HLA antigens in Italian type 1 diabetic patients: role of DR3/DR4 antigens and breast feeding in the onset of the disease
Bognetti, E. ; Meschi, F. ; Malavasi, C. ; Pastore, M. R. ; Sergi, A. ; Illeni, M. T. ; Maffeis, C. ; Pinelli, L. ; Chiumello, G.
Springer
Published 1992
Springer
Published 1992
| ISSN: |
1432-5233
|
|---|---|
| Keywords: |
HLA ; Insulin-dependent diabetes mellitus ; Breast feeding ; Childhood
|
| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Medicine
|
| Notes: |
Abstract HLA-A, B, C, DR and DQ typing was performed in 381 Italian insulin-dependent diabetic patients and in 905 normal Italian subjects. The diabetic patients had significantly higher frequencies of HLA-Cw7, B8, B18, DR3, DR4, DQw2 and DQw3 and significantly lower frequencies of HLA-B17, Bw51, DR2, DR7 and DRw11. The frequency of heterozygosity for HLA-DR3/DR4 was significantly higher in patients who developed the disease in the first 2 years of life and DR3+/DR4-, DQw2 and DQw3 alleles were higher in those aged less than 14 years at onset. The HLA-DR4 allele was associated with onset of diabetes in autumn and HLA-B18 with onset in Autumn-winter. Diabetic children who were breast fed had a later onset of insulin-dependent diabetes mellitus than those who were bottle fed but these differences were independent of HLA typing (11.18±0.72 years vs 9.23±0.42 years; mean±SEM). We conclude that: (1) in general, HLA distribution in Italian insulin-dependent diabetic patients reflects previous data reported in other European and North American populations; (2) HLA-DR3 and DR4 are strongly associated with insulin-dependent diabetes in Italy as well, and these alleles seem to predispose to an earlier onset of the disease; and (3) breast feeding may delay the onset of the disease.
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798296009113075712 |
|---|---|
| autor | Bognetti, E. Meschi, F. Malavasi, C. Pastore, M. R. Sergi, A. Illeni, M. T. Maffeis, C. Pinelli, L. Chiumello, G. |
| autorsonst | Bognetti, E. Meschi, F. Malavasi, C. Pastore, M. R. Sergi, A. Illeni, M. T. Maffeis, C. Pinelli, L. Chiumello, G. |
| book_url | http://dx.doi.org/10.1007/BF00779004 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM206139160 |
| issn | 1432-5233 |
| journal_name | Acta diabetologica |
| materialart | 1 |
| notes | Abstract HLA-A, B, C, DR and DQ typing was performed in 381 Italian insulin-dependent diabetic patients and in 905 normal Italian subjects. The diabetic patients had significantly higher frequencies of HLA-Cw7, B8, B18, DR3, DR4, DQw2 and DQw3 and significantly lower frequencies of HLA-B17, Bw51, DR2, DR7 and DRw11. The frequency of heterozygosity for HLA-DR3/DR4 was significantly higher in patients who developed the disease in the first 2 years of life and DR3+/DR4-, DQw2 and DQw3 alleles were higher in those aged less than 14 years at onset. The HLA-DR4 allele was associated with onset of diabetes in autumn and HLA-B18 with onset in Autumn-winter. Diabetic children who were breast fed had a later onset of insulin-dependent diabetes mellitus than those who were bottle fed but these differences were independent of HLA typing (11.18±0.72 years vs 9.23±0.42 years; mean±SEM). We conclude that: (1) in general, HLA distribution in Italian insulin-dependent diabetic patients reflects previous data reported in other European and North American populations; (2) HLA-DR3 and DR4 are strongly associated with insulin-dependent diabetes in Italy as well, and these alleles seem to predispose to an earlier onset of the disease; and (3) breast feeding may delay the onset of the disease. |
| package_name | Springer |
| publikationsjahr_anzeige | 1992 |
| publikationsjahr_facette | 1992 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1992 |
| publisher | Springer |
| reference | 28 (1992), S. 229-232 |
| schlagwort | HLA Insulin-dependent diabetes mellitus Breast feeding Childhood |
| search_space | articles |
| shingle_author_1 | Bognetti, E. Meschi, F. Malavasi, C. Pastore, M. R. Sergi, A. Illeni, M. T. Maffeis, C. Pinelli, L. Chiumello, G. |
