Evidence for allelic association of the dopamine β-hydroxylase gene (DBH) with susceptibility to typical migraine
Lea, R. A. ; Dohy, A. ; Jordan, K. ; Quinlan, S. ; Brimage, P. J. ; Griffiths, L. R.
Springer
Published 2000
Springer
Published 2000
| ISSN: |
1364-6753
|
|---|---|
| Keywords: |
Key words Migraine ; DBH ; SERT ; DRD2 ; Linkage
|
| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Medicine
|
| Notes: |
ABSTRACT Migraine is a debilitating neurological disorder characterized by recurrent attacks of severe headache. The disorder is highly prevalent, affecting approximately 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the type and number of genes involved is not yet clear. However, the calcium channel gene, CACNA1A , on chromosome 19 contains mutations responsible for familial hemiplegic migraine, a rare and severe subtype of migraine. There is also evidence to suggest that serotonin- and dopamine-related genes may be involved in the pathogenesis of migraine. This study employed a linkage and association approach to investigate neurotransmitter-related migraine candidate genes. Polymorphisms within the dopamine beta-hydroxylase ( DBH ) gene, serotonin transporter gene ( SERT ), and dopamine receptor gene ( DRD2 ) were tested in 177 unrelated Caucasian migraineurs and 182 control individuals. In addition, an independent sample of 82 families affected with migraine was examined. Unrelated case-control association analysis of a DBH intragenic dinucleotide polymorphism indicated altered allelic distribution between migraine and control groups (χ 2 =16.53, P =0.019). Furthermore, the transmission/disequilibrium test, which was implemented on the family data, also indicated distortion of allele transmission for the same DBH marker (χ 2 =4.44, P =0.035). Together, these results provide evidence for allelic association of the DBH gene with typical migraine susceptibility (Fisher's combined P value=0.006) and indicate that further research into the role of the DBH gene in the etiology of migraine is warranted.
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| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798295298643066882 |
|---|---|
| autor | Lea, R. A. Dohy, A. Jordan, K. Quinlan, S. Brimage, P. J. Griffiths, L. R. |
| autorsonst | Lea, R. A. Dohy, A. Jordan, K. Quinlan, S. Brimage, P. J. Griffiths, L. R. |
| book_url | http://dx.doi.org/ |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM206201222 |
| issn | 1364-6753 |
| journal_name | Neurogenetics |
| materialart | 1 |
| notes | ABSTRACT Migraine is a debilitating neurological disorder characterized by recurrent attacks of severe headache. The disorder is highly prevalent, affecting approximately 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the type and number of genes involved is not yet clear. However, the calcium channel gene, CACNA1A , on chromosome 19 contains mutations responsible for familial hemiplegic migraine, a rare and severe subtype of migraine. There is also evidence to suggest that serotonin- and dopamine-related genes may be involved in the pathogenesis of migraine. This study employed a linkage and association approach to investigate neurotransmitter-related migraine candidate genes. Polymorphisms within the dopamine beta-hydroxylase ( DBH ) gene, serotonin transporter gene ( SERT ), and dopamine receptor gene ( DRD2 ) were tested in 177 unrelated Caucasian migraineurs and 182 control individuals. In addition, an independent sample of 82 families affected with migraine was examined. Unrelated case-control association analysis of a DBH intragenic dinucleotide polymorphism indicated altered allelic distribution between migraine and control groups (χ 2 =16.53, P =0.019). Furthermore, the transmission/disequilibrium test, which was implemented on the family data, also indicated distortion of allele transmission for the same DBH marker (χ 2 =4.44, P =0.035). Together, these results provide evidence for allelic association of the DBH gene with typical migraine susceptibility (Fisher's combined P value=0.006) and indicate that further research into the role of the DBH gene in the etiology of migraine is warranted. |
| package_name | Springer |
| publikationsjahr_anzeige | 2000 |
| publikationsjahr_facette | 2000 |
| publikationsjahr_intervall | 7999:2000-2004 |
| publikationsjahr_sort | 2000 |
| publisher | Springer |
| reference | 3 (2000), S. 35-40 |
| schlagwort | Key words Migraine DBH SERT DRD2 Linkage |
| search_space | articles |
