Nephrotoxicity of ifosfamide, carboplatin and etoposide (ICE) alone or combined with extracorporeal or radiant-heat-induced whole-body hyperthermia
Gerke, Peter ; Filejski, Wojciech ; Robins, H. Ian ; Wiedemann, Günther J. ; Steinhoff, Jürgen
Springer
Published 2000
Springer
Published 2000
| ISSN: |
1432-1335
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|---|---|
| Keywords: |
Key words Whole-body hyperthermia ; Nephrotoxicity ; Ifosfamide ; Carboplatin ; Etoposide ; AbbreviationsICE ifosfamide, carboplatin, etoposide ; e-WBH extracorporeal whole-body hyperthemia ; r-WBH radiant-heat-induced whole-body hyperthermia
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract Although whole-body hyperthermia combined with specific genotoxic chemotherapy can be shown to enhance neoplastic cell killing without a concomitant rise in bone marrow toxicity, nephrotoxicity can become treatment-limiting. This study compares the kidney toxicity to the kidney of ifosfamide, carboplatin and etoposide (ICE) chemotherapy alone, and ICE chemotherapy combined with either extracorporeal (e-WBH) or radiant-heat-induced hyperthermia (r-WBH) in 43 patients with refractory sarcoma. Within 3 days of ICE chemotherapy treatment there was a significant increase in urinary protein excretion and a reduction of the glomerular filtration rate. These effects were more pronounced if WBH was added. The use of immunoluminometric assays revealed a predominance of low-molecular-mass proteins. This increase in protein excretion persisted in the e-WBH-treated group, whereas it vanished within 3 weeks in both the group treated with ICE alone and that treated with r-WBH. Our findings suggest that ICE chemotherapy causes transient tubular and glomerular damage, which is enhanced by WBH. In terms of long-term nephrotoxicity e-WBH was more nephrotoxic than r-WBH. This finding is consistent with our clinical observations.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295654382960642 |
|---|---|
| autor | Gerke, Peter Filejski, Wojciech Robins, H. Ian Wiedemann, Günther J. Steinhoff, Jürgen |
| autorsonst | Gerke, Peter Filejski, Wojciech Robins, H. Ian Wiedemann, Günther J. Steinhoff, Jürgen |
| book_url | http://dx.doi.org/10.1007/s004320050028 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM205281524 |
| issn | 1432-1335 |
| journal_name | Journal of cancer research and clinical oncology |
| materialart | 1 |
| notes | Abstract Although whole-body hyperthermia combined with specific genotoxic chemotherapy can be shown to enhance neoplastic cell killing without a concomitant rise in bone marrow toxicity, nephrotoxicity can become treatment-limiting. This study compares the kidney toxicity to the kidney of ifosfamide, carboplatin and etoposide (ICE) chemotherapy alone, and ICE chemotherapy combined with either extracorporeal (e-WBH) or radiant-heat-induced hyperthermia (r-WBH) in 43 patients with refractory sarcoma. Within 3 days of ICE chemotherapy treatment there was a significant increase in urinary protein excretion and a reduction of the glomerular filtration rate. These effects were more pronounced if WBH was added. The use of immunoluminometric assays revealed a predominance of low-molecular-mass proteins. This increase in protein excretion persisted in the e-WBH-treated group, whereas it vanished within 3 weeks in both the group treated with ICE alone and that treated with r-WBH. Our findings suggest that ICE chemotherapy causes transient tubular and glomerular damage, which is enhanced by WBH. In terms of long-term nephrotoxicity e-WBH was more nephrotoxic than r-WBH. This finding is consistent with our clinical observations. |
| package_name | Springer |
| publikationsjahr_anzeige | 2000 |
| publikationsjahr_facette | 2000 |
| publikationsjahr_intervall | 7999:2000-2004 |
| publikationsjahr_sort | 2000 |
| publisher | Springer |
| reference | 126 (2000), S. 173-177 |
| schlagwort | Key words Whole-body hyperthermia Nephrotoxicity Ifosfamide Carboplatin Etoposide AbbreviationsICE ifosfamide, carboplatin, etoposide e-WBH extracorporeal whole-body hyperthemia r-WBH radiant-heat-induced whole-body hyperthermia |
| search_space | articles |
| shingle_author_1 | Gerke, Peter Filejski, Wojciech Robins, H. Ian Wiedemann, Günther J. Steinhoff, Jürgen |
| shingle_author_2 | Gerke, Peter Filejski, Wojciech Robins, H. Ian Wiedemann, Günther J. Steinhoff, Jürgen |
| shingle_author_3 | Gerke, Peter Filejski, Wojciech Robins, H. Ian Wiedemann, Günther J. Steinhoff, Jürgen |
