The cincinnati lipid research clinic family study: Familial determinants of plasma uric acid
Rao, D. C. ; Laskarzewski, P. M. ; Morrison, J. A. ; Khoury, P. ; Kelly, K. ; Glueck, C. J.
Springer
Published 1982
Springer
Published 1982
| ISSN: |
1432-1203
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Biology
Medicine
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| Notes: |
Summary Commingling analysis of plasma uric acid levels in a random sample of 160 nuclear families supports the hypothesis that there is a mixture of three distributions. Assuming one, two, and three components in the underlying distribution, we obtained the corresponding p-values (for power transformation) as 0.059, 1.040, and 1.643, respectively. Path analysis with p=0.059 gives genetic (h 2) and cultural (c 2) heritabilities as 0.256 and 0.199, without much support for intergenerational differences, assortative mating, or maternal effects. Complex segregation analysis with p=0.059 supports multifactorial inheritance, consistent with the findings of Gulbrandsen et al. (1979) and Morton (1979) in other populations. This study also fails to support a major locus hypothesis, contrary to earlier reports.
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| Type of Medium: |
Electronic Resource
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| URL: |