Comparative in vitro activity of norfloxacin against resistantNeisseria gonorrhoeae

1435-4373

Springer Online Journal Archives 1860-2000

Medicine

Abstract The in vitro activity of seven antibiotics against 52 isolates ofNeisseria gonorrhoeae was determined. Against penicillinase-producingNeisseria gonorrhoeae, ceftriaxone was the most active agent (MIC90 0.015 µg/ml), followed by ceftizoxime and norfloxacin (MIC90 0.03–0.125 µg/ml). Against spectinomycin-resistantNeisseria gonorrhoeae, the most active agents were ceftizoxime, ceftriaxone and norfloxacin (MIC90 0.015–0.125 µg/ml). Ceftizoxime, ceftriaxone and norfloxacin were also the most active agents against tetracycline-resistantNeisseria gonorrhoeae (MIC90 0.06–0.125 µg/ml). Overall, the rank order of activity from the most to the least active agent was as follows: ceftizoxime (MIC90 0.015 µg/ml); ceftriaxone (MIC90 0.06 µg/ml); norfloxacin (MIC90 0.125 µg/ml); cefoxitin (MIC90 2 µg/ml); tetracycline (MIC90 8 µg/ml); penicillin (MIC90 〉 8 µg/ml); and spectinomycin (MIC90 〉 128 µg/ml).

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