Distribution of ADH2 and ALDH2 genotypes in different populations
Goedde, H. W. ; Agarwal, D. P. ; Fritze, G. ; Meier-Tackmann, D. ; Singh, S. ; Beckmann, G. ; Bhatia, K. ; Chen, L. Z. ; Fang, B. ; Lisker, R. ; Paik, Y. K. ; Rothhammer, F. ; Saha, N. ; Segal, B. ; Srivastava, L. M. ; Czeizel, A.
Springer
Published 1992
Springer
Published 1992
| ISSN: |
1432-1203
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|---|---|
| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Biology
Medicine
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| Notes: |
Summary The distribution of the human liver alcohol dehydrogenase, ADH2, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH 1 2 allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH 2 2 gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH22) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295623631372288 |
|---|---|
| autor | Goedde, H. W. Agarwal, D. P. Fritze, G. Meier-Tackmann, D. Singh, S. Beckmann, G. Bhatia, K. Chen, L. Z. Fang, B. Lisker, R. Paik, Y. K. Rothhammer, F. Saha, N. Segal, B. Srivastava, L. M. Czeizel, A. |
| autorsonst | Goedde, H. W. Agarwal, D. P. Fritze, G. Meier-Tackmann, D. Singh, S. Beckmann, G. Bhatia, K. Chen, L. Z. Fang, B. Lisker, R. Paik, Y. K. Rothhammer, F. Saha, N. Segal, B. Srivastava, L. M. Czeizel, A. |
| book_url | http://dx.doi.org/10.1007/BF00197271 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM205632033 |
| issn | 1432-1203 |
| journal_name | Human genetics 〈Berlin〉 |
| materialart | 1 |
| notes | Summary The distribution of the human liver alcohol dehydrogenase, ADH2, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH 1 2 allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH 2 2 gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH22) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease. |
| package_name | Springer |
| publikationsjahr_anzeige | 1992 |
| publikationsjahr_facette | 1992 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1992 |
| publisher | Springer |
| reference | 88 (1992), S. 344-346 |
| search_space | articles |
| shingle_author_1 | Goedde, H. W. Agarwal, D. P. Fritze, G. Meier-Tackmann, D. Singh, S. Beckmann, G. Bhatia, K. Chen, L. Z. Fang, B. Lisker, R. Paik, Y. K. Rothhammer, F. Saha, N. Segal, B. Srivastava, L. M. Czeizel, A. |
| shingle_author_2 | Goedde, H. W. Agarwal, D. P. Fritze, G. Meier-Tackmann, D. Singh, S. Beckmann, G. Bhatia, K. Chen, L. Z. Fang, B. Lisker, R. Paik, Y. K. Rothhammer, F. Saha, N. Segal, B. Srivastava, L. M. Czeizel, A. |
| shingle_author_3 | Goedde, H. W. Agarwal, D. P. Fritze, G. Meier-Tackmann, D. Singh, S. Beckmann, G. Bhatia, K. Chen, L. Z. Fang, B. Lisker, R. Paik, Y. K. Rothhammer, F. Saha, N. Segal, B. Srivastava, L. M. Czeizel, A. |
| shingle_author_4 | Goedde, H. W. Agarwal, D. P. Fritze, G. Meier-Tackmann, D. Singh, S. Beckmann, G. Bhatia, K. Chen, L. Z. Fang, B. Lisker, R. Paik, Y. K. Rothhammer, F. Saha, N. Segal, B. Srivastava, L. M. Czeizel, A. |
| shingle_catch_all_1 | Goedde, H. W. Agarwal, D. P. Fritze, G. Meier-Tackmann, D. Singh, S. Beckmann, G. Bhatia, K. Chen, L. Z. Fang, B. Lisker, R. Paik, Y. K. Rothhammer, F. Saha, N. Segal, B. Srivastava, L. M. Czeizel, A. Distribution of ADH2 and ALDH2 genotypes in different populations Summary The distribution of the human liver alcohol dehydrogenase, ADH2, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH 1 2 allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH 2 2 gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH22) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease. 1432-1203 14321203 Springer |
| shingle_catch_all_2 | Goedde, H. W. Agarwal, D. P. Fritze, G. Meier-Tackmann, D. Singh, S. Beckmann, G. Bhatia, K. Chen, L. Z. Fang, B. Lisker, R. Paik, Y. K. Rothhammer, F. Saha, N. Segal, B. Srivastava, L. M. Czeizel, A. Distribution of ADH2 and ALDH2 genotypes in different populations Summary The distribution of the human liver alcohol dehydrogenase, ADH2, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH 1 2 allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH 2 2 gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH22) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease. 1432-1203 14321203 Springer |
| shingle_catch_all_3 | Goedde, H. W. Agarwal, D. P. Fritze, G. Meier-Tackmann, D. Singh, S. Beckmann, G. Bhatia, K. Chen, L. Z. Fang, B. Lisker, R. Paik, Y. K. Rothhammer, F. Saha, N. Segal, B. Srivastava, L. M. Czeizel, A. Distribution of ADH2 and ALDH2 genotypes in different populations Summary The distribution of the human liver alcohol dehydrogenase, ADH2, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH 1 2 allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH 2 2 gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH22) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease. 1432-1203 14321203 Springer |
| shingle_catch_all_4 | Goedde, H. W. Agarwal, D. P. Fritze, G. Meier-Tackmann, D. Singh, S. Beckmann, G. Bhatia, K. Chen, L. Z. Fang, B. Lisker, R. Paik, Y. K. Rothhammer, F. Saha, N. Segal, B. Srivastava, L. M. Czeizel, A. Distribution of ADH2 and ALDH2 genotypes in different populations Summary The distribution of the human liver alcohol dehydrogenase, ADH2, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH 1 2 allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH 2 2 gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH22) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease. 1432-1203 14321203 Springer |
| shingle_title_1 | Distribution of ADH2 and ALDH2 genotypes in different populations |
| shingle_title_2 | Distribution of ADH2 and ALDH2 genotypes in different populations |
| shingle_title_3 | Distribution of ADH2 and ALDH2 genotypes in different populations |
| shingle_title_4 | Distribution of ADH2 and ALDH2 genotypes in different populations |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:39:09.522Z |
| titel | Distribution of ADH2 and ALDH2 genotypes in different populations |
| titel_suche | Distribution of ADH2 and ALDH2 genotypes in different populations |
| topic | W WW-YZ |
| uid | nat_lic_papers_NLM205632033 |