Low-Dose Cyclosporin for Multiple Colonic Ulcers Associated with Mixed Connective Tissue Disease
Maeda, N. ; Abe, S. ; Yoshizawa, T. ; Ogawa, K. ; Sekigawa, I. ; Iida, N. ; Eguchi, M. ; Matsumoto, M. ; Hashimoto, H. ; Hirose, S.
Springer
Published 1999
Springer
Published 1999
| ISSN: |
1434-9949
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|---|---|
| Keywords: |
Key words: Colonic ulcer – Cyclosporin – Mixed connective tissue disease
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract: This report describes a patient with multiple colonic ulcers and mixed connective tissue disease. The histological findings of the colonic lesions showed vasculitis with T-cell infiltration, and the peripheral T cells were frequently in the activated phase of the cell cycle. In this patient, low-dose cyclosporin treatment (2.5 mg/kg/day) inhibited the T-cell activation in the peripheral lymphocytes and was very effective in the gastrointestinal disorder, which might be related to T-cell activation. This case suggests the possibility that even low-dose cyclosporin can exert a great influence on peripheral T cells and directly inhibit T-cell activation, thereby improving symptoms related to T-cell activation.
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| Type of Medium: |
Electronic Resource
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| URL: |