Effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and its nonpromoting analogue 4-O-methyl-TPA on dorsal dermal melanocytes of the Syrian golden hamster (Mesocricetus auratus)
Goerttler, K. ; Hecker, E. ; Loehrke, H. ; Seip, H. ; Hesse, B. ; Schweitzer, J.
Springer
Published 1982
Springer
Published 1982
| ISSN: |
1432-1335
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|---|---|
| Keywords: |
Two-stage skin carcinogenesis ; DMBA ; TPA ; 4-O-Methyl-TPA ; Melanosis ; Melanomas
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Summary The effect of the tumor promoter TPA and its inactive structural analogue 4-O-methyl-TPA on the induction of dorsal skin melanosis in the normal Syrian golden hamster and on the promotion of melanomas in DMBA-initiated animals was investigated. Both phenomena were observed in TPA-treated hamsters but could not be detected after exposure of animals to 4-O-methyl-TPA. In contrast to results obtained with a variety of other laboratory animals, neither TPA nor 4-O-methyl-TPA were able to induce epidermal hyperplasia of hamster dorsal skin.
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| Type of Medium: |
Electronic Resource
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| URL: |