Reconversion of bone marrow in Gaucher disease treated with enzyme therapy documented by MR
Allison, J. W. ; James, Charles A. ; Arnold, G. L. ; Stine, Kimo C. ; Becton, David L. ; Bell, J. M.
Springer
Published 1998
Springer
Published 1998
| ISSN: |
1432-1998
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|---|---|
| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract Background. Skeletal complications are responsible for significant morbidity in Gaucher patients. Plain radiographs have been unreliable in assessing bone marrow infiltration and activity. A way to assess bone marrow improvement is needed during enzyme therapy. Objective. The purpose of this paper is to assess the usefulness of MR in following improvement of abnormal bone marrow in Gaucher patients on enzyme therapy. Materials and methods. Three patients aged 2, 7, and 24 years underwent serial MR scans of the lower extremities before and during treatment with Alglucerase (two patients) and Imiglucerase (one patient). T1-weighted, T2-weighted, STIR and FSE T2-weighted images were utilized. Two patients were imaged after 16 months of therapy, and one patient was imaged after 6 months of therapy. Results. All patients had improvement in marrow signal consistent with partial reconversion to fatty marrow during treatment. The findings were more marked after prolonged therapy. T1-weighted images demonstrated findings most clearly. Conclusion. MR consistently showed improvement in marrow signal in Gaucher patients on enzyme therapy. As smaller doses of enzyme therapy are the trend, MR can be utilized to determine if therapy is effecting a change in the bone marrow.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295875477307392 |
|---|---|
| autor | Allison, J. W. James, Charles A. Arnold, G. L. Stine, Kimo C. Becton, David L. Bell, J. M. |
| autorsonst | Allison, J. W. James, Charles A. Arnold, G. L. Stine, Kimo C. Becton, David L. Bell, J. M. |
| book_url | http://dx.doi.org/10.1007/s002470050340 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM202644022 |
| issn | 1432-1998 |
| journal_name | Pediatric radiology |
| materialart | 1 |
| notes | Abstract Background. Skeletal complications are responsible for significant morbidity in Gaucher patients. Plain radiographs have been unreliable in assessing bone marrow infiltration and activity. A way to assess bone marrow improvement is needed during enzyme therapy. Objective. The purpose of this paper is to assess the usefulness of MR in following improvement of abnormal bone marrow in Gaucher patients on enzyme therapy. Materials and methods. Three patients aged 2, 7, and 24 years underwent serial MR scans of the lower extremities before and during treatment with Alglucerase (two patients) and Imiglucerase (one patient). T1-weighted, T2-weighted, STIR and FSE T2-weighted images were utilized. Two patients were imaged after 16 months of therapy, and one patient was imaged after 6 months of therapy. Results. All patients had improvement in marrow signal consistent with partial reconversion to fatty marrow during treatment. The findings were more marked after prolonged therapy. T1-weighted images demonstrated findings most clearly. Conclusion. MR consistently showed improvement in marrow signal in Gaucher patients on enzyme therapy. As smaller doses of enzyme therapy are the trend, MR can be utilized to determine if therapy is effecting a change in the bone marrow. |
| package_name | Springer |
| publikationsjahr_anzeige | 1998 |
| publikationsjahr_facette | 1998 |
| publikationsjahr_intervall | 8004:1995-1999 |
| publikationsjahr_sort | 1998 |
| publisher | Springer |
| reference | 28 (1998), S. 237-240 |
| search_space | articles |
| shingle_author_1 | Allison, J. W. James, Charles A. Arnold, G. L. Stine, Kimo C. Becton, David L. Bell, J. M. |
| shingle_author_2 | Allison, J. W. James, Charles A. Arnold, G. L. Stine, Kimo C. Becton, David L. Bell, J. M. |
| shingle_author_3 | Allison, J. W. James, Charles A. Arnold, G. L. Stine, Kimo C. Becton, David L. Bell, J. M. |
| shingle_author_4 | Allison, J. W. James, Charles A. Arnold, G. L. Stine, Kimo C. Becton, David L. Bell, J. M. |
| shingle_catch_all_1 | Allison, J. W. James, Charles A. Arnold, G. L. Stine, Kimo C. Becton, David L. Bell, J. M. Reconversion of bone marrow in Gaucher disease treated with enzyme therapy documented by MR Abstract Background. Skeletal complications are responsible for significant morbidity in Gaucher patients. Plain radiographs have been unreliable in assessing bone marrow infiltration and activity. A way to assess bone marrow improvement is needed during enzyme therapy. Objective. The purpose of this paper is to assess the usefulness of MR in following improvement of abnormal bone marrow in Gaucher patients on enzyme therapy. Materials and methods. Three patients aged 2, 7, and 24 years underwent serial MR scans of the lower extremities before and during treatment with Alglucerase (two patients) and Imiglucerase (one patient). T1-weighted, T2-weighted, STIR and FSE T2-weighted images were utilized. Two patients were imaged after 16 months of therapy, and one patient was imaged after 6 months of therapy. Results. All patients had improvement in marrow signal consistent with partial reconversion to fatty marrow during treatment. The findings were more marked after prolonged therapy. T1-weighted images demonstrated findings most clearly. Conclusion. MR consistently showed improvement in marrow signal in Gaucher patients on enzyme therapy. As smaller doses of enzyme therapy are the trend, MR can be utilized to determine if therapy is effecting a change in the bone marrow. 1432-1998 14321998 Springer |