| shingle_author_4 | Gerke, Peter Filejski, Wojciech Robins, H. Ian Wiedemann, Günther J. Steinhoff, Jürgen |
| shingle_catch_all_1 | Gerke, Peter Filejski, Wojciech Robins, H. Ian Wiedemann, Günther J. Steinhoff, Jürgen Nephrotoxicity of ifosfamide, carboplatin and etoposide (ICE) alone or combined with extracorporeal or radiant-heat-induced whole-body hyperthermia Key words Whole-body hyperthermia Nephrotoxicity Ifosfamide Carboplatin Etoposide AbbreviationsICE ifosfamide, carboplatin, etoposide e-WBH extracorporeal whole-body hyperthemia r-WBH radiant-heat-induced whole-body hyperthermia Key words Whole-body hyperthermia Nephrotoxicity Ifosfamide Carboplatin Etoposide AbbreviationsICE ifosfamide, carboplatin, etoposide e-WBH extracorporeal whole-body hyperthemia r-WBH radiant-heat-induced whole-body hyperthermia Abstract Although whole-body hyperthermia combined with specific genotoxic chemotherapy can be shown to enhance neoplastic cell killing without a concomitant rise in bone marrow toxicity, nephrotoxicity can become treatment-limiting. This study compares the kidney toxicity to the kidney of ifosfamide, carboplatin and etoposide (ICE) chemotherapy alone, and ICE chemotherapy combined with either extracorporeal (e-WBH) or radiant-heat-induced hyperthermia (r-WBH) in 43 patients with refractory sarcoma. Within 3 days of ICE chemotherapy treatment there was a significant increase in urinary protein excretion and a reduction of the glomerular filtration rate. These effects were more pronounced if WBH was added. The use of immunoluminometric assays revealed a predominance of low-molecular-mass proteins. This increase in protein excretion persisted in the e-WBH-treated group, whereas it vanished within 3 weeks in both the group treated with ICE alone and that treated with r-WBH. Our findings suggest that ICE chemotherapy causes transient tubular and glomerular damage, which is enhanced by WBH. In terms of long-term nephrotoxicity e-WBH was more nephrotoxic than r-WBH. This finding is consistent with our clinical observations. 1432-1335 14321335 Springer |
| shingle_catch_all_2 | Gerke, Peter Filejski, Wojciech Robins, H. Ian Wiedemann, Günther J. Steinhoff, Jürgen Nephrotoxicity of ifosfamide, carboplatin and etoposide (ICE) alone or combined with extracorporeal or radiant-heat-induced whole-body hyperthermia Key words Whole-body hyperthermia Nephrotoxicity Ifosfamide Carboplatin Etoposide AbbreviationsICE ifosfamide, carboplatin, etoposide e-WBH extracorporeal whole-body hyperthemia r-WBH radiant-heat-induced whole-body hyperthermia Key words Whole-body hyperthermia Nephrotoxicity Ifosfamide Carboplatin Etoposide AbbreviationsICE ifosfamide, carboplatin, etoposide e-WBH extracorporeal whole-body hyperthemia r-WBH radiant-heat-induced whole-body hyperthermia Abstract Although whole-body hyperthermia combined with specific genotoxic chemotherapy can be shown to enhance neoplastic cell killing without a concomitant rise in bone marrow toxicity, nephrotoxicity can become treatment-limiting. This study compares the kidney toxicity to the kidney of ifosfamide, carboplatin and etoposide (ICE) chemotherapy alone, and ICE chemotherapy combined with either extracorporeal (e-WBH) or radiant-heat-induced hyperthermia (r-WBH) in 43 patients with refractory sarcoma. Within 3 days of ICE chemotherapy treatment there was a significant increase in urinary protein excretion and a reduction of the glomerular filtration rate. These effects were more pronounced if WBH was added. The use of immunoluminometric assays revealed a predominance of low-molecular-mass proteins. This increase in protein excretion persisted in the e-WBH-treated group, whereas it vanished within 3 weeks in both the group treated with ICE alone and that treated with r-WBH. Our findings suggest that ICE chemotherapy causes transient tubular and glomerular damage, which is enhanced by WBH. In terms of long-term nephrotoxicity e-WBH was more nephrotoxic than r-WBH. This finding is consistent with our clinical observations. 1432-1335 14321335 Springer |
