Expression of basic fibroblast growth factor, nerve growth factor, platelet-derived growth factor and transforming growth factor-β in human brain abscess
| ISSN: |
1432-0533
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|---|---|
| Keywords: |
Brain abscess ; Fibroblast growth factor ; Nerve growth factor ; Platelet-derived growth factor ; Transforming growth factor-beta
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract We correlated the histopathological findings of six human brain abscesses with the expression of basic fibroblast growth factor (bFGF), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGFβ). The clinical courses ranged from 1 month to 1 year and viridans streptoccus was the major pathogen. In early abscesses, we demonstrated strong bFGF and moderate NGF and PDGF immunoreactivities in neutrophils and monocytes/macrophages infiltrating the abscess wall and in the fibrin layer lining the abscess center. In the subacute cases, growth of capillaries and fibroblasts into the fibrin layer and deposition of collagen resulted in the formation of a mesodermal layer between the abscess center and the outer gliotic layer. The proliferative non-neural cells (endothelial cells, fibroblasts and glial cells) expressed mild to strong bFGF, NGF and PDGF immunoreactivities, while strong TGFβ staining was seen in the extracellular matrix. A loss of growth factor expression and increased fibrosis was seen in the chronic case. These findings suggest that bFGF, NGF, PDGF and TGFβ produced by the continued influx of leukocytes and by the proliferating non-neural cells may mediate various steps of defense mechanisms and wound healing such as angiogenesis, fibrogenesis and gliosis.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295400940044289 |
|---|---|
| autor | Liu, H. Mei Yang, Hsio Bai Chen, Robert M. |
| autorsonst | Liu, H. Mei Yang, Hsio Bai Chen, Robert M. |
| book_url | http://dx.doi.org/10.1007/BF00294507 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM203612264 |
| issn | 1432-0533 |
| journal_name | Acta neuropathologica |
| materialart | 1 |
| notes | Abstract We correlated the histopathological findings of six human brain abscesses with the expression of basic fibroblast growth factor (bFGF), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGFβ). The clinical courses ranged from 1 month to 1 year and viridans streptoccus was the major pathogen. In early abscesses, we demonstrated strong bFGF and moderate NGF and PDGF immunoreactivities in neutrophils and monocytes/macrophages infiltrating the abscess wall and in the fibrin layer lining the abscess center. In the subacute cases, growth of capillaries and fibroblasts into the fibrin layer and deposition of collagen resulted in the formation of a mesodermal layer between the abscess center and the outer gliotic layer. The proliferative non-neural cells (endothelial cells, fibroblasts and glial cells) expressed mild to strong bFGF, NGF and PDGF immunoreactivities, while strong TGFβ staining was seen in the extracellular matrix. A loss of growth factor expression and increased fibrosis was seen in the chronic case. These findings suggest that bFGF, NGF, PDGF and TGFβ produced by the continued influx of leukocytes and by the proliferating non-neural cells may mediate various steps of defense mechanisms and wound healing such as angiogenesis, fibrogenesis and gliosis. |
| package_name | Springer |
| publikationsjahr_anzeige | 1994 |
| publikationsjahr_facette | 1994 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1994 |
| publisher | Springer |
| reference | 88 (1994), S. 143-150 |
| schlagwort | Brain abscess Fibroblast growth factor Nerve growth factor Platelet-derived growth factor Transforming growth factor-beta |
| search_space | articles |
| shingle_author_1 | Liu, H. Mei Yang, Hsio Bai Chen, Robert M. |
| shingle_author_2 | Liu, H. Mei Yang, Hsio Bai Chen, Robert M. |
| shingle_author_3 | Liu, H. Mei Yang, Hsio Bai Chen, Robert M. |
| shingle_author_4 | Liu, H. Mei Yang, Hsio Bai Chen, Robert M. |
| shingle_catch_all_1 | Liu, H. Mei Yang, Hsio Bai Chen, Robert M. Expression of basic fibroblast growth factor, nerve growth factor, platelet-derived growth factor and transforming growth factor-β in human brain abscess Brain abscess Fibroblast growth factor Nerve growth factor Platelet-derived growth factor Transforming growth factor-beta Brain abscess Fibroblast growth factor Nerve growth factor Platelet-derived growth factor Transforming growth factor-beta Abstract We correlated the histopathological findings of six human brain abscesses with the expression of basic fibroblast growth factor (bFGF), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGFβ). The clinical courses ranged from 1 month to 1 year and viridans streptoccus was the major pathogen. In early abscesses, we demonstrated strong bFGF and moderate NGF and PDGF immunoreactivities in neutrophils and monocytes/macrophages infiltrating the abscess wall and in the fibrin layer lining the abscess center. In the subacute cases, growth of capillaries and fibroblasts into the fibrin layer and deposition of collagen resulted in the formation of a mesodermal layer between the abscess center and the outer gliotic layer. The proliferative non-neural cells (endothelial cells, fibroblasts and glial cells) expressed mild to strong bFGF, NGF and PDGF immunoreactivities, while strong TGFβ staining was seen in the extracellular matrix. A loss of growth factor expression and increased fibrosis was seen in the chronic case. These findings suggest that bFGF, NGF, PDGF and TGFβ produced by the continued influx of leukocytes and by the proliferating non-neural cells may mediate various steps of defense mechanisms and wound healing such as angiogenesis, fibrogenesis and gliosis. 1432-0533 14320533 Springer |
