Genetic Determinants of Pseudomonas aeruginosa Colonization in Cystic Fibrosis Patients in Canada

ISSN:
1435-4373
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract  The present study was aimed at analyzing whether the rate of colonization and the age at colonization with Pseudomonas aeruginosa was genetically determined in cystic fibrosis (CF) patients. These two variables were calculated among 127 CF patients whose genotypes were known and who were monitored at the Clinique de Fibrose Kystique in Saguenay Lac-Saint-Jean. No statistically significant differences were found in the rate or the age at colonization when the patients were grouped by genotype; however, this result could be due to the small number of patients in each genotype group. The rate of colonization was significantly lower among CF patients carrying the A455E mutation, a "mild" allele with respect to exocrine pancreatic function, than among those carrying either the ΔF508 or the 621+1G-〉T mutation, both of which are "severe" alleles. The results confirm previous reports that the rate of colonization with Pseudomonas aeruginosa is, at least in part, genetically determined.
Type of Medium:
Electronic Resource
URL:
_version_ 1798296204934643712
autor Braekeleer, M. De
Allard, C.
Leblanc, J.-P.
Aubin, G.
Simard, F.
autorsonst Braekeleer, M. De
Allard, C.
Leblanc, J.-P.
Aubin, G.
Simard, F.
book_url http://dx.doi.org/10.1007/BF01699984
datenlieferant nat_lic_papers
hauptsatz hsatz_simple
identnr NLM206291418
issn 1435-4373
journal_name European journal of clinical microbiology & infectious diseases
materialart 1
notes Abstract  The present study was aimed at analyzing whether the rate of colonization and the age at colonization with Pseudomonas aeruginosa was genetically determined in cystic fibrosis (CF) patients. These two variables were calculated among 127 CF patients whose genotypes were known and who were monitored at the Clinique de Fibrose Kystique in Saguenay Lac-Saint-Jean. No statistically significant differences were found in the rate or the age at colonization when the patients were grouped by genotype; however, this result could be due to the small number of patients in each genotype group. The rate of colonization was significantly lower among CF patients carrying the A455E mutation, a "mild" allele with respect to exocrine pancreatic function, than among those carrying either the ΔF508 or the 621+1G-〉T mutation, both of which are "severe" alleles. The results confirm previous reports that the rate of colonization with Pseudomonas aeruginosa is, at least in part, genetically determined.
package_name Springer
publikationsjahr_anzeige 1998
publikationsjahr_facette 1998
publikationsjahr_intervall 8004:1995-1999
publikationsjahr_sort 1998
publisher Springer
reference 17 (1998), S. 269-271
search_space articles
shingle_author_1 Braekeleer, M. De
Allard, C.
Leblanc, J.-P.
Aubin, G.
Simard, F.
shingle_author_2 Braekeleer, M. De
Allard, C.
Leblanc, J.-P.
Aubin, G.
Simard, F.
shingle_author_3 Braekeleer, M. De
Allard, C.
Leblanc, J.-P.
Aubin, G.
Simard, F.
shingle_author_4 Braekeleer, M. De
Allard, C.
Leblanc, J.-P.
Aubin, G.
Simard, F.
shingle_catch_all_1 Braekeleer, M. De
Allard, C.
Leblanc, J.-P.
Aubin, G.
Simard, F.
Genetic Determinants of Pseudomonas aeruginosa Colonization in Cystic Fibrosis Patients in Canada
Abstract  The present study was aimed at analyzing whether the rate of colonization and the age at colonization with Pseudomonas aeruginosa was genetically determined in cystic fibrosis (CF) patients. These two variables were calculated among 127 CF patients whose genotypes were known and who were monitored at the Clinique de Fibrose Kystique in Saguenay Lac-Saint-Jean. No statistically significant differences were found in the rate or the age at colonization when the patients were grouped by genotype; however, this result could be due to the small number of patients in each genotype group. The rate of colonization was significantly lower among CF patients carrying the A455E mutation, a "mild" allele with respect to exocrine pancreatic function, than among those carrying either the ΔF508 or the 621+1G-〉T mutation, both of which are "severe" alleles. The results confirm previous reports that the rate of colonization with Pseudomonas aeruginosa is, at least in part, genetically determined.
