Risk group stratification and prognostic factors in papillary carcinoma of thyroid
| ISSN: |
1534-4681
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|---|---|
| Keywords: |
Papillary carcinoma ; Thyroid ; Risk group stratification
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract Background: Our understanding of the natural history of differentiated thyroid carcinoma has improved with the definition of prognostic factors. These prognostic factors have helped us identify patients in various risk groups. Methods: A retrospective review of a consecutive series of 810 previously untreated patients with papillary carcinoma of the thyroid was undertaken to analyze the prognostic factors and risk groups. There were 403 patients in the low-risk group, 313 in the intermediate group, and 94 classified in the high-risk group. Results: With a median follow-up of 20 years, 99% survival was achieved in the low-risk group, whereas only 43% survived in the high-risk group. The intermediate-risk group had a 20-year survival of 83%. The favorable prognostic factors included female sex, young age, absence of distant metastases and extrathyroidal extension of the disease, size 〈4 cm, and low-grade histology. Focality, presence of lymph node metastasis, and pure papillary or mixed variant had no statistical significance on prognosis. Conclusions: Based on various prognostic factors, low-, intermediate-, and high-risk groups are identified. Patients in the low-risk group have excellent survival (99%). Appropriate selection of surgical and adjuvant treatment should therefore be used based on prognostic factors and risk group stratification.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798296347945730051 |
|---|---|
| autor | Shaha, Ashok R. Shah, Jatin P. Loree, Thom R. |
| autorsonst | Shaha, Ashok R. Shah, Jatin P. Loree, Thom R. |
| book_url | http://dx.doi.org/10.1007/BF02306085 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM207538573 |
| issn | 1534-4681 |
| journal_name | Annals of surgical oncology |
| materialart | 1 |
| notes | Abstract Background: Our understanding of the natural history of differentiated thyroid carcinoma has improved with the definition of prognostic factors. These prognostic factors have helped us identify patients in various risk groups. Methods: A retrospective review of a consecutive series of 810 previously untreated patients with papillary carcinoma of the thyroid was undertaken to analyze the prognostic factors and risk groups. There were 403 patients in the low-risk group, 313 in the intermediate group, and 94 classified in the high-risk group. Results: With a median follow-up of 20 years, 99% survival was achieved in the low-risk group, whereas only 43% survived in the high-risk group. The intermediate-risk group had a 20-year survival of 83%. The favorable prognostic factors included female sex, young age, absence of distant metastases and extrathyroidal extension of the disease, size 〈4 cm, and low-grade histology. Focality, presence of lymph node metastasis, and pure papillary or mixed variant had no statistical significance on prognosis. Conclusions: Based on various prognostic factors, low-, intermediate-, and high-risk groups are identified. Patients in the low-risk group have excellent survival (99%). Appropriate selection of surgical and adjuvant treatment should therefore be used based on prognostic factors and risk group stratification. |
| package_name | Springer |
| publikationsjahr_anzeige | 1996 |
| publikationsjahr_facette | 1996 |
| publikationsjahr_intervall | 8004:1995-1999 |
| publikationsjahr_sort | 1996 |
| publisher | Springer |
| reference | 3 (1996), S. 534-538 |
| schlagwort | Papillary carcinoma Thyroid Risk group stratification |
| search_space | articles |
| shingle_author_1 | Shaha, Ashok R. Shah, Jatin P. Loree, Thom R. |
| shingle_author_2 | Shaha, Ashok R. Shah, Jatin P. Loree, Thom R. |
| shingle_author_3 | Shaha, Ashok R. Shah, Jatin P. Loree, Thom R. |
| shingle_author_4 | Shaha, Ashok R. Shah, Jatin P. Loree, Thom R. |
| shingle_catch_all_1 | Shaha, Ashok R. Shah, Jatin P. Loree, Thom R. Risk group stratification and prognostic factors in papillary carcinoma of thyroid Papillary carcinoma Thyroid Risk group stratification Papillary carcinoma Thyroid Risk group stratification Abstract Background: Our understanding of the natural history of differentiated thyroid carcinoma has improved with the definition of prognostic factors. These prognostic factors have helped us identify patients in various risk groups. Methods: A retrospective review of a consecutive series of 810 previously untreated patients with papillary carcinoma of the thyroid was undertaken to analyze the prognostic factors and risk groups. There were 403 patients in the low-risk group, 313 in the intermediate group, and 94 classified in the high-risk group. Results: With a median follow-up of 20 years, 99% survival was achieved in the low-risk group, whereas only 43% survived in the high-risk group. The intermediate-risk group had a 20-year survival of 83%. The favorable prognostic factors included female sex, young age, absence of distant metastases and extrathyroidal extension of the disease, size 〈4 cm, and low-grade histology. Focality, presence of lymph node metastasis, and pure papillary or mixed variant had no statistical significance on prognosis. Conclusions: Based on various prognostic factors, low-, intermediate-, and high-risk groups are identified. Patients in the low-risk group have excellent survival (99%). Appropriate selection of surgical and adjuvant treatment should therefore be used based on prognostic factors and risk group stratification. 1534-4681 15344681 Springer |
