Promoter trapping identifies real genes in C. elegans
Hope, I. A. ; Arnold, J. M. ; McCarroll, D. ; Jun, G. ; Krupa, A. P. ; Herbert, R.
Springer
Published 1998
Springer
Published 1998
| ISSN: |
1617-4623
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|---|---|
| Keywords: |
Key wordsCaenorhabditis elegans ; Gene expression patterns ; Genome sequence
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Biology
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| Notes: |
Abstract Promoter trapping involved screening uncharacterized fragments of C. elegans genomic DNA for C. elegans promoter activity. By sequencing the ends of these DNA fragments and locating their genomic origin using the available genome sequence data, promoter trapping has now been shown to identify real promoters of real genes, exactly as anticipated. Developmental expression patterns have thereby been linked to gene sequence, allowing further inferences on gene function to be drawn. Some expression patterns generated by promoter trapping include subcellular details. Localization to the surface of particular cells or even particular aspects of the cell surface was found to be consistent with the genes, now associated with these patterns, encoding membrane-spanning proteins. Data on gene expression patterns are easier to generate and characterize than mutant phenotypes and may provide the best means of interpreting the large quantity of sequence data currently being generated in genome projects.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798297393914970112 |
|---|---|
| autor | Hope, I. A. Arnold, J. M. McCarroll, D. Jun, G. Krupa, A. P. Herbert, R. |
| autorsonst | Hope, I. A. Arnold, J. M. McCarroll, D. Jun, G. Krupa, A. P. Herbert, R. |
| book_url | http://dx.doi.org/10.1007/s004380050899 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM205536956 |
| issn | 1617-4623 |
| journal_name | Molecular genetics and genomics |
| materialart | 1 |
| notes | Abstract Promoter trapping involved screening uncharacterized fragments of C. elegans genomic DNA for C. elegans promoter activity. By sequencing the ends of these DNA fragments and locating their genomic origin using the available genome sequence data, promoter trapping has now been shown to identify real promoters of real genes, exactly as anticipated. Developmental expression patterns have thereby been linked to gene sequence, allowing further inferences on gene function to be drawn. Some expression patterns generated by promoter trapping include subcellular details. Localization to the surface of particular cells or even particular aspects of the cell surface was found to be consistent with the genes, now associated with these patterns, encoding membrane-spanning proteins. Data on gene expression patterns are easier to generate and characterize than mutant phenotypes and may provide the best means of interpreting the large quantity of sequence data currently being generated in genome projects. |
| package_name | Springer |
| publikationsjahr_anzeige | 1998 |
| publikationsjahr_facette | 1998 |
| publikationsjahr_intervall | 8004:1995-1999 |
| publikationsjahr_sort | 1998 |
| publisher | Springer |
| reference | 260 (1998), S. 300-308 |
| schlagwort | Key wordsCaenorhabditis elegans Gene expression patterns Genome sequence |
| search_space | articles |
| shingle_author_1 | Hope, I. A. Arnold, J. M. McCarroll, D. Jun, G. Krupa, A. P. Herbert, R. |
| shingle_author_2 | Hope, I. A. Arnold, J. M. McCarroll, D. Jun, G. Krupa, A. P. Herbert, R. |
| shingle_author_3 | Hope, I. A. Arnold, J. M. McCarroll, D. Jun, G. Krupa, A. P. Herbert, R. |
| shingle_author_4 | Hope, I. A. Arnold, J. M. McCarroll, D. Jun, G. Krupa, A. P. Herbert, R. |
| shingle_catch_all_1 | Hope, I. A. Arnold, J. M. McCarroll, D. Jun, G. Krupa, A. P. Herbert, R. Promoter trapping identifies real genes in C. elegans Key wordsCaenorhabditis elegans Gene expression patterns Genome sequence Key wordsCaenorhabditis elegans Gene expression patterns Genome sequence Abstract Promoter trapping involved screening uncharacterized fragments of C. elegans genomic DNA for C. elegans promoter activity. By sequencing the ends of these DNA fragments and locating their genomic origin using the available genome sequence data, promoter trapping has now been shown to identify real promoters of real genes, exactly as anticipated. Developmental expression patterns have thereby been linked to gene sequence, allowing further inferences on gene function to be drawn. Some expression patterns generated by promoter trapping include subcellular details. Localization to the surface of particular cells or even particular aspects of the cell surface was found to be consistent with the genes, now associated with these patterns, encoding membrane-spanning proteins. Data on gene expression patterns are easier to generate and characterize than mutant phenotypes and may provide the best means of interpreting the large quantity of sequence data currently being generated in genome projects. 1617-4623 16174623 Springer |
