α°- and β°- Thalassemia in a Thai family: unusually mild homozygous β°-thalassemia without α-globin gene deletion
| ISSN: |
1432-1203
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Biology
Medicine
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| Notes: |
Summary Alpha-globin genes were analyzed by the direct method of DNA mapping using α- and ζ-globin specific probes in a Thai family in which the proposita was an unusually mild β°-thalessemia homozygote. α°-Thalessemia was found to be segregating in the family, inherited from the proposita's father by one of her younger sisters. However, α°-thatlessemia was not detected by this DNA mapping in the proposita. The mild homozygous β°-thalessemia in this family may result from interactions of a non-deletion α-thalassemia, a gene responsible for high proteolytic activity permitting more balanced globin-chain levels, or from an unusually active hemoglobin F production in the proposita.
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| Type of Medium: |
Electronic Resource
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| URL: |