Polymorphism of the HLA class II loci in Siberian populations
Grahovac, Blazenka ; Sukernik, R. I. ; O’hUigin, C. ; Zaleska-Rutczynska, Zofia ; Blagitko, Nadezhda ; Raldugina, Olga ; Kosutic, Tanja ; Satta, Yoko ; Figueroa, Felipe ; Takahata, Naoyuki ; Klein, Jan
Springer
Published 1998
Springer
Published 1998
| ISSN: |
1432-1203
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|---|---|
| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Biology
Medicine
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| Notes: |
Abstract The populations that colonized Siberia diverged from one another in the Paleolithic and evolved in isolation until today. These populations are therefore a rich source of information about the conditions under which the initial divergence of modern humans occurred. In the present study we used the HLA system, first, to investigate the evolution of the human major histocompatibility complex (MHC) itself, and second, to reveal the relationships among Siberian populations. We determined allelic frequencies at five HLA class II loci (DRB1, DQA1, DQB1, DPA1, and DPB1) in seven Siberian populations (Ket, Evenk, Koryak, Chukchi, Nivkh, Udege, and Siberian Eskimo) by the combination of single-stranded conformational polymorphism and DNA sequencing analysis. We then used the gene frequency data to deduce the HLA class II haplotypes and their frequencies. Despite high polymorphism at four of the five loci, no new alleles could be detected. This finding is consistent with a conserved evolution of human class II MHC genes. We found a high number of HLA class II haplotypes in Siberian populations. More haplotypes have been found in Siberia than in any other population. Some of the haplotypes are shared with non-Siberian populations, but most of them are new, and some represent “forbidden” combinations of DQA1 and DQB1 alleles. We suggest that a set of “public” haplotypes was brought to Siberia with the colonizers but that most of the new haplotypes were generated in Siberia by recombination and are part of a haplotype pool that is turning over rapidly. The allelic frequencies at the DRB1 locus divide the Siberian populations into eastern and central Siberian branches; only the former shows a clear genealogical relationship to Amerinds.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295614774050816 |
|---|---|
| autor | Grahovac, Blazenka Sukernik, R. I. O’hUigin, C. Zaleska-Rutczynska, Zofia Blagitko, Nadezhda Raldugina, Olga Kosutic, Tanja Satta, Yoko Figueroa, Felipe Takahata, Naoyuki Klein, Jan |
| autorsonst | Grahovac, Blazenka Sukernik, R. I. O’hUigin, C. Zaleska-Rutczynska, Zofia Blagitko, Nadezhda Raldugina, Olga Kosutic, Tanja Satta, Yoko Figueroa, Felipe Takahata, Naoyuki Klein, Jan |
| book_url | http://dx.doi.org/10.1007/s004390050650 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM20556691X |
| issn | 1432-1203 |
| journal_name | Human genetics 〈Berlin〉 |
| materialart | 1 |
| notes | Abstract The populations that colonized Siberia diverged from one another in the Paleolithic and evolved in isolation until today. These populations are therefore a rich source of information about the conditions under which the initial divergence of modern humans occurred. In the present study we used the HLA system, first, to investigate the evolution of the human major histocompatibility complex (MHC) itself, and second, to reveal the relationships among Siberian populations. We determined allelic frequencies at five HLA class II loci (DRB1, DQA1, DQB1, DPA1, and DPB1) in seven Siberian populations (Ket, Evenk, Koryak, Chukchi, Nivkh, Udege, and Siberian Eskimo) by the combination of single-stranded conformational polymorphism and DNA sequencing analysis. We then used the gene frequency data to deduce the HLA class II haplotypes and their frequencies. Despite high polymorphism at four of the five loci, no new alleles could be detected. This finding is consistent with a conserved evolution of human class II MHC genes. We found a high number of HLA class II haplotypes in Siberian populations. More haplotypes have been found in Siberia than in any other population. Some of the haplotypes are shared with non-Siberian populations, but most of them are new, and some represent “forbidden” combinations of DQA1 and DQB1 alleles. We suggest that a set of “public” haplotypes was brought to Siberia with the colonizers but that most of the new haplotypes were generated in Siberia by recombination and are part of a haplotype pool that is turning over rapidly. The allelic frequencies at the DRB1 locus divide the Siberian populations into eastern and central Siberian branches; only the former shows a clear genealogical relationship to Amerinds. |
| package_name | Springer |
| publikationsjahr_anzeige | 1998 |
| publikationsjahr_facette | 1998 |
| publikationsjahr_intervall | 8004:1995-1999 |