| shingle_author_2 | Bognetti, E. Meschi, F. Malavasi, C. Pastore, M. R. Sergi, A. Illeni, M. T. Maffeis, C. Pinelli, L. Chiumello, G. |
| shingle_author_3 | Bognetti, E. Meschi, F. Malavasi, C. Pastore, M. R. Sergi, A. Illeni, M. T. Maffeis, C. Pinelli, L. Chiumello, G. |
| shingle_author_4 | Bognetti, E. Meschi, F. Malavasi, C. Pastore, M. R. Sergi, A. Illeni, M. T. Maffeis, C. Pinelli, L. Chiumello, G. |
| shingle_catch_all_1 | Bognetti, E. Meschi, F. Malavasi, C. Pastore, M. R. Sergi, A. Illeni, M. T. Maffeis, C. Pinelli, L. Chiumello, G. HLA antigens in Italian type 1 diabetic patients: role of DR3/DR4 antigens and breast feeding in the onset of the disease HLA Insulin-dependent diabetes mellitus Breast feeding Childhood HLA Insulin-dependent diabetes mellitus Breast feeding Childhood Abstract HLA-A, B, C, DR and DQ typing was performed in 381 Italian insulin-dependent diabetic patients and in 905 normal Italian subjects. The diabetic patients had significantly higher frequencies of HLA-Cw7, B8, B18, DR3, DR4, DQw2 and DQw3 and significantly lower frequencies of HLA-B17, Bw51, DR2, DR7 and DRw11. The frequency of heterozygosity for HLA-DR3/DR4 was significantly higher in patients who developed the disease in the first 2 years of life and DR3+/DR4-, DQw2 and DQw3 alleles were higher in those aged less than 14 years at onset. The HLA-DR4 allele was associated with onset of diabetes in autumn and HLA-B18 with onset in Autumn-winter. Diabetic children who were breast fed had a later onset of insulin-dependent diabetes mellitus than those who were bottle fed but these differences were independent of HLA typing (11.18±0.72 years vs 9.23±0.42 years; mean±SEM). We conclude that: (1) in general, HLA distribution in Italian insulin-dependent diabetic patients reflects previous data reported in other European and North American populations; (2) HLA-DR3 and DR4 are strongly associated with insulin-dependent diabetes in Italy as well, and these alleles seem to predispose to an earlier onset of the disease; and (3) breast feeding may delay the onset of the disease. 1432-5233 14325233 Springer |
| shingle_catch_all_2 | Bognetti, E. Meschi, F. Malavasi, C. Pastore, M. R. Sergi, A. Illeni, M. T. Maffeis, C. Pinelli, L. Chiumello, G. HLA antigens in Italian type 1 diabetic patients: role of DR3/DR4 antigens and breast feeding in the onset of the disease HLA Insulin-dependent diabetes mellitus Breast feeding Childhood HLA Insulin-dependent diabetes mellitus Breast feeding Childhood Abstract HLA-A, B, C, DR and DQ typing was performed in 381 Italian insulin-dependent diabetic patients and in 905 normal Italian subjects. The diabetic patients had significantly higher frequencies of HLA-Cw7, B8, B18, DR3, DR4, DQw2 and DQw3 and significantly lower frequencies of HLA-B17, Bw51, DR2, DR7 and DRw11. The frequency of heterozygosity for HLA-DR3/DR4 was significantly higher in patients who developed the disease in the first 2 years of life and DR3+/DR4-, DQw2 and DQw3 alleles were higher in those aged less than 14 years at onset. The HLA-DR4 allele was associated with onset of diabetes in autumn and HLA-B18 with onset in Autumn-winter. Diabetic children who were breast fed had a later onset of insulin-dependent diabetes mellitus than those who were bottle fed but these differences were independent of HLA typing (11.18±0.72 years vs 9.23±0.42 years; mean±SEM). We conclude that: (1) in general, HLA distribution in Italian insulin-dependent diabetic patients reflects previous data reported in other European and North American populations; (2) HLA-DR3 and DR4 are strongly associated with insulin-dependent diabetes in Italy as well, and these alleles seem to predispose to an earlier onset of the disease; and (3) breast feeding may delay the onset of the disease. 1432-5233 14325233 Springer |
