S-Antigen immunoreactivity in human pineal glands and pineal parenchymal tumors. A monoclonal antibody study
| ISSN: |
1432-0533
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|---|---|
| Keywords: |
S-Antigen ; Monoclonal antibody ; Pineal gland ; Pineocytoma ; Pineoblastoma
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Summary Using a four-step immunoperoxidase (PAP) method and the monoclonal antibody MAbA9-C6 (MAbA9-C6), which defines an epitope of the retinal S-antigen (S-Ag), we investigated the S-Ag immunoreactivity in human fetal, newborn, infantile and adult pineal glands and in 13 human pineal parenchymal tumors. S-Ag immunoreactivity was demonstrated in a few cells in one of the four fetal and in both infantile glands. Eight of nine adult pineal glands contained isolated MAbA9-C6-positive cells. In two of seven pineocytomas showing neuronal or gangliogliomatous differentiation a few scattered cells displayed S-Ag positivity; two of four pineoblastomas contained small groups of strongly immunoreactive neoplastic cells; two malignant pineocytomas did not demonstrate any S-Ag immunoreactivity. Our results indicate that isolated cells in human pineal gland retain some of the cytochemical characteristics of photoreceptor cells recognized by the MAbA9-C6, and that S-Ag immunoreactivity may be occasionally expressed in pineal parenchymal tumors.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295399178436608 |
|---|---|
| autor | Perentes, E. Rubinstein, L. J. Herman, M. M. Donoso, L. A. |
| autorsonst | Perentes, E. Rubinstein, L. J. Herman, M. M. Donoso, L. A. |
| book_url | http://dx.doi.org/10.1007/BF00688043 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM203595874 |
| issn | 1432-0533 |
| journal_name | Acta neuropathologica |
| materialart | 1 |
| notes | Summary Using a four-step immunoperoxidase (PAP) method and the monoclonal antibody MAbA9-C6 (MAbA9-C6), which defines an epitope of the retinal S-antigen (S-Ag), we investigated the S-Ag immunoreactivity in human fetal, newborn, infantile and adult pineal glands and in 13 human pineal parenchymal tumors. S-Ag immunoreactivity was demonstrated in a few cells in one of the four fetal and in both infantile glands. Eight of nine adult pineal glands contained isolated MAbA9-C6-positive cells. In two of seven pineocytomas showing neuronal or gangliogliomatous differentiation a few scattered cells displayed S-Ag positivity; two of four pineoblastomas contained small groups of strongly immunoreactive neoplastic cells; two malignant pineocytomas did not demonstrate any S-Ag immunoreactivity. Our results indicate that isolated cells in human pineal gland retain some of the cytochemical characteristics of photoreceptor cells recognized by the MAbA9-C6, and that S-Ag immunoreactivity may be occasionally expressed in pineal parenchymal tumors. |
| package_name | Springer |
| publikationsjahr_anzeige | 1986 |
| publikationsjahr_facette | 1986 |
| publikationsjahr_intervall | 8014:1985-1989 |
| publikationsjahr_sort | 1986 |
| publisher | Springer |
| reference | 71 (1986), S. 224-227 |
| schlagwort | S-Antigen Monoclonal antibody Pineal gland Pineocytoma Pineoblastoma |
| search_space | articles |
| shingle_author_1 | Perentes, E. Rubinstein, L. J. Herman, M. M. Donoso, L. A. |
| shingle_author_2 | Perentes, E. Rubinstein, L. J. Herman, M. M. Donoso, L. A. |
| shingle_author_3 | Perentes, E. Rubinstein, L. J. Herman, M. M. Donoso, L. A. |
| shingle_author_4 | Perentes, E. Rubinstein, L. J. Herman, M. M. Donoso, L. A. |
| shingle_catch_all_1 | Perentes, E. Rubinstein, L. J. Herman, M. M. Donoso, L. A. S-Antigen immunoreactivity in human pineal glands and pineal parenchymal tumors. A monoclonal antibody study S-Antigen Monoclonal antibody Pineal gland Pineocytoma Pineoblastoma S-Antigen Monoclonal antibody Pineal gland Pineocytoma Pineoblastoma Summary Using a four-step immunoperoxidase (PAP) method and the monoclonal antibody MAbA9-C6 (MAbA9-C6), which defines an epitope of the retinal S-antigen (S-Ag), we investigated the S-Ag immunoreactivity in human fetal, newborn, infantile and adult pineal glands and in 13 human pineal parenchymal tumors. S-Ag immunoreactivity was demonstrated in a few cells in one of the four fetal and in both infantile glands. Eight of nine adult pineal glands contained isolated MAbA9-C6-positive cells. In two of seven pineocytomas showing neuronal or gangliogliomatous differentiation a few scattered cells displayed S-Ag positivity; two of four pineoblastomas contained small groups of strongly immunoreactive neoplastic cells; two malignant pineocytomas did not demonstrate any S-Ag immunoreactivity. Our results indicate that isolated cells in human pineal gland retain some of the cytochemical characteristics of photoreceptor cells recognized by the MAbA9-C6, and that S-Ag immunoreactivity may be occasionally expressed in pineal parenchymal tumors. 1432-0533 14320533 Springer |
