New distal marker closely linked to the fragile X locus
Hulsebos, T. J. M. ; Oostra, B. A. ; Broersen, S. ; Smits, A. ; Oost, B. A. ; Westerveld, A.
Springer
Published 1991
Springer
Published 1991
| ISSN: |
1432-1203
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|---|---|
| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Biology
Medicine
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| Notes: |
Summary We have isolated II-10, a new X-chromosomal probe that identifies a highly informative two-allele TaqI restriction fragment length polymorphism at locus DXS466. Using somatic cell hybrids containing distinct portions of the long arm of the X chromosome, we could localize DXS466 between DXS296 and DXS304, both of which are closely linked distal markers for fragile X. This regional localization was supported by the analysis, in fragile X families, of recombination events between these three loci, the fragile X locus and locus DXS52, the latter being located at a more distal position. DXS466 is closely linked to the fragile X locus with a peak lod score of 7.79 at a recombination fraction of 0.02. Heterozygosity of DXS466 is approximately 50%. Its close proximity and relatively high informativity make DXS466 a valuable new diagnostic DNA marker for fragile X.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295622952943616 |
|---|---|
| autor | Hulsebos, T. J. M. Oostra, B. A. Broersen, S. Smits, A. Oost, B. A. Westerveld, A. |
| autorsonst | Hulsebos, T. J. M. Oostra, B. A. Broersen, S. Smits, A. Oost, B. A. Westerveld, A. |
| book_url | http://dx.doi.org/10.1007/BF00200922 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM205630464 |
| issn | 1432-1203 |
| journal_name | Human genetics 〈Berlin〉 |
| materialart | 1 |
| notes | Summary We have isolated II-10, a new X-chromosomal probe that identifies a highly informative two-allele TaqI restriction fragment length polymorphism at locus DXS466. Using somatic cell hybrids containing distinct portions of the long arm of the X chromosome, we could localize DXS466 between DXS296 and DXS304, both of which are closely linked distal markers for fragile X. This regional localization was supported by the analysis, in fragile X families, of recombination events between these three loci, the fragile X locus and locus DXS52, the latter being located at a more distal position. DXS466 is closely linked to the fragile X locus with a peak lod score of 7.79 at a recombination fraction of 0.02. Heterozygosity of DXS466 is approximately 50%. Its close proximity and relatively high informativity make DXS466 a valuable new diagnostic DNA marker for fragile X. |
| package_name | Springer |
| publikationsjahr_anzeige | 1991 |
| publikationsjahr_facette | 1991 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1991 |
| publisher | Springer |
| reference | 87 (1991), S. 369-372 |
| search_space | articles |
| shingle_author_1 | Hulsebos, T. J. M. Oostra, B. A. Broersen, S. Smits, A. Oost, B. A. Westerveld, A. |
| shingle_author_2 | Hulsebos, T. J. M. Oostra, B. A. Broersen, S. Smits, A. Oost, B. A. Westerveld, A. |
| shingle_author_3 | Hulsebos, T. J. M. Oostra, B. A. Broersen, S. Smits, A. Oost, B. A. Westerveld, A. |
| shingle_author_4 | Hulsebos, T. J. M. Oostra, B. A. Broersen, S. Smits, A. Oost, B. A. Westerveld, A. |
| shingle_catch_all_1 | Hulsebos, T. J. M. Oostra, B. A. Broersen, S. Smits, A. Oost, B. A. Westerveld, A. New distal marker closely linked to the fragile X locus Summary We have isolated II-10, a new X-chromosomal probe that identifies a highly informative two-allele TaqI restriction fragment length polymorphism at locus DXS466. Using somatic cell hybrids containing distinct portions of the long arm of the X chromosome, we could localize DXS466 between DXS296 and DXS304, both of which are closely linked distal markers for fragile X. This regional localization was supported by the analysis, in fragile X families, of recombination events between these three loci, the fragile X locus and locus DXS52, the latter being located at a more distal position. DXS466 is closely linked to the fragile X locus with a peak lod score of 7.79 at a recombination fraction of 0.02. Heterozygosity of DXS466 is approximately 50%. Its close proximity and relatively high informativity make DXS466 a valuable new diagnostic DNA marker for fragile X. 1432-1203 14321203 Springer |
