Oral trofosfamide: an active drug in the treatment of soft-tissue sarcoma
Blomqvist, C. ; Wiklund, T. ; Pajunen, Marjo ; Virolainen, Martti ; Elomaa, Inkeri
Springer
Published 1995
Springer
Published 1995
| ISSN: |
1432-0843
|
|---|---|
| Keywords: |
Key words Soft-tissue sarcoma ; Chemotherapy ; Trofosfamide
|
| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Medicine
|
| Notes: |
Abstract A total of 23 patients with metastatic sarcomas were treated with continuous oral trofosfamide, an alkylating agent structurally related to cyclophosphamide and ifosfamide. In all, 12 of the patients were chemotherapy–naive. Doses were escalated every 3rd week until the development of leukopenia of WHO grade 2. The treatment was well tolerated and produced little subjective toxicity. Leukopenia was the dose-limiting toxicity. The daily dose that produced grade 2 leukopenia was 200–250 mg in 65% of the patients. Three patients responded, all of whom had been treated with trofosfamide as first-line treatment.
|
| Type of Medium: |
Electronic Resource
|
| URL: |