DWnt-4 and Wingless have distinct activities in the Drosophila dorsal epidermis
Buratovich, M. A. ; Anderson, S. ; Gieseler, K. ; Pradel, J. ; Wilder, E. L.
Springer
Published 2000
Springer
Published 2000
| ISSN: |
1432-041X
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|---|---|
| Keywords: |
Key words DWnt-4 ; Wingless ; Wnt signaling ; Embryonic pattern formation ; Hedgehog
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| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Biology
|
| Notes: |
Abstract Wnt genes are often expressed in overlapping patterns, where they affect a wide array of developmental processes. To address the way in which various Wnt signals elicit distinct effects we compared the activities of two Wnt genes in Drosophila, DWnt-4, and wingless. We show that these Wnt signals produce distinct responses in cells of the dorsal embryonic epidermis. Whereas wingless acts independently of hedgehog signaling in these cells, we show that DWnt-4 requires Hh to elicit its effects. We also show that expression of Wg signal transduction components does not mimic expression of DWnt-4, suggesting that DWnt-4 signaling proceeds through a distinct pathway. The dorsal epidermis may therefore be useful in the identification of novel Wnt signaling components.
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798295373728448512 |
|---|---|
| autor | Buratovich, M. A. Anderson, S. Gieseler, K. Pradel, J. Wilder, E. L. |
| autorsonst | Buratovich, M. A. Anderson, S. Gieseler, K. Pradel, J. Wilder, E. L. |
| book_url | http://dx.doi.org/10.1007/s004270050017 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM204851122 |
| issn | 1432-041X |
| journal_name | Development genes and evolution |
| materialart | 1 |
| notes | Abstract Wnt genes are often expressed in overlapping patterns, where they affect a wide array of developmental processes. To address the way in which various Wnt signals elicit distinct effects we compared the activities of two Wnt genes in Drosophila, DWnt-4, and wingless. We show that these Wnt signals produce distinct responses in cells of the dorsal embryonic epidermis. Whereas wingless acts independently of hedgehog signaling in these cells, we show that DWnt-4 requires Hh to elicit its effects. We also show that expression of Wg signal transduction components does not mimic expression of DWnt-4, suggesting that DWnt-4 signaling proceeds through a distinct pathway. The dorsal epidermis may therefore be useful in the identification of novel Wnt signaling components. |
| package_name | Springer |
| publikationsjahr_anzeige | 2000 |
| publikationsjahr_facette | 2000 |
| publikationsjahr_intervall | 7999:2000-2004 |
| publikationsjahr_sort | 2000 |
| publisher | Springer |
| reference | 210 (2000), S. 111-119 |
| schlagwort | Key words DWnt-4 Wingless Wnt signaling Embryonic pattern formation Hedgehog |
| search_space | articles |
| shingle_author_1 | Buratovich, M. A. Anderson, S. Gieseler, K. Pradel, J. Wilder, E. L. |
| shingle_author_2 | Buratovich, M. A. Anderson, S. Gieseler, K. Pradel, J. Wilder, E. L. |
| shingle_author_3 | Buratovich, M. A. Anderson, S. Gieseler, K. Pradel, J. Wilder, E. L. |
| shingle_author_4 | Buratovich, M. A. Anderson, S. Gieseler, K. Pradel, J. Wilder, E. L. |
| shingle_catch_all_1 | Buratovich, M. A. Anderson, S. Gieseler, K. Pradel, J. Wilder, E. L. DWnt-4 and Wingless have distinct activities in the Drosophila dorsal epidermis Key words DWnt-4 Wingless Wnt signaling Embryonic pattern formation Hedgehog Key words DWnt-4 Wingless Wnt signaling Embryonic pattern formation Hedgehog Abstract Wnt genes are often expressed in overlapping patterns, where they affect a wide array of developmental processes. To address the way in which various Wnt signals elicit distinct effects we compared the activities of two Wnt genes in Drosophila, DWnt-4, and wingless. We show that these Wnt signals produce distinct responses in cells of the dorsal embryonic epidermis. Whereas wingless acts independently of hedgehog signaling in these cells, we show that DWnt-4 requires Hh to elicit its effects. We also show that expression of Wg signal transduction components does not mimic expression of DWnt-4, suggesting that DWnt-4 signaling proceeds through a distinct pathway. The dorsal epidermis may therefore be useful in the identification of novel Wnt signaling components. 1432-041X 1432041X Springer |