| shingle_catch_all_2 | Liu, H. Mei Yang, Hsio Bai Chen, Robert M. Expression of basic fibroblast growth factor, nerve growth factor, platelet-derived growth factor and transforming growth factor-β in human brain abscess Brain abscess Fibroblast growth factor Nerve growth factor Platelet-derived growth factor Transforming growth factor-beta Brain abscess Fibroblast growth factor Nerve growth factor Platelet-derived growth factor Transforming growth factor-beta Abstract We correlated the histopathological findings of six human brain abscesses with the expression of basic fibroblast growth factor (bFGF), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGFβ). The clinical courses ranged from 1 month to 1 year and viridans streptoccus was the major pathogen. In early abscesses, we demonstrated strong bFGF and moderate NGF and PDGF immunoreactivities in neutrophils and monocytes/macrophages infiltrating the abscess wall and in the fibrin layer lining the abscess center. In the subacute cases, growth of capillaries and fibroblasts into the fibrin layer and deposition of collagen resulted in the formation of a mesodermal layer between the abscess center and the outer gliotic layer. The proliferative non-neural cells (endothelial cells, fibroblasts and glial cells) expressed mild to strong bFGF, NGF and PDGF immunoreactivities, while strong TGFβ staining was seen in the extracellular matrix. A loss of growth factor expression and increased fibrosis was seen in the chronic case. These findings suggest that bFGF, NGF, PDGF and TGFβ produced by the continued influx of leukocytes and by the proliferating non-neural cells may mediate various steps of defense mechanisms and wound healing such as angiogenesis, fibrogenesis and gliosis. 1432-0533 14320533 Springer |
| shingle_catch_all_3 | Liu, H. Mei Yang, Hsio Bai Chen, Robert M. Expression of basic fibroblast growth factor, nerve growth factor, platelet-derived growth factor and transforming growth factor-β in human brain abscess Brain abscess Fibroblast growth factor Nerve growth factor Platelet-derived growth factor Transforming growth factor-beta Brain abscess Fibroblast growth factor Nerve growth factor Platelet-derived growth factor Transforming growth factor-beta Abstract We correlated the histopathological findings of six human brain abscesses with the expression of basic fibroblast growth factor (bFGF), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGFβ). The clinical courses ranged from 1 month to 1 year and viridans streptoccus was the major pathogen. In early abscesses, we demonstrated strong bFGF and moderate NGF and PDGF immunoreactivities in neutrophils and monocytes/macrophages infiltrating the abscess wall and in the fibrin layer lining the abscess center. In the subacute cases, growth of capillaries and fibroblasts into the fibrin layer and deposition of collagen resulted in the formation of a mesodermal layer between the abscess center and the outer gliotic layer. The proliferative non-neural cells (endothelial cells, fibroblasts and glial cells) expressed mild to strong bFGF, NGF and PDGF immunoreactivities, while strong TGFβ staining was seen in the extracellular matrix. A loss of growth factor expression and increased fibrosis was seen in the chronic case. These findings suggest that bFGF, NGF, PDGF and TGFβ produced by the continued influx of leukocytes and by the proliferating non-neural cells may mediate various steps of defense mechanisms and wound healing such as angiogenesis, fibrogenesis and gliosis. 1432-0533 14320533 Springer |
| shingle_catch_all_4 | Liu, H. Mei Yang, Hsio Bai Chen, Robert M. Expression of basic fibroblast growth factor, nerve growth factor, platelet-derived growth factor and transforming growth factor-β in human brain abscess Brain abscess Fibroblast growth factor Nerve growth factor Platelet-derived growth factor Transforming growth factor-beta Brain abscess Fibroblast growth factor Nerve growth factor Platelet-derived growth factor Transforming growth factor-beta Abstract We correlated the histopathological findings of six human brain abscesses with the expression of basic fibroblast growth factor (bFGF), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGFβ). The clinical courses ranged from 1 month to 1 year and viridans streptoccus was the major pathogen. In early abscesses, we demonstrated strong bFGF and moderate NGF and PDGF immunoreactivities in neutrophils and monocytes/macrophages infiltrating the abscess wall and in the fibrin layer lining the abscess center. In the subacute cases, growth of capillaries and fibroblasts into the fibrin layer and deposition of collagen resulted in the formation of a mesodermal layer between the abscess center and the outer gliotic layer. The proliferative non-neural cells (endothelial cells, fibroblasts and glial cells) expressed mild to strong bFGF, NGF and PDGF immunoreactivities, while strong TGFβ staining was seen in the extracellular matrix. A loss of growth factor expression and increased fibrosis was seen in the chronic case. These findings suggest that bFGF, NGF, PDGF and TGFβ produced by the continued influx of leukocytes and by the proliferating non-neural cells may mediate various steps of defense mechanisms and wound healing such as angiogenesis, fibrogenesis and gliosis. 1432-0533 14320533 Springer |
| shingle_title_1 | Expression of basic fibroblast growth factor, nerve growth factor, platelet-derived growth factor and transforming growth factor-β in human brain abscess |
| shingle_title_2 | Expression of basic fibroblast growth factor, nerve growth factor, platelet-derived growth factor and transforming growth factor-β in human brain abscess |
| shingle_title_3 | Expression of basic fibroblast growth factor, nerve growth factor, platelet-derived growth factor and transforming growth factor-β in human brain abscess |
| shingle_title_4 | Expression of basic fibroblast growth factor, nerve growth factor, platelet-derived growth factor and transforming growth factor-β in human brain abscess |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:35:36.087Z |
| titel | Expression of basic fibroblast growth factor, nerve growth factor, platelet-derived growth factor and transforming growth factor-β in human brain abscess |
| titel_suche | Expression of basic fibroblast growth factor, nerve growth factor, platelet-derived growth factor and transforming growth factor-β in human brain abscess |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM203612264 |