Systemic and coronary hemodynamic effects of Abbott (40557) and its interaction with aminophylline
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1435-1803
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract Adenosine is a naturally occurring substance with potent coronary vasodilator action. However, its action is of short duration due to its rapid inactivation in blood and other tissues (1). If used for therapeutic purposes a prolonged duration of action might be desirable. A recent adenosine derivative (Abbott 40557) ethyl-adenosine-5′-carboxylate hydrochloride has marked and prolonged coronary vasodilator activity (2, 3). The present report concerns the coronary and systemic hemodynamic and metabolic effects of A 40557 and attempts to determine whether, like adenosine, its action is enhanced by dipyridamole (4, 5), hexobendine (6), and Cassella 7657 (7) or inhibited by aminophylline (8, 9).
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| Type of Medium: |
Electronic Resource
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