The multidrug-resistance gene in gene therapy of cancer and hematopoietic disorders
| ISSN: |
1432-0584
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| Keywords: |
Key words Chemotherapy ; Myelosuppression ; Hematopoietic stem cells ; P-glycoprotein ; Dihydrofolate reductase
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract Chemoresistance genes have been identified as an impediment to anticancer drug treatment. In particular, P-glycoprotein, the product of the multidrug-resistance (MDR1) gene, plays a major role in clinical treatment failure. Conversely, expression of an MDR1 cDNA in bone marrow of transgenic animals renders hematopoietic cells chemoresistant. Efficient transfer of drug-resistance genes to normal hematopoietic progenitor cells has been achieved with the use of retroviral vectors. In this article we review approaches which use the multidrug-resistance gene to protect bone marrow from myelosuppression following chemotherapy and as a selectable markerin vivo to increase the expression of nonselectable genes which correct hereditary diseases of the hematopoietic system.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295418839236608 |
|---|---|
| autor | Licht, T. Pastan, I. Gottesman, M. M. Herrmann, F. |
| autorsonst | Licht, T. Pastan, I. Gottesman, M. M. Herrmann, F. |
| book_url | http://dx.doi.org/10.1007/s002770050159 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM202978109 |
| issn | 1432-0584 |
| journal_name | Annals of hematology |
| materialart | 1 |
| notes | Abstract Chemoresistance genes have been identified as an impediment to anticancer drug treatment. In particular, P-glycoprotein, the product of the multidrug-resistance (MDR1) gene, plays a major role in clinical treatment failure. Conversely, expression of an MDR1 cDNA in bone marrow of transgenic animals renders hematopoietic cells chemoresistant. Efficient transfer of drug-resistance genes to normal hematopoietic progenitor cells has been achieved with the use of retroviral vectors. In this article we review approaches which use the multidrug-resistance gene to protect bone marrow from myelosuppression following chemotherapy and as a selectable markerin vivo to increase the expression of nonselectable genes which correct hereditary diseases of the hematopoietic system. |
| package_name | Springer |
| publikationsjahr_anzeige | 1996 |
| publikationsjahr_facette | 1996 |
| publikationsjahr_intervall | 8004:1995-1999 |
| publikationsjahr_sort | 1996 |
| publisher | Springer |
| reference | 72 (1996), S. 184-193 |
| schlagwort | Key words Chemotherapy Myelosuppression Hematopoietic stem cells P-glycoprotein Dihydrofolate reductase |
| search_space | articles |
| shingle_author_1 | Licht, T. Pastan, I. Gottesman, M. M. Herrmann, F. |
| shingle_author_2 | Licht, T. Pastan, I. Gottesman, M. M. Herrmann, F. |
| shingle_author_3 | Licht, T. Pastan, I. Gottesman, M. M. Herrmann, F. |
| shingle_author_4 | Licht, T. Pastan, I. Gottesman, M. M. Herrmann, F. |
| shingle_catch_all_1 | Licht, T. Pastan, I. Gottesman, M. M. Herrmann, F. The multidrug-resistance gene in gene therapy of cancer and hematopoietic disorders Key words Chemotherapy Myelosuppression Hematopoietic stem cells P-glycoprotein Dihydrofolate reductase Key words Chemotherapy Myelosuppression Hematopoietic stem cells P-glycoprotein Dihydrofolate reductase Abstract Chemoresistance genes have been identified as an impediment to anticancer drug treatment. In particular, P-glycoprotein, the product of the multidrug-resistance (MDR1) gene, plays a major role in clinical treatment failure. Conversely, expression of an MDR1 cDNA in bone marrow of transgenic animals renders hematopoietic cells chemoresistant. Efficient transfer of drug-resistance genes to normal hematopoietic progenitor cells has been achieved with the use of retroviral vectors. In this article we review approaches which use the multidrug-resistance gene to protect bone marrow from myelosuppression following chemotherapy and as a selectable markerin vivo to increase the expression of nonselectable genes which correct hereditary diseases of the hematopoietic system. 1432-0584 14320584 Springer |
