Novel polymorphisms of prostate-specific antigen (PSA) gene associated with PSA mRNA expression in breast cancer
Yang, Q.-F. ; Sakurai, T. ; Shan, L. ; Yu, Z. ; Yoshimura, G. ; Suzuma, T. ; Tamaki, T. ; Umemura, T. ; Nakamura, M. ; Nakamura, Y. ; Mori, I. ; Kakudo, K.
Springer
Published 2000
Springer
Published 2000
| ISSN: |
1435-232X
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|---|---|
| Keywords: |
Key words Prostate-specific antigen gene ; Polymorphism ; Promoter ; Breast cancer ; Japanese ; Genotyping
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Biology
Medicine
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| Notes: |
Abstract A growing body of evidence suggests that prostate-specific antigen (PSA) is a novel prognostic factor for breast cancer. The molecular mechanism of variant PSA expression in breast cancer has remained poorly understood in spite of intensive research. Previous studies have shown that the coding region of the PSA gene is not a target for mutations in prostate cancer and breast cancer. The purpose of this study was to analyze genetic variations in the promoter region of the PSA gene, and to detect whether such variations are correlated with PSA mRNA expression in breast tumors. We identified two polymorphisms in the proximal promoter region of the PSA gene. These polymorphisms are located at positions −252 (G or A) and −205 (A or AA), and generate three genotypes. The genotypes were associated with PSA mRNA expression. Our findings suggest that these polymorphisms identified in the proximal promoter region may affect the transcriptional activity of PSA.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798297675260493824 |
|---|---|
| autor | Yang, Q.-F. Sakurai, T. Shan, L. Yu, Z. Yoshimura, G. Suzuma, T. Tamaki, T. Umemura, T. Nakamura, M. Nakamura, Y. Mori, I. Kakudo, K. |
| autorsonst | Yang, Q.-F. Sakurai, T. Shan, L. Yu, Z. Yoshimura, G. Suzuma, T. Tamaki, T. Umemura, T. Nakamura, M. Nakamura, Y. Mori, I. Kakudo, K. |
| book_url | http://dx.doi.org/10.1007/s100380070009 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM207696624 |
| issn | 1435-232X |
| journal_name | Journal of human genetics |
| materialart | 1 |
| notes | Abstract A growing body of evidence suggests that prostate-specific antigen (PSA) is a novel prognostic factor for breast cancer. The molecular mechanism of variant PSA expression in breast cancer has remained poorly understood in spite of intensive research. Previous studies have shown that the coding region of the PSA gene is not a target for mutations in prostate cancer and breast cancer. The purpose of this study was to analyze genetic variations in the promoter region of the PSA gene, and to detect whether such variations are correlated with PSA mRNA expression in breast tumors. We identified two polymorphisms in the proximal promoter region of the PSA gene. These polymorphisms are located at positions −252 (G or A) and −205 (A or AA), and generate three genotypes. The genotypes were associated with PSA mRNA expression. Our findings suggest that these polymorphisms identified in the proximal promoter region may affect the transcriptional activity of PSA. |
| package_name | Springer |
| publikationsjahr_anzeige | 2000 |
| publikationsjahr_facette | 2000 |
| publikationsjahr_intervall | 7999:2000-2004 |
| publikationsjahr_sort | 2000 |
| publisher | Springer |
| reference | 45 (2000), S. 363-366 |
| schlagwort | Key words Prostate-specific antigen gene Polymorphism Promoter Breast cancer Japanese Genotyping |
| search_space | articles |
| shingle_author_1 | Yang, Q.-F. Sakurai, T. Shan, L. Yu, Z. Yoshimura, G. Suzuma, T. Tamaki, T. Umemura, T. Nakamura, M. Nakamura, Y. Mori, I. Kakudo, K. |
| shingle_author_2 | Yang, Q.-F. Sakurai, T. Shan, L. Yu, Z. Yoshimura, G. Suzuma, T. Tamaki, T. Umemura, T. Nakamura, M. Nakamura, Y. Mori, I. Kakudo, K. |
| shingle_author_3 | Yang, Q.-F. Sakurai, T. Shan, L. Yu, Z. Yoshimura, G. Suzuma, T. Tamaki, T. Umemura, T. Nakamura, M. Nakamura, Y. Mori, I. Kakudo, K. |
| shingle_author_4 | Yang, Q.-F. Sakurai, T. Shan, L. Yu, Z. Yoshimura, G. Suzuma, T. Tamaki, T. Umemura, T. Nakamura, M. Nakamura, Y. Mori, I. Kakudo, K. |
| shingle_catch_all_1 | Yang, Q.-F. Sakurai, T. Shan, L. Yu, Z. Yoshimura, G. Suzuma, T. Tamaki, T. Umemura, T. Nakamura, M. Nakamura, Y. Mori, I. Kakudo, K. Novel polymorphisms of prostate-specific antigen (PSA) gene associated with PSA mRNA expression in breast cancer Key words Prostate-specific antigen gene Polymorphism Promoter Breast cancer Japanese Genotyping Key words Prostate-specific antigen gene Polymorphism Promoter Breast cancer Japanese Genotyping Abstract A growing body of evidence suggests that prostate-specific antigen (PSA) is a novel prognostic factor for breast cancer. The molecular mechanism of variant PSA expression in breast cancer has remained poorly understood in spite of intensive research. Previous studies have shown that the coding region of the PSA gene is not a target for mutations in prostate cancer and breast cancer. The purpose of this study was to analyze genetic variations in the promoter region of the PSA gene, and to detect whether such variations are correlated with PSA mRNA expression in breast tumors. We identified two polymorphisms in the proximal promoter region of the PSA gene. These polymorphisms are located at positions −252 (G or A) and −205 (A or AA), and generate three genotypes. The genotypes were associated with PSA mRNA expression. Our findings suggest that these polymorphisms identified in the proximal promoter region may affect the transcriptional activity of PSA. 1435-232X 1435232X Springer |