| shingle_catch_all_2 | Allison, J. W. James, Charles A. Arnold, G. L. Stine, Kimo C. Becton, David L. Bell, J. M. Reconversion of bone marrow in Gaucher disease treated with enzyme therapy documented by MR Abstract Background. Skeletal complications are responsible for significant morbidity in Gaucher patients. Plain radiographs have been unreliable in assessing bone marrow infiltration and activity. A way to assess bone marrow improvement is needed during enzyme therapy. Objective. The purpose of this paper is to assess the usefulness of MR in following improvement of abnormal bone marrow in Gaucher patients on enzyme therapy. Materials and methods. Three patients aged 2, 7, and 24 years underwent serial MR scans of the lower extremities before and during treatment with Alglucerase (two patients) and Imiglucerase (one patient). T1-weighted, T2-weighted, STIR and FSE T2-weighted images were utilized. Two patients were imaged after 16 months of therapy, and one patient was imaged after 6 months of therapy. Results. All patients had improvement in marrow signal consistent with partial reconversion to fatty marrow during treatment. The findings were more marked after prolonged therapy. T1-weighted images demonstrated findings most clearly. Conclusion. MR consistently showed improvement in marrow signal in Gaucher patients on enzyme therapy. As smaller doses of enzyme therapy are the trend, MR can be utilized to determine if therapy is effecting a change in the bone marrow. 1432-1998 14321998 Springer |
| shingle_catch_all_3 | Allison, J. W. James, Charles A. Arnold, G. L. Stine, Kimo C. Becton, David L. Bell, J. M. Reconversion of bone marrow in Gaucher disease treated with enzyme therapy documented by MR Abstract Background. Skeletal complications are responsible for significant morbidity in Gaucher patients. Plain radiographs have been unreliable in assessing bone marrow infiltration and activity. A way to assess bone marrow improvement is needed during enzyme therapy. Objective. The purpose of this paper is to assess the usefulness of MR in following improvement of abnormal bone marrow in Gaucher patients on enzyme therapy. Materials and methods. Three patients aged 2, 7, and 24 years underwent serial MR scans of the lower extremities before and during treatment with Alglucerase (two patients) and Imiglucerase (one patient). T1-weighted, T2-weighted, STIR and FSE T2-weighted images were utilized. Two patients were imaged after 16 months of therapy, and one patient was imaged after 6 months of therapy. Results. All patients had improvement in marrow signal consistent with partial reconversion to fatty marrow during treatment. The findings were more marked after prolonged therapy. T1-weighted images demonstrated findings most clearly. Conclusion. MR consistently showed improvement in marrow signal in Gaucher patients on enzyme therapy. As smaller doses of enzyme therapy are the trend, MR can be utilized to determine if therapy is effecting a change in the bone marrow. 1432-1998 14321998 Springer |
| shingle_catch_all_4 | Allison, J. W. James, Charles A. Arnold, G. L. Stine, Kimo C. Becton, David L. Bell, J. M. Reconversion of bone marrow in Gaucher disease treated with enzyme therapy documented by MR Abstract Background. Skeletal complications are responsible for significant morbidity in Gaucher patients. Plain radiographs have been unreliable in assessing bone marrow infiltration and activity. A way to assess bone marrow improvement is needed during enzyme therapy. Objective. The purpose of this paper is to assess the usefulness of MR in following improvement of abnormal bone marrow in Gaucher patients on enzyme therapy. Materials and methods. Three patients aged 2, 7, and 24 years underwent serial MR scans of the lower extremities before and during treatment with Alglucerase (two patients) and Imiglucerase (one patient). T1-weighted, T2-weighted, STIR and FSE T2-weighted images were utilized. Two patients were imaged after 16 months of therapy, and one patient was imaged after 6 months of therapy. Results. All patients had improvement in marrow signal consistent with partial reconversion to fatty marrow during treatment. The findings were more marked after prolonged therapy. T1-weighted images demonstrated findings most clearly. Conclusion. MR consistently showed improvement in marrow signal in Gaucher patients on enzyme therapy. As smaller doses of enzyme therapy are the trend, MR can be utilized to determine if therapy is effecting a change in the bone marrow. 1432-1998 14321998 Springer |
| shingle_title_1 | Reconversion of bone marrow in Gaucher disease treated with enzyme therapy documented by MR |
| shingle_title_2 | Reconversion of bone marrow in Gaucher disease treated with enzyme therapy documented by MR |
| shingle_title_3 | Reconversion of bone marrow in Gaucher disease treated with enzyme therapy documented by MR |
| shingle_title_4 | Reconversion of bone marrow in Gaucher disease treated with enzyme therapy documented by MR |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:43:09.163Z |
| titel | Reconversion of bone marrow in Gaucher disease treated with enzyme therapy documented by MR |
| titel_suche | Reconversion of bone marrow in Gaucher disease treated with enzyme therapy documented by MR |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM202644022 |