Characterization of the chromatin structure in the upstream region of the chicken alpha-globin gene domain
| ISSN: |
1617-4623
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| Keywords: |
α-Globin domain ; Hypersensitive sites ; Locus control region ; Chromatin structure
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Biology
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| Notes: |
Abstract The distribution of DNase I hypersensitive sites upstream of the chicken α-globin gene cluster was studied. A group of hypersensitive sites with a complex pattern of tissue specificity, including erythroid-specific elements, was found at a distance of 11.5–14.5 kb upstream of the π gene, the first gene in the cluster. The observations indicate that this area, located upstream of the block of AT-rich sequences and MAR sites (at −8 kb) and upstream of the site of permanent DNA attachment to the nuclear matrix (−3 kb), still belongs to the domain of the α-globin genes.
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| Type of Medium: |
Electronic Resource
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| URL: |