Multiple sclerosis and mitochondrial myopathy: An unusual combination of diseases
Bet, L. ; Moggio, M. ; Comi, G. P. ; Mariani, C. ; Prelle, A. ; Checcarelli, N. ; Bordoni, A. ; Bresolin, N. ; Scarpini, E. ; Scarlato, G.
Springer
Published 1994
Springer
Published 1994
| ISSN: |
1432-1459
|
|---|---|
| Keywords: |
Multiple sclerosis ; Mitochondrial DNA (muscle) ; Mitochondrial myopathy
|
| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Medicine
|
| Notes: |
Abstract A woman with definite multiple sclerosis (MS) and mitochondrial myopathy is described. There were widespread white matter lesions on magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) abnormalities and evoked response changes. Muscle biopsy showed ragged red fibres (RRFs) and cytochrome c oxidase (CoX) deficiency. Southern blot analysis revealed a large deletion of mitochondrial DNA (mtDNA). The patient may be affected by two unrelated diseases, MS and mitochondrial myopathy, but this combination has never previously been reported.
|
| Type of Medium: |
Electronic Resource
|
| URL: |