Synteny conservation of the Huntington's disease gene and surrounding loci on mouse Chromosome 5
Grosson, C. L. S. ; MacDonald, M. E. ; Duyao, M. P. ; Ambrose, C. M. ; Roffler-Tarlov, S. ; Gusella, J. F.
Springer
Published 1994
Springer
Published 1994
| ISSN: |
1432-1777
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Biology
Medicine
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| Notes: |
Abstract The mouse homologs of the Huntington's disease (HD) gene and 17 other human Chromosome (Chr) 4 loci (including six previously unmapped) were localized by use of an interspecific cross. All loci mapped in a continuous linkage group on mouse Chr 5, distal to En2 and Il6, whose human counterparts are located on Chr y. The relative order of the loci on human Chr 4 and mouse Chr 5 was maintained, except for a break between D5H4S115E and Idua/rd, with relocation of the latter to the opposite end of the map. The mouse HD homolog (Hdh) mapped within a cluster of seven genes that were completely linked in our data set. In human these loci span a∼1.8 Mb stretch of human 4p 16.3 that has been entirely cloned. To date, there is no phenotypic correspondence between human and mouse mutations mapping to this region of synteny conservation.
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| Type of Medium: |
Electronic Resource
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| URL: |