| shingle_catch_all_2 | Buratovich, M. A. Anderson, S. Gieseler, K. Pradel, J. Wilder, E. L. DWnt-4 and Wingless have distinct activities in the Drosophila dorsal epidermis Key words DWnt-4 Wingless Wnt signaling Embryonic pattern formation Hedgehog Key words DWnt-4 Wingless Wnt signaling Embryonic pattern formation Hedgehog Abstract Wnt genes are often expressed in overlapping patterns, where they affect a wide array of developmental processes. To address the way in which various Wnt signals elicit distinct effects we compared the activities of two Wnt genes in Drosophila, DWnt-4, and wingless. We show that these Wnt signals produce distinct responses in cells of the dorsal embryonic epidermis. Whereas wingless acts independently of hedgehog signaling in these cells, we show that DWnt-4 requires Hh to elicit its effects. We also show that expression of Wg signal transduction components does not mimic expression of DWnt-4, suggesting that DWnt-4 signaling proceeds through a distinct pathway. The dorsal epidermis may therefore be useful in the identification of novel Wnt signaling components. 1432-041X 1432041X Springer |
| shingle_catch_all_3 | Buratovich, M. A. Anderson, S. Gieseler, K. Pradel, J. Wilder, E. L. DWnt-4 and Wingless have distinct activities in the Drosophila dorsal epidermis Key words DWnt-4 Wingless Wnt signaling Embryonic pattern formation Hedgehog Key words DWnt-4 Wingless Wnt signaling Embryonic pattern formation Hedgehog Abstract Wnt genes are often expressed in overlapping patterns, where they affect a wide array of developmental processes. To address the way in which various Wnt signals elicit distinct effects we compared the activities of two Wnt genes in Drosophila, DWnt-4, and wingless. We show that these Wnt signals produce distinct responses in cells of the dorsal embryonic epidermis. Whereas wingless acts independently of hedgehog signaling in these cells, we show that DWnt-4 requires Hh to elicit its effects. We also show that expression of Wg signal transduction components does not mimic expression of DWnt-4, suggesting that DWnt-4 signaling proceeds through a distinct pathway. The dorsal epidermis may therefore be useful in the identification of novel Wnt signaling components. 1432-041X 1432041X Springer |
| shingle_catch_all_4 | Buratovich, M. A. Anderson, S. Gieseler, K. Pradel, J. Wilder, E. L. DWnt-4 and Wingless have distinct activities in the Drosophila dorsal epidermis Key words DWnt-4 Wingless Wnt signaling Embryonic pattern formation Hedgehog Key words DWnt-4 Wingless Wnt signaling Embryonic pattern formation Hedgehog Abstract Wnt genes are often expressed in overlapping patterns, where they affect a wide array of developmental processes. To address the way in which various Wnt signals elicit distinct effects we compared the activities of two Wnt genes in Drosophila, DWnt-4, and wingless. We show that these Wnt signals produce distinct responses in cells of the dorsal embryonic epidermis. Whereas wingless acts independently of hedgehog signaling in these cells, we show that DWnt-4 requires Hh to elicit its effects. We also show that expression of Wg signal transduction components does not mimic expression of DWnt-4, suggesting that DWnt-4 signaling proceeds through a distinct pathway. The dorsal epidermis may therefore be useful in the identification of novel Wnt signaling components. 1432-041X 1432041X Springer |
| shingle_title_1 | DWnt-4 and Wingless have distinct activities in the Drosophila dorsal epidermis |
| shingle_title_2 | DWnt-4 and Wingless have distinct activities in the Drosophila dorsal epidermis |
| shingle_title_3 | DWnt-4 and Wingless have distinct activities in the Drosophila dorsal epidermis |
| shingle_title_4 | DWnt-4 and Wingless have distinct activities in the Drosophila dorsal epidermis |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:35:11.006Z |
| titel | DWnt-4 and Wingless have distinct activities in the Drosophila dorsal epidermis |
| titel_suche | DWnt-4 and Wingless have distinct activities in the Drosophila dorsal epidermis |
| topic | W |
| uid | nat_lic_papers_NLM204851122 |