Ultrasound-guided percutaneous laser ablation of liver tissue in a rabbit model
Pacella, C. M. ; Rossi, Z. ; Bizzarri, G. ; Papini, E. ; Marinozzi, V. ; Paliotta, D. ; Castaldo, P. ; Ziparo, V. ; Garosi, F. ; Cinti, M. ; Muzzi, F.
Springer
Published 1993
Springer
Published 1993
| ISSN: |
1432-1084
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|---|---|
| Keywords: |
Liver, interventional procedures ; Lasers ; Liver, US studies ; Liver neoplasms, therapy ; Hyperthermia
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract The present report evaluates the efficacy and safety of percutaneous interstitial laser tissue ablation of the liver in nine New Zealand rabbits. A Nd: YAG laser was coupled to a quartz fibreoptic guide (600 μm) with a flat tip. The fibre and a thermocouple were placed in the lumen of two Chiba needles (18G) and these were inserted into the liver 10 mm apart under ultrasound guidance. The laser was fired for 5 min at 1, 3 and 5 W power, respectively, in three groups of rabbits. There were no acute complications and all the rabbits except one survived until the established time of sacrifice. The procedure induced a cavity surrounded by a zone (about 10 mm) of coagulative necrosis. After 2 weeks a strong peripheral inflammatory response was evident and after 4 weeks a capsule of connective tissue enclosed the lesions. Our study seems to offer a safe and rapid technique producing a “guaranteed kill radius” for the treatment of small hepatic neoplasms.
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| Type of Medium: |
Electronic Resource
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| URL: |