Detection of apoptosis induced in peripheral blood lymphocytes from cats infected with feline immunodeficiency virus
Momoi, Y. ; Mizuno, T. ; Nishimura, Y. ; Endo, Y. ; Ohno, K. ; Watari, T. ; Goitsuka, R. ; Tsujimoto, H. ; Hasegawa, A.
Springer
Published 1996
Springer
Published 1996
| ISSN: |
1432-8798
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Summary Peripheral blood lymphocytes (PBL) from cats infected with feline immunodeficiency virus (FIV) were examined for the occurrence of apoptosis after short-term culture. In the PBL from FIV-infected cats, changes in flow-cytometry scattergram, morphological characteristics of apoptosis and nucleosomal DNA fragmentation were observed. Percentages of apoptotic cells by flowcytometry analysis in PBL from FIV-infected cats (22.4%±9.4%) were significantly higher than those in PBL from uninfected control cats (9.2%±3.5%). The lymphocytes which underwent apoptosis included CD5+, CD4+ and sIgM+ cells, indicating that induction of apoptosis was not restricted to a special subset of lymphocytes. These findings provide evidence of the apoptotic state of PBL in cats with FIV infection.
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| Type of Medium: |
Electronic Resource
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| URL: |