A prospective evaluation of OC125 and magnetic resonance imaging in patients with ovarian carcinoma
Perkins, A. C. ; Powell, M. C. ; Wastie, M. L. ; Scott, I. V. ; Hitchcock, A. ; Worthington, B. S. ; Symonds, E. M.
Springer
Published 1990
Springer
Published 1990
| ISSN: |
1619-7089
|
|---|---|
| Keywords: |
Magnetic resonance imaging ; Immunoscintigraphy ; Ovarian carcinoma
|
| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Medicine
|
| Notes: |
Abstract Eighteen patients with suspected primary or recurrent ovarian carcinoma have been investigated in each case by the assay of serum levels of the antigen CA125, immunoscintigraphy using131I-OC125 antibody and magnetic resonance imaging using a 0.15 Tesla-system. The final diagnosis was confirmed by laparotomy or laparoscopy. Serum levels of CA125 ranged between 5 and 780 units/ml (normal range 〈 35). Antibody images and MRI were truly positive in 11 patients, 2 of whom were subsequently found to have bowel tumours. MRI showed greater detail of smaller lesions whilst immunoscintigraphy was more suited to the detection of distant metastases. In 7 patients the antibody images were positive whilst the serum marker levels were normal. This pilot study provides a preliminary comparison of the more recent techniques currently being evaluated for the detection of ovarian carcinoma.
|
| Type of Medium: |
Electronic Resource
|
| URL: |