Ineffective erythropoiesis in acute human P. falciparum malaria
| ISSN: |
1432-0584
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|---|---|
| Keywords: |
Malaria ; Anemia ; Ineffective erythropoiesis ; Proliferation kinetics ; Quantitative autoradiography
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Summary An analysis of erythroblast cell kinetics utilizing quantitative 14C-autoradiography has been performed in five cases of acute Plasmodium falciparum malaria prior to and, in four patients, 3 or 6 days after the onset of antimalarial therapy. Associated with no or only moderate anemia were changes of erythroblast morphology, a considerable shift in the frequency of red and white blood cell precursors in the bone marrow, and a reduced rate of erythroblast proliferation. There was a marked loss of polychromatic erythroblasts, which was smaller but still detectable during the therapeutic phase. The results provide some quantitative data on the extent of “parenchymal damage” of bone marrow and stress the impact of ineffective erythropoiesis and reduced rate of erythropoietic proliferation on the emergence of anemia in Plasmodium falciparum malaria.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295416171659267 |
|---|---|
| autor | Dörmer, P. Dietrich, M. Kern, P. Horstmann, R. D. |
| autorsonst | Dörmer, P. Dietrich, M. Kern, P. Horstmann, R. D. |
| book_url | http://dx.doi.org/10.1007/BF00319868 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM202957209 |
| issn | 1432-0584 |
| journal_name | Annals of hematology |
| materialart | 1 |
| notes | Summary An analysis of erythroblast cell kinetics utilizing quantitative 14C-autoradiography has been performed in five cases of acute Plasmodium falciparum malaria prior to and, in four patients, 3 or 6 days after the onset of antimalarial therapy. Associated with no or only moderate anemia were changes of erythroblast morphology, a considerable shift in the frequency of red and white blood cell precursors in the bone marrow, and a reduced rate of erythroblast proliferation. There was a marked loss of polychromatic erythroblasts, which was smaller but still detectable during the therapeutic phase. The results provide some quantitative data on the extent of “parenchymal damage” of bone marrow and stress the impact of ineffective erythropoiesis and reduced rate of erythropoietic proliferation on the emergence of anemia in Plasmodium falciparum malaria. |
| package_name | Springer |
| publikationsjahr_anzeige | 1983 |
| publikationsjahr_facette | 1983 |
| publikationsjahr_intervall | 8019:1980-1984 |
| publikationsjahr_sort | 1983 |
| publisher | Springer |
| reference | 46 (1983), S. 279-288 |
| schlagwort | Malaria Anemia Ineffective erythropoiesis Proliferation kinetics Quantitative autoradiography |
| search_space | articles |
| shingle_author_1 | Dörmer, P. Dietrich, M. Kern, P. Horstmann, R. D. |
| shingle_author_2 | Dörmer, P. Dietrich, M. Kern, P. Horstmann, R. D. |
| shingle_author_3 | Dörmer, P. Dietrich, M. Kern, P. Horstmann, R. D. |
| shingle_author_4 | Dörmer, P. Dietrich, M. Kern, P. Horstmann, R. D. |
| shingle_catch_all_1 | Dörmer, P. Dietrich, M. Kern, P. Horstmann, R. D. Ineffective erythropoiesis in acute human P. falciparum malaria Malaria Anemia Ineffective erythropoiesis Proliferation kinetics Quantitative autoradiography Malaria Anemia Ineffective erythropoiesis Proliferation kinetics Quantitative autoradiography Summary An analysis of erythroblast cell kinetics utilizing quantitative 14C-autoradiography has been performed in five cases of acute Plasmodium falciparum malaria prior to and, in four patients, 3 or 6 days after the onset of antimalarial therapy. Associated with no or only moderate anemia were changes of erythroblast morphology, a considerable shift in the frequency of red and white blood cell precursors in the bone marrow, and a reduced rate of erythroblast proliferation. There was a marked loss of polychromatic erythroblasts, which was smaller but still detectable during the therapeutic phase. The results provide some quantitative data on the extent of “parenchymal damage” of bone marrow and stress the impact of ineffective erythropoiesis and reduced rate of erythropoietic proliferation on the emergence of anemia in Plasmodium falciparum malaria. 1432-0584 14320584 Springer |
