Composition of cellular infiltrates in rejected human corneal allografts
Pepose, J. S. ; Nestor, M. S. ; Gardner, K. M. ; Foos, R. Y. ; Pettit, T. H.
Springer
Published 1985
Springer
Published 1985
| ISSN: |
1435-702X
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|---|---|
| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract We utilized the leu series of monoclonal antibodies and an indirect immunoperoxidase technique to quantitate the cellular infiltrates in seven rejected human corneal allografts and compared them to nine identically processed corneas from patients with chronic herpetic stromal keratitis and to three control corneas. The cellular infiltrates in the rejected allografts were of mixed composition, comprised predominantly of leu-1 positive T-lymphocytes and leu-M3 positive macrophages. Both helper and cytotoxic-suppressor T-cells were identified in the stromal lesions. Statistically significant differences were noted in the absolute number of mononuclear cells and macrophages seen infiltrating the rejected corneal allografts compared to the herpetic corneas. We discuss the implications of these findings with regard to possible mechanisms underlying corneal allograft rejection in man.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798296220211347457 |
|---|---|
| autor | Pepose, J. S. Nestor, M. S. Gardner, K. M. Foos, R. Y. Pettit, T. H. |
| autorsonst | Pepose, J. S. Nestor, M. S. Gardner, K. M. Foos, R. Y. Pettit, T. H. |
| book_url | http://dx.doi.org/10.1007/BF02173536 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM20432100X |
| issn | 1435-702X |
| journal_name | Graefe's archive for clinical and experimental ophthalmology |
| materialart | 1 |
| notes | Abstract We utilized the leu series of monoclonal antibodies and an indirect immunoperoxidase technique to quantitate the cellular infiltrates in seven rejected human corneal allografts and compared them to nine identically processed corneas from patients with chronic herpetic stromal keratitis and to three control corneas. The cellular infiltrates in the rejected allografts were of mixed composition, comprised predominantly of leu-1 positive T-lymphocytes and leu-M3 positive macrophages. Both helper and cytotoxic-suppressor T-cells were identified in the stromal lesions. Statistically significant differences were noted in the absolute number of mononuclear cells and macrophages seen infiltrating the rejected corneal allografts compared to the herpetic corneas. We discuss the implications of these findings with regard to possible mechanisms underlying corneal allograft rejection in man. |
| package_name | Springer |
| publikationsjahr_anzeige | 1985 |
| publikationsjahr_facette | 1985 |
| publikationsjahr_intervall | 8014:1985-1989 |
| publikationsjahr_sort | 1985 |
| publisher | Springer |
| reference | 222 (1985), S. 128-133 |
| search_space | articles |
| shingle_author_1 | Pepose, J. S. Nestor, M. S. Gardner, K. M. Foos, R. Y. Pettit, T. H. |
| shingle_author_2 | Pepose, J. S. Nestor, M. S. Gardner, K. M. Foos, R. Y. Pettit, T. H. |
| shingle_author_3 | Pepose, J. S. Nestor, M. S. Gardner, K. M. Foos, R. Y. Pettit, T. H. |
| shingle_author_4 | Pepose, J. S. Nestor, M. S. Gardner, K. M. Foos, R. Y. Pettit, T. H. |
| shingle_catch_all_1 | Pepose, J. S. Nestor, M. S. Gardner, K. M. Foos, R. Y. Pettit, T. H. Composition of cellular infiltrates in rejected human corneal allografts Abstract We utilized the leu series of monoclonal antibodies and an indirect immunoperoxidase technique to quantitate the cellular infiltrates in seven rejected human corneal allografts and compared them to nine identically processed corneas from patients with chronic herpetic stromal keratitis and to three control corneas. The cellular infiltrates in the rejected allografts were of mixed composition, comprised predominantly of leu-1 positive T-lymphocytes and leu-M3 positive macrophages. Both helper and cytotoxic-suppressor T-cells were identified in the stromal lesions. Statistically significant differences were noted in the absolute number of mononuclear cells and macrophages seen infiltrating the rejected corneal allografts compared to the herpetic corneas. We discuss the implications of these findings with regard to possible mechanisms underlying corneal allograft rejection in man. 1435-702X 1435702X Springer |
| shingle_catch_all_2 | Pepose, J. S. Nestor, M. S. Gardner, K. M. Foos, R. Y. Pettit, T. H. Composition of cellular infiltrates in rejected human corneal allografts Abstract We utilized the leu series of monoclonal antibodies and an indirect immunoperoxidase technique to quantitate the cellular infiltrates in seven rejected human corneal allografts and compared them to nine identically processed corneas from patients with chronic herpetic stromal keratitis and to three control corneas. The cellular infiltrates in the rejected allografts were of mixed composition, comprised predominantly of leu-1 positive T-lymphocytes and leu-M3 positive macrophages. Both helper and cytotoxic-suppressor T-cells were identified in the stromal lesions. Statistically significant differences were noted in the absolute number of mononuclear cells and macrophages seen infiltrating the rejected corneal allografts compared to the herpetic corneas. We discuss the implications of these findings with regard to possible mechanisms underlying corneal allograft rejection in man. 1435-702X 1435702X Springer |
| shingle_catch_all_3 | Pepose, J. S. Nestor, M. S. Gardner, K. M. Foos, R. Y. Pettit, T. H. Composition of cellular infiltrates in rejected human corneal allografts Abstract We utilized the leu series of monoclonal antibodies and an indirect immunoperoxidase technique to quantitate the cellular infiltrates in seven rejected human corneal allografts and compared them to nine identically processed corneas from patients with chronic herpetic stromal keratitis and to three control corneas. The cellular infiltrates in the rejected allografts were of mixed composition, comprised predominantly of leu-1 positive T-lymphocytes and leu-M3 positive macrophages. Both helper and cytotoxic-suppressor T-cells were identified in the stromal lesions. Statistically significant differences were noted in the absolute number of mononuclear cells and macrophages seen infiltrating the rejected corneal allografts compared to the herpetic corneas. We discuss the implications of these findings with regard to possible mechanisms underlying corneal allograft rejection in man. 1435-702X 1435702X Springer |
| shingle_catch_all_4 | Pepose, J. S. Nestor, M. S. Gardner, K. M. Foos, R. Y. Pettit, T. H. Composition of cellular infiltrates in rejected human corneal allografts Abstract We utilized the leu series of monoclonal antibodies and an indirect immunoperoxidase technique to quantitate the cellular infiltrates in seven rejected human corneal allografts and compared them to nine identically processed corneas from patients with chronic herpetic stromal keratitis and to three control corneas. The cellular infiltrates in the rejected allografts were of mixed composition, comprised predominantly of leu-1 positive T-lymphocytes and leu-M3 positive macrophages. Both helper and cytotoxic-suppressor T-cells were identified in the stromal lesions. Statistically significant differences were noted in the absolute number of mononuclear cells and macrophages seen infiltrating the rejected corneal allografts compared to the herpetic corneas. We discuss the implications of these findings with regard to possible mechanisms underlying corneal allograft rejection in man. 1435-702X 1435702X Springer |
| shingle_title_1 | Composition of cellular infiltrates in rejected human corneal allografts |
| shingle_title_2 | Composition of cellular infiltrates in rejected human corneal allografts |
| shingle_title_3 | Composition of cellular infiltrates in rejected human corneal allografts |
| shingle_title_4 | Composition of cellular infiltrates in rejected human corneal allografts |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:48:36.842Z |
| titel | Composition of cellular infiltrates in rejected human corneal allografts |
| titel_suche | Composition of cellular infiltrates in rejected human corneal allografts |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM20432100X |