| shingle_catch_all_2 | Licht, T. Pastan, I. Gottesman, M. M. Herrmann, F. The multidrug-resistance gene in gene therapy of cancer and hematopoietic disorders Key words Chemotherapy Myelosuppression Hematopoietic stem cells P-glycoprotein Dihydrofolate reductase Key words Chemotherapy Myelosuppression Hematopoietic stem cells P-glycoprotein Dihydrofolate reductase Abstract Chemoresistance genes have been identified as an impediment to anticancer drug treatment. In particular, P-glycoprotein, the product of the multidrug-resistance (MDR1) gene, plays a major role in clinical treatment failure. Conversely, expression of an MDR1 cDNA in bone marrow of transgenic animals renders hematopoietic cells chemoresistant. Efficient transfer of drug-resistance genes to normal hematopoietic progenitor cells has been achieved with the use of retroviral vectors. In this article we review approaches which use the multidrug-resistance gene to protect bone marrow from myelosuppression following chemotherapy and as a selectable markerin vivo to increase the expression of nonselectable genes which correct hereditary diseases of the hematopoietic system. 1432-0584 14320584 Springer |
| shingle_catch_all_3 | Licht, T. Pastan, I. Gottesman, M. M. Herrmann, F. The multidrug-resistance gene in gene therapy of cancer and hematopoietic disorders Key words Chemotherapy Myelosuppression Hematopoietic stem cells P-glycoprotein Dihydrofolate reductase Key words Chemotherapy Myelosuppression Hematopoietic stem cells P-glycoprotein Dihydrofolate reductase Abstract Chemoresistance genes have been identified as an impediment to anticancer drug treatment. In particular, P-glycoprotein, the product of the multidrug-resistance (MDR1) gene, plays a major role in clinical treatment failure. Conversely, expression of an MDR1 cDNA in bone marrow of transgenic animals renders hematopoietic cells chemoresistant. Efficient transfer of drug-resistance genes to normal hematopoietic progenitor cells has been achieved with the use of retroviral vectors. In this article we review approaches which use the multidrug-resistance gene to protect bone marrow from myelosuppression following chemotherapy and as a selectable markerin vivo to increase the expression of nonselectable genes which correct hereditary diseases of the hematopoietic system. 1432-0584 14320584 Springer |
| shingle_catch_all_4 | Licht, T. Pastan, I. Gottesman, M. M. Herrmann, F. The multidrug-resistance gene in gene therapy of cancer and hematopoietic disorders Key words Chemotherapy Myelosuppression Hematopoietic stem cells P-glycoprotein Dihydrofolate reductase Key words Chemotherapy Myelosuppression Hematopoietic stem cells P-glycoprotein Dihydrofolate reductase Abstract Chemoresistance genes have been identified as an impediment to anticancer drug treatment. In particular, P-glycoprotein, the product of the multidrug-resistance (MDR1) gene, plays a major role in clinical treatment failure. Conversely, expression of an MDR1 cDNA in bone marrow of transgenic animals renders hematopoietic cells chemoresistant. Efficient transfer of drug-resistance genes to normal hematopoietic progenitor cells has been achieved with the use of retroviral vectors. In this article we review approaches which use the multidrug-resistance gene to protect bone marrow from myelosuppression following chemotherapy and as a selectable markerin vivo to increase the expression of nonselectable genes which correct hereditary diseases of the hematopoietic system. 1432-0584 14320584 Springer |
| shingle_title_1 | The multidrug-resistance gene in gene therapy of cancer and hematopoietic disorders |
| shingle_title_2 | The multidrug-resistance gene in gene therapy of cancer and hematopoietic disorders |
| shingle_title_3 | The multidrug-resistance gene in gene therapy of cancer and hematopoietic disorders |
| shingle_title_4 | The multidrug-resistance gene in gene therapy of cancer and hematopoietic disorders |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:35:53.787Z |
| titel | The multidrug-resistance gene in gene therapy of cancer and hematopoietic disorders |
| titel_suche | The multidrug-resistance gene in gene therapy of cancer and hematopoietic disorders |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM202978109 |