| shingle_catch_all_2 | Dörmer, P. Dietrich, M. Kern, P. Horstmann, R. D. Ineffective erythropoiesis in acute human P. falciparum malaria Malaria Anemia Ineffective erythropoiesis Proliferation kinetics Quantitative autoradiography Malaria Anemia Ineffective erythropoiesis Proliferation kinetics Quantitative autoradiography Summary An analysis of erythroblast cell kinetics utilizing quantitative 14C-autoradiography has been performed in five cases of acute Plasmodium falciparum malaria prior to and, in four patients, 3 or 6 days after the onset of antimalarial therapy. Associated with no or only moderate anemia were changes of erythroblast morphology, a considerable shift in the frequency of red and white blood cell precursors in the bone marrow, and a reduced rate of erythroblast proliferation. There was a marked loss of polychromatic erythroblasts, which was smaller but still detectable during the therapeutic phase. The results provide some quantitative data on the extent of “parenchymal damage” of bone marrow and stress the impact of ineffective erythropoiesis and reduced rate of erythropoietic proliferation on the emergence of anemia in Plasmodium falciparum malaria. 1432-0584 14320584 Springer |
| shingle_catch_all_3 | Dörmer, P. Dietrich, M. Kern, P. Horstmann, R. D. Ineffective erythropoiesis in acute human P. falciparum malaria Malaria Anemia Ineffective erythropoiesis Proliferation kinetics Quantitative autoradiography Malaria Anemia Ineffective erythropoiesis Proliferation kinetics Quantitative autoradiography Summary An analysis of erythroblast cell kinetics utilizing quantitative 14C-autoradiography has been performed in five cases of acute Plasmodium falciparum malaria prior to and, in four patients, 3 or 6 days after the onset of antimalarial therapy. Associated with no or only moderate anemia were changes of erythroblast morphology, a considerable shift in the frequency of red and white blood cell precursors in the bone marrow, and a reduced rate of erythroblast proliferation. There was a marked loss of polychromatic erythroblasts, which was smaller but still detectable during the therapeutic phase. The results provide some quantitative data on the extent of “parenchymal damage” of bone marrow and stress the impact of ineffective erythropoiesis and reduced rate of erythropoietic proliferation on the emergence of anemia in Plasmodium falciparum malaria. 1432-0584 14320584 Springer |
| shingle_catch_all_4 | Dörmer, P. Dietrich, M. Kern, P. Horstmann, R. D. Ineffective erythropoiesis in acute human P. falciparum malaria Malaria Anemia Ineffective erythropoiesis Proliferation kinetics Quantitative autoradiography Malaria Anemia Ineffective erythropoiesis Proliferation kinetics Quantitative autoradiography Summary An analysis of erythroblast cell kinetics utilizing quantitative 14C-autoradiography has been performed in five cases of acute Plasmodium falciparum malaria prior to and, in four patients, 3 or 6 days after the onset of antimalarial therapy. Associated with no or only moderate anemia were changes of erythroblast morphology, a considerable shift in the frequency of red and white blood cell precursors in the bone marrow, and a reduced rate of erythroblast proliferation. There was a marked loss of polychromatic erythroblasts, which was smaller but still detectable during the therapeutic phase. The results provide some quantitative data on the extent of “parenchymal damage” of bone marrow and stress the impact of ineffective erythropoiesis and reduced rate of erythropoietic proliferation on the emergence of anemia in Plasmodium falciparum malaria. 1432-0584 14320584 Springer |
| shingle_title_1 | Ineffective erythropoiesis in acute human P. falciparum malaria |
| shingle_title_2 | Ineffective erythropoiesis in acute human P. falciparum malaria |
| shingle_title_3 | Ineffective erythropoiesis in acute human P. falciparum malaria |
| shingle_title_4 | Ineffective erythropoiesis in acute human P. falciparum malaria |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:35:51.478Z |
| titel | Ineffective erythropoiesis in acute human P. falciparum malaria |
| titel_suche | Ineffective erythropoiesis in acute human P. falciparum malaria |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM202957209 |