| shingle_catch_all_2 | Yang, Q.-F. Sakurai, T. Shan, L. Yu, Z. Yoshimura, G. Suzuma, T. Tamaki, T. Umemura, T. Nakamura, M. Nakamura, Y. Mori, I. Kakudo, K. Novel polymorphisms of prostate-specific antigen (PSA) gene associated with PSA mRNA expression in breast cancer Key words Prostate-specific antigen gene Polymorphism Promoter Breast cancer Japanese Genotyping Key words Prostate-specific antigen gene Polymorphism Promoter Breast cancer Japanese Genotyping Abstract A growing body of evidence suggests that prostate-specific antigen (PSA) is a novel prognostic factor for breast cancer. The molecular mechanism of variant PSA expression in breast cancer has remained poorly understood in spite of intensive research. Previous studies have shown that the coding region of the PSA gene is not a target for mutations in prostate cancer and breast cancer. The purpose of this study was to analyze genetic variations in the promoter region of the PSA gene, and to detect whether such variations are correlated with PSA mRNA expression in breast tumors. We identified two polymorphisms in the proximal promoter region of the PSA gene. These polymorphisms are located at positions −252 (G or A) and −205 (A or AA), and generate three genotypes. The genotypes were associated with PSA mRNA expression. Our findings suggest that these polymorphisms identified in the proximal promoter region may affect the transcriptional activity of PSA. 1435-232X 1435232X Springer |
| shingle_catch_all_3 | Yang, Q.-F. Sakurai, T. Shan, L. Yu, Z. Yoshimura, G. Suzuma, T. Tamaki, T. Umemura, T. Nakamura, M. Nakamura, Y. Mori, I. Kakudo, K. Novel polymorphisms of prostate-specific antigen (PSA) gene associated with PSA mRNA expression in breast cancer Key words Prostate-specific antigen gene Polymorphism Promoter Breast cancer Japanese Genotyping Key words Prostate-specific antigen gene Polymorphism Promoter Breast cancer Japanese Genotyping Abstract A growing body of evidence suggests that prostate-specific antigen (PSA) is a novel prognostic factor for breast cancer. The molecular mechanism of variant PSA expression in breast cancer has remained poorly understood in spite of intensive research. Previous studies have shown that the coding region of the PSA gene is not a target for mutations in prostate cancer and breast cancer. The purpose of this study was to analyze genetic variations in the promoter region of the PSA gene, and to detect whether such variations are correlated with PSA mRNA expression in breast tumors. We identified two polymorphisms in the proximal promoter region of the PSA gene. These polymorphisms are located at positions −252 (G or A) and −205 (A or AA), and generate three genotypes. The genotypes were associated with PSA mRNA expression. Our findings suggest that these polymorphisms identified in the proximal promoter region may affect the transcriptional activity of PSA. 1435-232X 1435232X Springer |
| shingle_catch_all_4 | Yang, Q.-F. Sakurai, T. Shan, L. Yu, Z. Yoshimura, G. Suzuma, T. Tamaki, T. Umemura, T. Nakamura, M. Nakamura, Y. Mori, I. Kakudo, K. Novel polymorphisms of prostate-specific antigen (PSA) gene associated with PSA mRNA expression in breast cancer Key words Prostate-specific antigen gene Polymorphism Promoter Breast cancer Japanese Genotyping Key words Prostate-specific antigen gene Polymorphism Promoter Breast cancer Japanese Genotyping Abstract A growing body of evidence suggests that prostate-specific antigen (PSA) is a novel prognostic factor for breast cancer. The molecular mechanism of variant PSA expression in breast cancer has remained poorly understood in spite of intensive research. Previous studies have shown that the coding region of the PSA gene is not a target for mutations in prostate cancer and breast cancer. The purpose of this study was to analyze genetic variations in the promoter region of the PSA gene, and to detect whether such variations are correlated with PSA mRNA expression in breast tumors. We identified two polymorphisms in the proximal promoter region of the PSA gene. These polymorphisms are located at positions −252 (G or A) and −205 (A or AA), and generate three genotypes. The genotypes were associated with PSA mRNA expression. Our findings suggest that these polymorphisms identified in the proximal promoter region may affect the transcriptional activity of PSA. 1435-232X 1435232X Springer |
| shingle_title_1 | Novel polymorphisms of prostate-specific antigen (PSA) gene associated with PSA mRNA expression in breast cancer |
| shingle_title_2 | Novel polymorphisms of prostate-specific antigen (PSA) gene associated with PSA mRNA expression in breast cancer |
| shingle_title_3 | Novel polymorphisms of prostate-specific antigen (PSA) gene associated with PSA mRNA expression in breast cancer |
| shingle_title_4 | Novel polymorphisms of prostate-specific antigen (PSA) gene associated with PSA mRNA expression in breast cancer |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T10:11:45.597Z |
| titel | Novel polymorphisms of prostate-specific antigen (PSA) gene associated with PSA mRNA expression in breast cancer |
| titel_suche | Novel polymorphisms of prostate-specific antigen (PSA) gene associated with PSA mRNA expression in breast cancer |
| topic | W WW-YZ |
| uid | nat_lic_papers_NLM207696624 |