The X-linked methylated DNA binding protein, Mecp2, is subject to X inactivation in the mouse
Adler, D. A. ; Quaderi, N. A. ; Brown, S. D. M. ; Chapman, V. M. ; Moore, J. ; Tate, P. ; Disteche, C. M.
Springer
Published 1995
Springer
Published 1995
| ISSN: |
1432-1777
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|---|---|
| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Biology
Medicine
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| Notes: |
Abstract DNA methylation at the promoter region of X-linked genes is associated with the maintenance of X inactivation in mammals. One of the methylated DNA binding proteins, MECP2, that binds to methylated bases in DNA is encoded by a gene (Mecp2) located on the mouse X Chromosome (Chr). To determine whether this gene was expressed from the inactive X Chr, and X-autosome translocation (T(X;16)16H) system in which expression from the Mecp2 allele on the inactive X Chr could be assayed was used. Results from these experiments indicate that Mecp2 is subject to X inactivation in mouse.
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| Type of Medium: |
Electronic Resource
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| URL: |