| shingle_catch_all_3 | Bognetti, E. Meschi, F. Malavasi, C. Pastore, M. R. Sergi, A. Illeni, M. T. Maffeis, C. Pinelli, L. Chiumello, G. HLA antigens in Italian type 1 diabetic patients: role of DR3/DR4 antigens and breast feeding in the onset of the disease HLA Insulin-dependent diabetes mellitus Breast feeding Childhood HLA Insulin-dependent diabetes mellitus Breast feeding Childhood Abstract HLA-A, B, C, DR and DQ typing was performed in 381 Italian insulin-dependent diabetic patients and in 905 normal Italian subjects. The diabetic patients had significantly higher frequencies of HLA-Cw7, B8, B18, DR3, DR4, DQw2 and DQw3 and significantly lower frequencies of HLA-B17, Bw51, DR2, DR7 and DRw11. The frequency of heterozygosity for HLA-DR3/DR4 was significantly higher in patients who developed the disease in the first 2 years of life and DR3+/DR4-, DQw2 and DQw3 alleles were higher in those aged less than 14 years at onset. The HLA-DR4 allele was associated with onset of diabetes in autumn and HLA-B18 with onset in Autumn-winter. Diabetic children who were breast fed had a later onset of insulin-dependent diabetes mellitus than those who were bottle fed but these differences were independent of HLA typing (11.18±0.72 years vs 9.23±0.42 years; mean±SEM). We conclude that: (1) in general, HLA distribution in Italian insulin-dependent diabetic patients reflects previous data reported in other European and North American populations; (2) HLA-DR3 and DR4 are strongly associated with insulin-dependent diabetes in Italy as well, and these alleles seem to predispose to an earlier onset of the disease; and (3) breast feeding may delay the onset of the disease. 1432-5233 14325233 Springer |
| shingle_catch_all_4 | Bognetti, E. Meschi, F. Malavasi, C. Pastore, M. R. Sergi, A. Illeni, M. T. Maffeis, C. Pinelli, L. Chiumello, G. HLA antigens in Italian type 1 diabetic patients: role of DR3/DR4 antigens and breast feeding in the onset of the disease HLA Insulin-dependent diabetes mellitus Breast feeding Childhood HLA Insulin-dependent diabetes mellitus Breast feeding Childhood Abstract HLA-A, B, C, DR and DQ typing was performed in 381 Italian insulin-dependent diabetic patients and in 905 normal Italian subjects. The diabetic patients had significantly higher frequencies of HLA-Cw7, B8, B18, DR3, DR4, DQw2 and DQw3 and significantly lower frequencies of HLA-B17, Bw51, DR2, DR7 and DRw11. The frequency of heterozygosity for HLA-DR3/DR4 was significantly higher in patients who developed the disease in the first 2 years of life and DR3+/DR4-, DQw2 and DQw3 alleles were higher in those aged less than 14 years at onset. The HLA-DR4 allele was associated with onset of diabetes in autumn and HLA-B18 with onset in Autumn-winter. Diabetic children who were breast fed had a later onset of insulin-dependent diabetes mellitus than those who were bottle fed but these differences were independent of HLA typing (11.18±0.72 years vs 9.23±0.42 years; mean±SEM). We conclude that: (1) in general, HLA distribution in Italian insulin-dependent diabetic patients reflects previous data reported in other European and North American populations; (2) HLA-DR3 and DR4 are strongly associated with insulin-dependent diabetes in Italy as well, and these alleles seem to predispose to an earlier onset of the disease; and (3) breast feeding may delay the onset of the disease. 1432-5233 14325233 Springer |
| shingle_title_1 | HLA antigens in Italian type 1 diabetic patients: role of DR3/DR4 antigens and breast feeding in the onset of the disease |
| shingle_title_2 | HLA antigens in Italian type 1 diabetic patients: role of DR3/DR4 antigens and breast feeding in the onset of the disease |
| shingle_title_3 | HLA antigens in Italian type 1 diabetic patients: role of DR3/DR4 antigens and breast feeding in the onset of the disease |
| shingle_title_4 | HLA antigens in Italian type 1 diabetic patients: role of DR3/DR4 antigens and breast feeding in the onset of the disease |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:45:16.836Z |
| titel | HLA antigens in Italian type 1 diabetic patients: role of DR3/DR4 antigens and breast feeding in the onset of the disease |
| titel_suche | HLA antigens in Italian type 1 diabetic patients: role of DR3/DR4 antigens and breast feeding in the onset of the disease |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM206139160 |