| shingle_catch_all_3 | Gerke, Peter Filejski, Wojciech Robins, H. Ian Wiedemann, Günther J. Steinhoff, Jürgen Nephrotoxicity of ifosfamide, carboplatin and etoposide (ICE) alone or combined with extracorporeal or radiant-heat-induced whole-body hyperthermia Key words Whole-body hyperthermia Nephrotoxicity Ifosfamide Carboplatin Etoposide AbbreviationsICE ifosfamide, carboplatin, etoposide e-WBH extracorporeal whole-body hyperthemia r-WBH radiant-heat-induced whole-body hyperthermia Key words Whole-body hyperthermia Nephrotoxicity Ifosfamide Carboplatin Etoposide AbbreviationsICE ifosfamide, carboplatin, etoposide e-WBH extracorporeal whole-body hyperthemia r-WBH radiant-heat-induced whole-body hyperthermia Abstract Although whole-body hyperthermia combined with specific genotoxic chemotherapy can be shown to enhance neoplastic cell killing without a concomitant rise in bone marrow toxicity, nephrotoxicity can become treatment-limiting. This study compares the kidney toxicity to the kidney of ifosfamide, carboplatin and etoposide (ICE) chemotherapy alone, and ICE chemotherapy combined with either extracorporeal (e-WBH) or radiant-heat-induced hyperthermia (r-WBH) in 43 patients with refractory sarcoma. Within 3 days of ICE chemotherapy treatment there was a significant increase in urinary protein excretion and a reduction of the glomerular filtration rate. These effects were more pronounced if WBH was added. The use of immunoluminometric assays revealed a predominance of low-molecular-mass proteins. This increase in protein excretion persisted in the e-WBH-treated group, whereas it vanished within 3 weeks in both the group treated with ICE alone and that treated with r-WBH. Our findings suggest that ICE chemotherapy causes transient tubular and glomerular damage, which is enhanced by WBH. In terms of long-term nephrotoxicity e-WBH was more nephrotoxic than r-WBH. This finding is consistent with our clinical observations. 1432-1335 14321335 Springer |
| shingle_catch_all_4 | Gerke, Peter Filejski, Wojciech Robins, H. Ian Wiedemann, Günther J. Steinhoff, Jürgen Nephrotoxicity of ifosfamide, carboplatin and etoposide (ICE) alone or combined with extracorporeal or radiant-heat-induced whole-body hyperthermia Key words Whole-body hyperthermia Nephrotoxicity Ifosfamide Carboplatin Etoposide AbbreviationsICE ifosfamide, carboplatin, etoposide e-WBH extracorporeal whole-body hyperthemia r-WBH radiant-heat-induced whole-body hyperthermia Key words Whole-body hyperthermia Nephrotoxicity Ifosfamide Carboplatin Etoposide AbbreviationsICE ifosfamide, carboplatin, etoposide e-WBH extracorporeal whole-body hyperthemia r-WBH radiant-heat-induced whole-body hyperthermia Abstract Although whole-body hyperthermia combined with specific genotoxic chemotherapy can be shown to enhance neoplastic cell killing without a concomitant rise in bone marrow toxicity, nephrotoxicity can become treatment-limiting. This study compares the kidney toxicity to the kidney of ifosfamide, carboplatin and etoposide (ICE) chemotherapy alone, and ICE chemotherapy combined with either extracorporeal (e-WBH) or radiant-heat-induced hyperthermia (r-WBH) in 43 patients with refractory sarcoma. Within 3 days of ICE chemotherapy treatment there was a significant increase in urinary protein excretion and a reduction of the glomerular filtration rate. These effects were more pronounced if WBH was added. The use of immunoluminometric assays revealed a predominance of low-molecular-mass proteins. This increase in protein excretion persisted in the e-WBH-treated group, whereas it vanished within 3 weeks in both the group treated with ICE alone and that treated with r-WBH. Our findings suggest that ICE chemotherapy causes transient tubular and glomerular damage, which is enhanced by WBH. In terms of long-term nephrotoxicity e-WBH was more nephrotoxic than r-WBH. This finding is consistent with our clinical observations. 1432-1335 14321335 Springer |
| shingle_title_1 | Nephrotoxicity of ifosfamide, carboplatin and etoposide (ICE) alone or combined with extracorporeal or radiant-heat-induced whole-body hyperthermia |
| shingle_title_2 | Nephrotoxicity of ifosfamide, carboplatin and etoposide (ICE) alone or combined with extracorporeal or radiant-heat-induced whole-body hyperthermia |
| shingle_title_3 | Nephrotoxicity of ifosfamide, carboplatin and etoposide (ICE) alone or combined with extracorporeal or radiant-heat-induced whole-body hyperthermia |
| shingle_title_4 | Nephrotoxicity of ifosfamide, carboplatin and etoposide (ICE) alone or combined with extracorporeal or radiant-heat-induced whole-body hyperthermia |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:39:37.544Z |
| titel | Nephrotoxicity of ifosfamide, carboplatin and etoposide (ICE) alone or combined with extracorporeal or radiant-heat-induced whole-body hyperthermia |
| titel_suche | Nephrotoxicity of ifosfamide, carboplatin and etoposide (ICE) alone or combined with extracorporeal or radiant-heat-induced whole-body hyperthermia |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM205281524 |