Evolution of neuronal changes in metachromatic leukodystrophy
| ISSN: |
1432-0533
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|---|---|
| Keywords: |
Metachromatic Leukodystrophy ; Neuronal Inclusions ; Laminated Bodies ; Mucopolysaecharides ; Electron Microscopy
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Summary The ultrastructural findings of the metachromatic granules in the anterior horn cells of the spinal cord in a case of metachromatic leukodystrophy are presented. The typical neuronal inclusions are concentrically laminated bodies of approximately 1 μ. In addition various morphological variations of the abnormal inclusions are seen side by side in the same neuron and give the impression that the highly organized laminated bodies are formed as a result of progressive deposition of membranous material upon a nidas which is initially amorphous, which then becomes granular, fibrillar or horizontally striped and finally multilaminated. Material capable of binding colloidal iron particles is demonstrated in these inclusions, and suggests the presence of mucopolysaccharides.
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| Type of Medium: |
Electronic Resource
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| URL: |