| publikationsjahr_sort | 1998 |
| publisher | Springer |
| reference | 102 (1998), S. 27-43 |
| search_space | articles |
| shingle_author_1 | Grahovac, Blazenka Sukernik, R. I. O’hUigin, C. Zaleska-Rutczynska, Zofia Blagitko, Nadezhda Raldugina, Olga Kosutic, Tanja Satta, Yoko Figueroa, Felipe Takahata, Naoyuki Klein, Jan |
| shingle_author_2 | Grahovac, Blazenka Sukernik, R. I. O’hUigin, C. Zaleska-Rutczynska, Zofia Blagitko, Nadezhda Raldugina, Olga Kosutic, Tanja Satta, Yoko Figueroa, Felipe Takahata, Naoyuki Klein, Jan |
| shingle_author_3 | Grahovac, Blazenka Sukernik, R. I. O’hUigin, C. Zaleska-Rutczynska, Zofia Blagitko, Nadezhda Raldugina, Olga Kosutic, Tanja Satta, Yoko Figueroa, Felipe Takahata, Naoyuki Klein, Jan |
| shingle_author_4 | Grahovac, Blazenka Sukernik, R. I. O’hUigin, C. Zaleska-Rutczynska, Zofia Blagitko, Nadezhda Raldugina, Olga Kosutic, Tanja Satta, Yoko Figueroa, Felipe Takahata, Naoyuki Klein, Jan |
| shingle_catch_all_1 | Grahovac, Blazenka Sukernik, R. I. O’hUigin, C. Zaleska-Rutczynska, Zofia Blagitko, Nadezhda Raldugina, Olga Kosutic, Tanja Satta, Yoko Figueroa, Felipe Takahata, Naoyuki Klein, Jan Polymorphism of the HLA class II loci in Siberian populations Abstract The populations that colonized Siberia diverged from one another in the Paleolithic and evolved in isolation until today. These populations are therefore a rich source of information about the conditions under which the initial divergence of modern humans occurred. In the present study we used the HLA system, first, to investigate the evolution of the human major histocompatibility complex (MHC) itself, and second, to reveal the relationships among Siberian populations. We determined allelic frequencies at five HLA class II loci (DRB1, DQA1, DQB1, DPA1, and DPB1) in seven Siberian populations (Ket, Evenk, Koryak, Chukchi, Nivkh, Udege, and Siberian Eskimo) by the combination of single-stranded conformational polymorphism and DNA sequencing analysis. We then used the gene frequency data to deduce the HLA class II haplotypes and their frequencies. Despite high polymorphism at four of the five loci, no new alleles could be detected. This finding is consistent with a conserved evolution of human class II MHC genes. We found a high number of HLA class II haplotypes in Siberian populations. More haplotypes have been found in Siberia than in any other population. Some of the haplotypes are shared with non-Siberian populations, but most of them are new, and some represent “forbidden” combinations of DQA1 and DQB1 alleles. We suggest that a set of “public” haplotypes was brought to Siberia with the colonizers but that most of the new haplotypes were generated in Siberia by recombination and are part of a haplotype pool that is turning over rapidly. The allelic frequencies at the DRB1 locus divide the Siberian populations into eastern and central Siberian branches; only the former shows a clear genealogical relationship to Amerinds. 1432-1203 14321203 Springer |
| shingle_catch_all_2 | Grahovac, Blazenka Sukernik, R. I. O’hUigin, C. Zaleska-Rutczynska, Zofia Blagitko, Nadezhda Raldugina, Olga Kosutic, Tanja Satta, Yoko Figueroa, Felipe Takahata, Naoyuki Klein, Jan Polymorphism of the HLA class II loci in Siberian populations Abstract The populations that colonized Siberia diverged from one another in the Paleolithic and evolved in isolation until today. These populations are therefore a rich source of information about the conditions under which the initial divergence of modern humans occurred. In the present study we used the HLA system, first, to investigate the evolution of the human major histocompatibility complex (MHC) itself, and second, to reveal the relationships among Siberian populations. We determined allelic frequencies at five HLA class II loci (DRB1, DQA1, DQB1, DPA1, and DPB1) in seven Siberian populations (Ket, Evenk, Koryak, Chukchi, Nivkh, Udege, and Siberian Eskimo) by the combination of single-stranded conformational polymorphism and DNA sequencing analysis. We then used the gene frequency data to deduce the HLA class II haplotypes and their frequencies. Despite high polymorphism at four of the five loci, no new alleles could be detected. This finding is consistent with a conserved evolution of human class II MHC genes. We found a high number of HLA class II haplotypes in Siberian populations. More haplotypes have been found in Siberia than in any other population. Some of the haplotypes are shared with non-Siberian populations, but most of them are new, and some represent “forbidden” combinations of DQA1 and DQB1 alleles. We suggest that a set of “public” haplotypes was brought to Siberia with the colonizers but that most of the new haplotypes were generated in Siberia by recombination and are part of a haplotype pool that is turning over rapidly. The allelic frequencies at the DRB1 locus divide the Siberian populations into eastern and central Siberian branches; only the former shows a clear genealogical relationship to Amerinds. 1432-1203 14321203 Springer |