| shingle_catch_all_2 | Hope, I. A. Arnold, J. M. McCarroll, D. Jun, G. Krupa, A. P. Herbert, R. Promoter trapping identifies real genes in C. elegans Key wordsCaenorhabditis elegans Gene expression patterns Genome sequence Key wordsCaenorhabditis elegans Gene expression patterns Genome sequence Abstract Promoter trapping involved screening uncharacterized fragments of C. elegans genomic DNA for C. elegans promoter activity. By sequencing the ends of these DNA fragments and locating their genomic origin using the available genome sequence data, promoter trapping has now been shown to identify real promoters of real genes, exactly as anticipated. Developmental expression patterns have thereby been linked to gene sequence, allowing further inferences on gene function to be drawn. Some expression patterns generated by promoter trapping include subcellular details. Localization to the surface of particular cells or even particular aspects of the cell surface was found to be consistent with the genes, now associated with these patterns, encoding membrane-spanning proteins. Data on gene expression patterns are easier to generate and characterize than mutant phenotypes and may provide the best means of interpreting the large quantity of sequence data currently being generated in genome projects. 1617-4623 16174623 Springer |
| shingle_catch_all_3 | Hope, I. A. Arnold, J. M. McCarroll, D. Jun, G. Krupa, A. P. Herbert, R. Promoter trapping identifies real genes in C. elegans Key wordsCaenorhabditis elegans Gene expression patterns Genome sequence Key wordsCaenorhabditis elegans Gene expression patterns Genome sequence Abstract Promoter trapping involved screening uncharacterized fragments of C. elegans genomic DNA for C. elegans promoter activity. By sequencing the ends of these DNA fragments and locating their genomic origin using the available genome sequence data, promoter trapping has now been shown to identify real promoters of real genes, exactly as anticipated. Developmental expression patterns have thereby been linked to gene sequence, allowing further inferences on gene function to be drawn. Some expression patterns generated by promoter trapping include subcellular details. Localization to the surface of particular cells or even particular aspects of the cell surface was found to be consistent with the genes, now associated with these patterns, encoding membrane-spanning proteins. Data on gene expression patterns are easier to generate and characterize than mutant phenotypes and may provide the best means of interpreting the large quantity of sequence data currently being generated in genome projects. 1617-4623 16174623 Springer |
| shingle_catch_all_4 | Hope, I. A. Arnold, J. M. McCarroll, D. Jun, G. Krupa, A. P. Herbert, R. Promoter trapping identifies real genes in C. elegans Key wordsCaenorhabditis elegans Gene expression patterns Genome sequence Key wordsCaenorhabditis elegans Gene expression patterns Genome sequence Abstract Promoter trapping involved screening uncharacterized fragments of C. elegans genomic DNA for C. elegans promoter activity. By sequencing the ends of these DNA fragments and locating their genomic origin using the available genome sequence data, promoter trapping has now been shown to identify real promoters of real genes, exactly as anticipated. Developmental expression patterns have thereby been linked to gene sequence, allowing further inferences on gene function to be drawn. Some expression patterns generated by promoter trapping include subcellular details. Localization to the surface of particular cells or even particular aspects of the cell surface was found to be consistent with the genes, now associated with these patterns, encoding membrane-spanning proteins. Data on gene expression patterns are easier to generate and characterize than mutant phenotypes and may provide the best means of interpreting the large quantity of sequence data currently being generated in genome projects. 1617-4623 16174623 Springer |
| shingle_title_1 | Promoter trapping identifies real genes in C. elegans |
| shingle_title_2 | Promoter trapping identifies real genes in C. elegans |
| shingle_title_3 | Promoter trapping identifies real genes in C. elegans |
| shingle_title_4 | Promoter trapping identifies real genes in C. elegans |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T10:07:17.275Z |
| titel | Promoter trapping identifies real genes in C. elegans |
| titel_suche | Promoter trapping identifies real genes in C. elegans |
| topic | W |
| uid | nat_lic_papers_NLM205536956 |