Effect of DNA polymerase inhibitors on the replication of human cytomegalovirus
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1432-8798
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Summary Aphidicolin, a specific inhibitor of cellular DNA polymerase α and of viral DNA polymerase, inhibits production of infectious virus and cellular and viral DNA synthesis of human cytomegalovirus (HCMV)-infected cells. On the other hand, 2′, 3′-dideoxynucleosides, inhibitors of DNA polymerases β and γ, do not affect HCMV replication. The data show that the α DNA polymerases of either viral or cellular origin are required for viral DNA synthesis, and cannot be substituted by the cellular DNA polymerase β and γ.
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| Type of Medium: |
Electronic Resource
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| URL: |