1435-4373
14354373
Springer
shingle_catch_all_2 Braekeleer, M. De
Allard, C.
Leblanc, J.-P.
Aubin, G.
Simard, F.
Genetic Determinants of Pseudomonas aeruginosa Colonization in Cystic Fibrosis Patients in Canada
Abstract  The present study was aimed at analyzing whether the rate of colonization and the age at colonization with Pseudomonas aeruginosa was genetically determined in cystic fibrosis (CF) patients. These two variables were calculated among 127 CF patients whose genotypes were known and who were monitored at the Clinique de Fibrose Kystique in Saguenay Lac-Saint-Jean. No statistically significant differences were found in the rate or the age at colonization when the patients were grouped by genotype; however, this result could be due to the small number of patients in each genotype group. The rate of colonization was significantly lower among CF patients carrying the A455E mutation, a "mild" allele with respect to exocrine pancreatic function, than among those carrying either the ΔF508 or the 621+1G-〉T mutation, both of which are "severe" alleles. The results confirm previous reports that the rate of colonization with Pseudomonas aeruginosa is, at least in part, genetically determined.
1435-4373
14354373
Springer
shingle_catch_all_3 Braekeleer, M. De
Allard, C.
Leblanc, J.-P.
Aubin, G.
Simard, F.
Genetic Determinants of Pseudomonas aeruginosa Colonization in Cystic Fibrosis Patients in Canada
Abstract  The present study was aimed at analyzing whether the rate of colonization and the age at colonization with Pseudomonas aeruginosa was genetically determined in cystic fibrosis (CF) patients. These two variables were calculated among 127 CF patients whose genotypes were known and who were monitored at the Clinique de Fibrose Kystique in Saguenay Lac-Saint-Jean. No statistically significant differences were found in the rate or the age at colonization when the patients were grouped by genotype; however, this result could be due to the small number of patients in each genotype group. The rate of colonization was significantly lower among CF patients carrying the A455E mutation, a "mild" allele with respect to exocrine pancreatic function, than among those carrying either the ΔF508 or the 621+1G-〉T mutation, both of which are "severe" alleles. The results confirm previous reports that the rate of colonization with Pseudomonas aeruginosa is, at least in part, genetically determined.
1435-4373
14354373
Springer
shingle_catch_all_4 Braekeleer, M. De
Allard, C.
Leblanc, J.-P.
Aubin, G.
Simard, F.
Genetic Determinants of Pseudomonas aeruginosa Colonization in Cystic Fibrosis Patients in Canada
Abstract  The present study was aimed at analyzing whether the rate of colonization and the age at colonization with Pseudomonas aeruginosa was genetically determined in cystic fibrosis (CF) patients. These two variables were calculated among 127 CF patients whose genotypes were known and who were monitored at the Clinique de Fibrose Kystique in Saguenay Lac-Saint-Jean. No statistically significant differences were found in the rate or the age at colonization when the patients were grouped by genotype; however, this result could be due to the small number of patients in each genotype group. The rate of colonization was significantly lower among CF patients carrying the A455E mutation, a "mild" allele with respect to exocrine pancreatic function, than among those carrying either the ΔF508 or the 621+1G-〉T mutation, both of which are "severe" alleles. The results confirm previous reports that the rate of colonization with Pseudomonas aeruginosa is, at least in part, genetically determined.
1435-4373
14354373
Springer
shingle_title_1 Genetic Determinants of Pseudomonas aeruginosa Colonization in Cystic Fibrosis Patients in Canada
shingle_title_2 Genetic Determinants of Pseudomonas aeruginosa Colonization in Cystic Fibrosis Patients in Canada
shingle_title_3 Genetic Determinants of Pseudomonas aeruginosa Colonization in Cystic Fibrosis Patients in Canada
shingle_title_4 Genetic Determinants of Pseudomonas aeruginosa Colonization in Cystic Fibrosis Patients in Canada
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source_archive Springer Online Journal Archives 1860-2000
timestamp 2024-05-06T09:48:23.277Z
titel Genetic Determinants of Pseudomonas aeruginosa Colonization in Cystic Fibrosis Patients in Canada
titel_suche Genetic Determinants of Pseudomonas aeruginosa Colonization in Cystic Fibrosis Patients in Canada
topic WW-YZ
uid nat_lic_papers_NLM206291418