Effects of glucocorticoids on skeletal growth in rabbits evaluated by dual-photon absorptiometry, microscopic connectivity and vertebral compressive strength
Grardel, B. ; Sutter, B. ; Flautre, B. ; Viguier, E. ; Lavaste, F. ; Hardouin, P.
Springer
Published 1994
Springer
Published 1994
| ISSN: |
1433-2965
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|---|---|
| Keywords: |
Bone histomorphometry ; Corticosteroid ; Dual-photon absorptiometry ; Mechanical testing ; Osteoporosis ; Rabbit
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract The effects of corticosteroid on bone were examined in female growing rabbits treated with 0.7 mg/kg per day prednisolone for 5 months. The evolution of whole-body total bone mineral measured by dual-photon absorptiometry showed a significant difference between the prednisolone-treated group and the control group from the first to the fifth month. The histomorphometric profile of corticosteroid-induced osteoporosis was observed, in particular the lower bone volume and thinner and fewer trabecular plates. Mechanical tests are possible on rabbit vertebrae and showed a very significant difference in bone strength between the prednisolone-treated and control groups, and a good correlation between mechanical tests and histomorphometric or densitometric results. This bone corticosteroid model shows that vertebral compression tests are possible on rabbit lumbar vertebrae. It may contribute to a better evaluation of corticosteroid treatments.
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| Type of Medium: |
Electronic Resource
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| URL: |