| shingle_catch_all_2 | Perentes, E. Rubinstein, L. J. Herman, M. M. Donoso, L. A. S-Antigen immunoreactivity in human pineal glands and pineal parenchymal tumors. A monoclonal antibody study S-Antigen Monoclonal antibody Pineal gland Pineocytoma Pineoblastoma S-Antigen Monoclonal antibody Pineal gland Pineocytoma Pineoblastoma Summary Using a four-step immunoperoxidase (PAP) method and the monoclonal antibody MAbA9-C6 (MAbA9-C6), which defines an epitope of the retinal S-antigen (S-Ag), we investigated the S-Ag immunoreactivity in human fetal, newborn, infantile and adult pineal glands and in 13 human pineal parenchymal tumors. S-Ag immunoreactivity was demonstrated in a few cells in one of the four fetal and in both infantile glands. Eight of nine adult pineal glands contained isolated MAbA9-C6-positive cells. In two of seven pineocytomas showing neuronal or gangliogliomatous differentiation a few scattered cells displayed S-Ag positivity; two of four pineoblastomas contained small groups of strongly immunoreactive neoplastic cells; two malignant pineocytomas did not demonstrate any S-Ag immunoreactivity. Our results indicate that isolated cells in human pineal gland retain some of the cytochemical characteristics of photoreceptor cells recognized by the MAbA9-C6, and that S-Ag immunoreactivity may be occasionally expressed in pineal parenchymal tumors. 1432-0533 14320533 Springer |
| shingle_catch_all_3 | Perentes, E. Rubinstein, L. J. Herman, M. M. Donoso, L. A. S-Antigen immunoreactivity in human pineal glands and pineal parenchymal tumors. A monoclonal antibody study S-Antigen Monoclonal antibody Pineal gland Pineocytoma Pineoblastoma S-Antigen Monoclonal antibody Pineal gland Pineocytoma Pineoblastoma Summary Using a four-step immunoperoxidase (PAP) method and the monoclonal antibody MAbA9-C6 (MAbA9-C6), which defines an epitope of the retinal S-antigen (S-Ag), we investigated the S-Ag immunoreactivity in human fetal, newborn, infantile and adult pineal glands and in 13 human pineal parenchymal tumors. S-Ag immunoreactivity was demonstrated in a few cells in one of the four fetal and in both infantile glands. Eight of nine adult pineal glands contained isolated MAbA9-C6-positive cells. In two of seven pineocytomas showing neuronal or gangliogliomatous differentiation a few scattered cells displayed S-Ag positivity; two of four pineoblastomas contained small groups of strongly immunoreactive neoplastic cells; two malignant pineocytomas did not demonstrate any S-Ag immunoreactivity. Our results indicate that isolated cells in human pineal gland retain some of the cytochemical characteristics of photoreceptor cells recognized by the MAbA9-C6, and that S-Ag immunoreactivity may be occasionally expressed in pineal parenchymal tumors. 1432-0533 14320533 Springer |
| shingle_catch_all_4 | Perentes, E. Rubinstein, L. J. Herman, M. M. Donoso, L. A. S-Antigen immunoreactivity in human pineal glands and pineal parenchymal tumors. A monoclonal antibody study S-Antigen Monoclonal antibody Pineal gland Pineocytoma Pineoblastoma S-Antigen Monoclonal antibody Pineal gland Pineocytoma Pineoblastoma Summary Using a four-step immunoperoxidase (PAP) method and the monoclonal antibody MAbA9-C6 (MAbA9-C6), which defines an epitope of the retinal S-antigen (S-Ag), we investigated the S-Ag immunoreactivity in human fetal, newborn, infantile and adult pineal glands and in 13 human pineal parenchymal tumors. S-Ag immunoreactivity was demonstrated in a few cells in one of the four fetal and in both infantile glands. Eight of nine adult pineal glands contained isolated MAbA9-C6-positive cells. In two of seven pineocytomas showing neuronal or gangliogliomatous differentiation a few scattered cells displayed S-Ag positivity; two of four pineoblastomas contained small groups of strongly immunoreactive neoplastic cells; two malignant pineocytomas did not demonstrate any S-Ag immunoreactivity. Our results indicate that isolated cells in human pineal gland retain some of the cytochemical characteristics of photoreceptor cells recognized by the MAbA9-C6, and that S-Ag immunoreactivity may be occasionally expressed in pineal parenchymal tumors. 1432-0533 14320533 Springer |
| shingle_title_1 | S-Antigen immunoreactivity in human pineal glands and pineal parenchymal tumors. A monoclonal antibody study |
| shingle_title_2 | S-Antigen immunoreactivity in human pineal glands and pineal parenchymal tumors. A monoclonal antibody study |
| shingle_title_3 | S-Antigen immunoreactivity in human pineal glands and pineal parenchymal tumors. A monoclonal antibody study |
| shingle_title_4 | S-Antigen immunoreactivity in human pineal glands and pineal parenchymal tumors. A monoclonal antibody study |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:35:34.701Z |
| titel | S-Antigen immunoreactivity in human pineal glands and pineal parenchymal tumors. A monoclonal antibody study |
| titel_suche | S-Antigen immunoreactivity in human pineal glands and pineal parenchymal tumors. A monoclonal antibody study |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM203595874 |