| shingle_catch_all_2 | Shaha, Ashok R. Shah, Jatin P. Loree, Thom R. Risk group stratification and prognostic factors in papillary carcinoma of thyroid Papillary carcinoma Thyroid Risk group stratification Papillary carcinoma Thyroid Risk group stratification Abstract Background: Our understanding of the natural history of differentiated thyroid carcinoma has improved with the definition of prognostic factors. These prognostic factors have helped us identify patients in various risk groups. Methods: A retrospective review of a consecutive series of 810 previously untreated patients with papillary carcinoma of the thyroid was undertaken to analyze the prognostic factors and risk groups. There were 403 patients in the low-risk group, 313 in the intermediate group, and 94 classified in the high-risk group. Results: With a median follow-up of 20 years, 99% survival was achieved in the low-risk group, whereas only 43% survived in the high-risk group. The intermediate-risk group had a 20-year survival of 83%. The favorable prognostic factors included female sex, young age, absence of distant metastases and extrathyroidal extension of the disease, size 〈4 cm, and low-grade histology. Focality, presence of lymph node metastasis, and pure papillary or mixed variant had no statistical significance on prognosis. Conclusions: Based on various prognostic factors, low-, intermediate-, and high-risk groups are identified. Patients in the low-risk group have excellent survival (99%). Appropriate selection of surgical and adjuvant treatment should therefore be used based on prognostic factors and risk group stratification. 1534-4681 15344681 Springer |
| shingle_catch_all_3 | Shaha, Ashok R. Shah, Jatin P. Loree, Thom R. Risk group stratification and prognostic factors in papillary carcinoma of thyroid Papillary carcinoma Thyroid Risk group stratification Papillary carcinoma Thyroid Risk group stratification Abstract Background: Our understanding of the natural history of differentiated thyroid carcinoma has improved with the definition of prognostic factors. These prognostic factors have helped us identify patients in various risk groups. Methods: A retrospective review of a consecutive series of 810 previously untreated patients with papillary carcinoma of the thyroid was undertaken to analyze the prognostic factors and risk groups. There were 403 patients in the low-risk group, 313 in the intermediate group, and 94 classified in the high-risk group. Results: With a median follow-up of 20 years, 99% survival was achieved in the low-risk group, whereas only 43% survived in the high-risk group. The intermediate-risk group had a 20-year survival of 83%. The favorable prognostic factors included female sex, young age, absence of distant metastases and extrathyroidal extension of the disease, size 〈4 cm, and low-grade histology. Focality, presence of lymph node metastasis, and pure papillary or mixed variant had no statistical significance on prognosis. Conclusions: Based on various prognostic factors, low-, intermediate-, and high-risk groups are identified. Patients in the low-risk group have excellent survival (99%). Appropriate selection of surgical and adjuvant treatment should therefore be used based on prognostic factors and risk group stratification. 1534-4681 15344681 Springer |
| shingle_catch_all_4 | Shaha, Ashok R. Shah, Jatin P. Loree, Thom R. Risk group stratification and prognostic factors in papillary carcinoma of thyroid Papillary carcinoma Thyroid Risk group stratification Papillary carcinoma Thyroid Risk group stratification Abstract Background: Our understanding of the natural history of differentiated thyroid carcinoma has improved with the definition of prognostic factors. These prognostic factors have helped us identify patients in various risk groups. Methods: A retrospective review of a consecutive series of 810 previously untreated patients with papillary carcinoma of the thyroid was undertaken to analyze the prognostic factors and risk groups. There were 403 patients in the low-risk group, 313 in the intermediate group, and 94 classified in the high-risk group. Results: With a median follow-up of 20 years, 99% survival was achieved in the low-risk group, whereas only 43% survived in the high-risk group. The intermediate-risk group had a 20-year survival of 83%. The favorable prognostic factors included female sex, young age, absence of distant metastases and extrathyroidal extension of the disease, size 〈4 cm, and low-grade histology. Focality, presence of lymph node metastasis, and pure papillary or mixed variant had no statistical significance on prognosis. Conclusions: Based on various prognostic factors, low-, intermediate-, and high-risk groups are identified. Patients in the low-risk group have excellent survival (99%). Appropriate selection of surgical and adjuvant treatment should therefore be used based on prognostic factors and risk group stratification. 1534-4681 15344681 Springer |
| shingle_title_1 | Risk group stratification and prognostic factors in papillary carcinoma of thyroid |
| shingle_title_2 | Risk group stratification and prognostic factors in papillary carcinoma of thyroid |
| shingle_title_3 | Risk group stratification and prognostic factors in papillary carcinoma of thyroid |
| shingle_title_4 | Risk group stratification and prognostic factors in papillary carcinoma of thyroid |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:50:39.882Z |
| titel | Risk group stratification and prognostic factors in papillary carcinoma of thyroid |
| titel_suche | Risk group stratification and prognostic factors in papillary carcinoma of thyroid |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM207538573 |