| shingle_catch_all_3 | Grahovac, Blazenka Sukernik, R. I. O’hUigin, C. Zaleska-Rutczynska, Zofia Blagitko, Nadezhda Raldugina, Olga Kosutic, Tanja Satta, Yoko Figueroa, Felipe Takahata, Naoyuki Klein, Jan Polymorphism of the HLA class II loci in Siberian populations Abstract The populations that colonized Siberia diverged from one another in the Paleolithic and evolved in isolation until today. These populations are therefore a rich source of information about the conditions under which the initial divergence of modern humans occurred. In the present study we used the HLA system, first, to investigate the evolution of the human major histocompatibility complex (MHC) itself, and second, to reveal the relationships among Siberian populations. We determined allelic frequencies at five HLA class II loci (DRB1, DQA1, DQB1, DPA1, and DPB1) in seven Siberian populations (Ket, Evenk, Koryak, Chukchi, Nivkh, Udege, and Siberian Eskimo) by the combination of single-stranded conformational polymorphism and DNA sequencing analysis. We then used the gene frequency data to deduce the HLA class II haplotypes and their frequencies. Despite high polymorphism at four of the five loci, no new alleles could be detected. This finding is consistent with a conserved evolution of human class II MHC genes. We found a high number of HLA class II haplotypes in Siberian populations. More haplotypes have been found in Siberia than in any other population. Some of the haplotypes are shared with non-Siberian populations, but most of them are new, and some represent “forbidden” combinations of DQA1 and DQB1 alleles. We suggest that a set of “public” haplotypes was brought to Siberia with the colonizers but that most of the new haplotypes were generated in Siberia by recombination and are part of a haplotype pool that is turning over rapidly. The allelic frequencies at the DRB1 locus divide the Siberian populations into eastern and central Siberian branches; only the former shows a clear genealogical relationship to Amerinds. 1432-1203 14321203 Springer |
| shingle_catch_all_4 | Grahovac, Blazenka Sukernik, R. I. O’hUigin, C. Zaleska-Rutczynska, Zofia Blagitko, Nadezhda Raldugina, Olga Kosutic, Tanja Satta, Yoko Figueroa, Felipe Takahata, Naoyuki Klein, Jan Polymorphism of the HLA class II loci in Siberian populations Abstract The populations that colonized Siberia diverged from one another in the Paleolithic and evolved in isolation until today. These populations are therefore a rich source of information about the conditions under which the initial divergence of modern humans occurred. In the present study we used the HLA system, first, to investigate the evolution of the human major histocompatibility complex (MHC) itself, and second, to reveal the relationships among Siberian populations. We determined allelic frequencies at five HLA class II loci (DRB1, DQA1, DQB1, DPA1, and DPB1) in seven Siberian populations (Ket, Evenk, Koryak, Chukchi, Nivkh, Udege, and Siberian Eskimo) by the combination of single-stranded conformational polymorphism and DNA sequencing analysis. We then used the gene frequency data to deduce the HLA class II haplotypes and their frequencies. Despite high polymorphism at four of the five loci, no new alleles could be detected. This finding is consistent with a conserved evolution of human class II MHC genes. We found a high number of HLA class II haplotypes in Siberian populations. More haplotypes have been found in Siberia than in any other population. Some of the haplotypes are shared with non-Siberian populations, but most of them are new, and some represent “forbidden” combinations of DQA1 and DQB1 alleles. We suggest that a set of “public” haplotypes was brought to Siberia with the colonizers but that most of the new haplotypes were generated in Siberia by recombination and are part of a haplotype pool that is turning over rapidly. The allelic frequencies at the DRB1 locus divide the Siberian populations into eastern and central Siberian branches; only the former shows a clear genealogical relationship to Amerinds. 1432-1203 14321203 Springer |
| shingle_title_1 | Polymorphism of the HLA class II loci in Siberian populations |
| shingle_title_2 | Polymorphism of the HLA class II loci in Siberian populations |
| shingle_title_3 | Polymorphism of the HLA class II loci in Siberian populations |
| shingle_title_4 | Polymorphism of the HLA class II loci in Siberian populations |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:39:01.072Z |
| titel | Polymorphism of the HLA class II loci in Siberian populations |
| titel_suche | Polymorphism of the HLA class II loci in Siberian populations |
| topic | W WW-YZ |
| uid | nat_lic_papers_NLM20556691X |