| shingle_author_1 | Lea, R. A. Dohy, A. Jordan, K. Quinlan, S. Brimage, P. J. Griffiths, L. R. |
| shingle_author_2 | Lea, R. A. Dohy, A. Jordan, K. Quinlan, S. Brimage, P. J. Griffiths, L. R. |
| shingle_author_3 | Lea, R. A. Dohy, A. Jordan, K. Quinlan, S. Brimage, P. J. Griffiths, L. R. |
| shingle_author_4 | Lea, R. A. Dohy, A. Jordan, K. Quinlan, S. Brimage, P. J. Griffiths, L. R. |
| shingle_catch_all_1 | Lea, R. A. Dohy, A. Jordan, K. Quinlan, S. Brimage, P. J. Griffiths, L. R. Evidence for allelic association of the dopamine β-hydroxylase gene (DBH) with susceptibility to typical migraine Key words Migraine DBH SERT DRD2 Linkage Key words Migraine DBH SERT DRD2 Linkage ABSTRACT Migraine is a debilitating neurological disorder characterized by recurrent attacks of severe headache. The disorder is highly prevalent, affecting approximately 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the type and number of genes involved is not yet clear. However, the calcium channel gene, CACNA1A , on chromosome 19 contains mutations responsible for familial hemiplegic migraine, a rare and severe subtype of migraine. There is also evidence to suggest that serotonin- and dopamine-related genes may be involved in the pathogenesis of migraine. This study employed a linkage and association approach to investigate neurotransmitter-related migraine candidate genes. Polymorphisms within the dopamine beta-hydroxylase ( DBH ) gene, serotonin transporter gene ( SERT ), and dopamine receptor gene ( DRD2 ) were tested in 177 unrelated Caucasian migraineurs and 182 control individuals. In addition, an independent sample of 82 families affected with migraine was examined. Unrelated case-control association analysis of a DBH intragenic dinucleotide polymorphism indicated altered allelic distribution between migraine and control groups (χ 2 =16.53, P =0.019). Furthermore, the transmission/disequilibrium test, which was implemented on the family data, also indicated distortion of allele transmission for the same DBH marker (χ 2 =4.44, P =0.035). Together, these results provide evidence for allelic association of the DBH gene with typical migraine susceptibility (Fisher's combined P value=0.006) and indicate that further research into the role of the DBH gene in the etiology of migraine is warranted. 1364-6753 13646753 Springer |
| shingle_catch_all_2 | Lea, R. A. Dohy, A. Jordan, K. Quinlan, S. Brimage, P. J. Griffiths, L. R. Evidence for allelic association of the dopamine β-hydroxylase gene (DBH) with susceptibility to typical migraine Key words Migraine DBH SERT DRD2 Linkage Key words Migraine DBH SERT DRD2 Linkage ABSTRACT Migraine is a debilitating neurological disorder characterized by recurrent attacks of severe headache. The disorder is highly prevalent, affecting approximately 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the type and number of genes involved is not yet clear. However, the calcium channel gene, CACNA1A , on chromosome 19 contains mutations responsible for familial hemiplegic migraine, a rare and severe subtype of migraine. There is also evidence to suggest that serotonin- and dopamine-related genes may be involved in the pathogenesis of migraine. This study employed a linkage and association approach to investigate neurotransmitter-related migraine candidate genes. Polymorphisms within the dopamine beta-hydroxylase ( DBH ) gene, serotonin transporter gene ( SERT ), and dopamine receptor gene ( DRD2 ) were tested in 177 unrelated Caucasian migraineurs and 182 control individuals. In addition, an independent sample of 82 families affected with migraine was examined. Unrelated case-control association analysis of a DBH intragenic dinucleotide polymorphism indicated altered allelic distribution between migraine and control groups (χ 2 =16.53, P =0.019). Furthermore, the transmission/disequilibrium test, which was implemented on the family data, also indicated distortion of allele transmission for the same DBH marker (χ 2 =4.44, P =0.035). Together, these results provide evidence for allelic association of the DBH gene with typical migraine susceptibility (Fisher's combined P value=0.006) and indicate that further research into the role of the DBH gene in the etiology of migraine is warranted. 1364-6753 13646753 Springer |
