosphatase changed the electrophoretic mobility of these peptides to 19, 18 and 17 kDa. Amino acid sequencing of the total CNBr digest of tau revealed at least 3 sequences, two of which were highly homologous to previously published mouse and human tau sequences derived from cDNAs. A third amino acid sequence of 17 residues with heterogeneity at position 11 showed no homology with the cDNA-derived tau sequences. These studies suggest that the amino acid sequences of mammalian tau predicted from their cDNAs might be incomplete. |
| hauptsatz | hsatz_simple |
| identnr | NLZ173195687 |
| issn | 0014-5793 |
| journal_name | FEBS Letters |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 248 (1989), S. 87-91 |
| schlagwort | Amino acid sequencing Cyanogen bromide cleavage Microtubule Protein phosphorylation Protein, tau |
| search_space | articles |
| shingle_author_1 | Iqbal, K. Smith, A.J. Zaidi, T. Grundke-Iqbal, I. |
| shingle_author_2 | Iqbal, K. Smith, A.J. Zaidi, T. Grundke-Iqbal, I. |
| shingle_author_3 | Iqbal, K. Smith, A.J. Zaidi, T. Grundke-Iqbal, I. |
| shingle_author_4 | Iqbal, K. Smith, A.J. Zaidi, T. Grundke-Iqbal, I. |
| shingle_catch_all_1 | Iqbal, K. Smith, A.J. Zaidi, T. Grundke-Iqbal, I. Microtubule-associated protein tau Identification of a novel peptide from bovine brain Amino acid sequencing Cyanogen bromide cleavage Microtubule Protein phosphorylation Protein, tau Amino acid sequencing Cyanogen bromide cleavage Microtubule Protein phosphorylation Protein, tau 0014-5793 00145793 Elsevier |
| shingle_catch_all_2 | Iqbal, K. Smith, A.J. Zaidi, T. Grundke-Iqbal, I. Microtubule-associated protein tau Identification of a novel peptide from bovine brain Amino acid sequencing Cyanogen bromide cleavage Microtubule Protein phosphorylation Protein, tau Amino acid sequencing Cyanogen bromide cleavage Microtubule Protein phosphorylation Protein, tau 0014-5793 00145793 Elsevier |
| shingle_catch_all_3 | Iqbal, K. Smith, A.J. Zaidi, T. Grundke-Iqbal, I. Microtubule-associated protein tau Identification of a novel peptide from bovine brain Amino acid sequencing Cyanogen bromide cleavage Microtubule Protein phosphorylation Protein, tau Amino acid sequencing Cyanogen bromide cleavage Microtubule Protein phosphorylation Protein, tau 0014-5793 00145793 Elsevier |
| shingle_catch_all_4 | Iqbal, K. Smith, A.J. Zaidi, T. Grundke-Iqbal, I. Microtubule-associated protein tau Identification of a novel peptide from bovine brain Amino acid sequencing Cyanogen bromide cleavage Microtubule Protein phosphorylation Protein, tau Amino acid sequencing Cyanogen bromide cleavage Microtubule Protein phosphorylation Protein, tau 0014-5793 00145793 Elsevier |
| shingle_title_1 | Microtubule-associated protein tau Identification of a novel peptide from bovine brain |
| shingle_title_2 | Microtubule-associated protein tau Identification of a novel peptide from bovine brain |
| shingle_title_3 | Microtubule-associated protein tau Identification of a novel peptide from bovine brain |
| shingle_title_4 | Microtubule-associated protein tau Identification of a novel peptide from bovine brain |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:22:45.188Z |
| titel | Microtubule-associated protein tau Identification of a novel peptide from bovine brain |
| titel_suche | Microtubule-associated protein tau Identification of a novel peptide from bovine brain The microtubule-associated protein tau isolated from bovine brain was cleaved with CNBr and the 3 largest peptides of approx. 21, 19 and 18 kDa were obtained. Dephosphorylation of the CNBr digest of tau with alkaline phosphatase changed the electrophoretic mobility of these peptides to 19, 18 and 17 kDa. Amino acid sequencing of the total CNBr digest of tau revealed at least 3 sequences, two of which were highly homologous to previously published mouse and human tau sequences derived from cDNAs. A third amino acid sequence of 17 residues with heterogeneity at position 11 showed no homology with the cDNA-derived tau sequences. These studies suggest that the amino acid sequences of mammalian tau predicted from their cDNAs might be incomplete. |
| topic | W V U |
| uid | nat_lic_papers_NLZ173195687 |