| shingle_catch_all_2 | Hulsebos, T. J. M. Oostra, B. A. Broersen, S. Smits, A. Oost, B. A. Westerveld, A. New distal marker closely linked to the fragile X locus Summary We have isolated II-10, a new X-chromosomal probe that identifies a highly informative two-allele TaqI restriction fragment length polymorphism at locus DXS466. Using somatic cell hybrids containing distinct portions of the long arm of the X chromosome, we could localize DXS466 between DXS296 and DXS304, both of which are closely linked distal markers for fragile X. This regional localization was supported by the analysis, in fragile X families, of recombination events between these three loci, the fragile X locus and locus DXS52, the latter being located at a more distal position. DXS466 is closely linked to the fragile X locus with a peak lod score of 7.79 at a recombination fraction of 0.02. Heterozygosity of DXS466 is approximately 50%. Its close proximity and relatively high informativity make DXS466 a valuable new diagnostic DNA marker for fragile X. 1432-1203 14321203 Springer |
| shingle_catch_all_3 | Hulsebos, T. J. M. Oostra, B. A. Broersen, S. Smits, A. Oost, B. A. Westerveld, A. New distal marker closely linked to the fragile X locus Summary We have isolated II-10, a new X-chromosomal probe that identifies a highly informative two-allele TaqI restriction fragment length polymorphism at locus DXS466. Using somatic cell hybrids containing distinct portions of the long arm of the X chromosome, we could localize DXS466 between DXS296 and DXS304, both of which are closely linked distal markers for fragile X. This regional localization was supported by the analysis, in fragile X families, of recombination events between these three loci, the fragile X locus and locus DXS52, the latter being located at a more distal position. DXS466 is closely linked to the fragile X locus with a peak lod score of 7.79 at a recombination fraction of 0.02. Heterozygosity of DXS466 is approximately 50%. Its close proximity and relatively high informativity make DXS466 a valuable new diagnostic DNA marker for fragile X. 1432-1203 14321203 Springer |
| shingle_catch_all_4 | Hulsebos, T. J. M. Oostra, B. A. Broersen, S. Smits, A. Oost, B. A. Westerveld, A. New distal marker closely linked to the fragile X locus Summary We have isolated II-10, a new X-chromosomal probe that identifies a highly informative two-allele TaqI restriction fragment length polymorphism at locus DXS466. Using somatic cell hybrids containing distinct portions of the long arm of the X chromosome, we could localize DXS466 between DXS296 and DXS304, both of which are closely linked distal markers for fragile X. This regional localization was supported by the analysis, in fragile X families, of recombination events between these three loci, the fragile X locus and locus DXS52, the latter being located at a more distal position. DXS466 is closely linked to the fragile X locus with a peak lod score of 7.79 at a recombination fraction of 0.02. Heterozygosity of DXS466 is approximately 50%. Its close proximity and relatively high informativity make DXS466 a valuable new diagnostic DNA marker for fragile X. 1432-1203 14321203 Springer |
| shingle_title_1 | New distal marker closely linked to the fragile X locus |
| shingle_title_2 | New distal marker closely linked to the fragile X locus |
| shingle_title_3 | New distal marker closely linked to the fragile X locus |
| shingle_title_4 | New distal marker closely linked to the fragile X locus |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:39:07.990Z |
| titel | New distal marker closely linked to the fragile X locus |
| titel_suche | New distal marker closely linked to the fragile X locus |
| topic | W WW-YZ |
| uid | nat_lic_papers_NLM205630464 |