| shingle_catch_all_3 | Lea, R. A. Dohy, A. Jordan, K. Quinlan, S. Brimage, P. J. Griffiths, L. R. Evidence for allelic association of the dopamine β-hydroxylase gene (DBH) with susceptibility to typical migraine Key words Migraine DBH SERT DRD2 Linkage Key words Migraine DBH SERT DRD2 Linkage ABSTRACT Migraine is a debilitating neurological disorder characterized by recurrent attacks of severe headache. The disorder is highly prevalent, affecting approximately 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the type and number of genes involved is not yet clear. However, the calcium channel gene, CACNA1A , on chromosome 19 contains mutations responsible for familial hemiplegic migraine, a rare and severe subtype of migraine. There is also evidence to suggest that serotonin- and dopamine-related genes may be involved in the pathogenesis of migraine. This study employed a linkage and association approach to investigate neurotransmitter-related migraine candidate genes. Polymorphisms within the dopamine beta-hydroxylase ( DBH ) gene, serotonin transporter gene ( SERT ), and dopamine receptor gene ( DRD2 ) were tested in 177 unrelated Caucasian migraineurs and 182 control individuals. In addition, an independent sample of 82 families affected with migraine was examined. Unrelated case-control association analysis of a DBH intragenic dinucleotide polymorphism indicated altered allelic distribution between migraine and control groups (χ 2 =16.53, P =0.019). Furthermore, the transmission/disequilibrium test, which was implemented on the family data, also indicated distortion of allele transmission for the same DBH marker (χ 2 =4.44, P =0.035). Together, these results provide evidence for allelic association of the DBH gene with typical migraine susceptibility (Fisher's combined P value=0.006) and indicate that further research into the role of the DBH gene in the etiology of migraine is warranted. 1364-6753 13646753 Springer |
| shingle_catch_all_4 | Lea, R. A. Dohy, A. Jordan, K. Quinlan, S. Brimage, P. J. Griffiths, L. R. Evidence for allelic association of the dopamine β-hydroxylase gene (DBH) with susceptibility to typical migraine Key words Migraine DBH SERT DRD2 Linkage Key words Migraine DBH SERT DRD2 Linkage ABSTRACT Migraine is a debilitating neurological disorder characterized by recurrent attacks of severe headache. The disorder is highly prevalent, affecting approximately 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the type and number of genes involved is not yet clear. However, the calcium channel gene, CACNA1A , on chromosome 19 contains mutations responsible for familial hemiplegic migraine, a rare and severe subtype of migraine. There is also evidence to suggest that serotonin- and dopamine-related genes may be involved in the pathogenesis of migraine. This study employed a linkage and association approach to investigate neurotransmitter-related migraine candidate genes. Polymorphisms within the dopamine beta-hydroxylase ( DBH ) gene, serotonin transporter gene ( SERT ), and dopamine receptor gene ( DRD2 ) were tested in 177 unrelated Caucasian migraineurs and 182 control individuals. In addition, an independent sample of 82 families affected with migraine was examined. Unrelated case-control association analysis of a DBH intragenic dinucleotide polymorphism indicated altered allelic distribution between migraine and control groups (χ 2 =16.53, P =0.019). Furthermore, the transmission/disequilibrium test, which was implemented on the family data, also indicated distortion of allele transmission for the same DBH marker (χ 2 =4.44, P =0.035). Together, these results provide evidence for allelic association of the DBH gene with typical migraine susceptibility (Fisher's combined P value=0.006) and indicate that further research into the role of the DBH gene in the etiology of migraine is warranted. 1364-6753 13646753 Springer |
| shingle_title_1 | Evidence for allelic association of the dopamine β-hydroxylase gene (DBH) with susceptibility to typical migraine |
| shingle_title_2 | Evidence for allelic association of the dopamine β-hydroxylase gene (DBH) with susceptibility to typical migraine |
| shingle_title_3 | Evidence for allelic association of the dopamine β-hydroxylase gene (DBH) with susceptibility to typical migraine |
| shingle_title_4 | Evidence for allelic association of the dopamine β-hydroxylase gene (DBH) with susceptibility to typical migraine |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:33:58.595Z |
| titel | Evidence for allelic association of the dopamine β-hydroxylase gene (DBH) with susceptibility to typical migraine |
| titel_suche | Evidence for allelic association of the dopamine β-hydroxylase gene (DBH) with susceptibility to typical migraine |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM206201222 |