Correlation between clinical response and urinary interleukin levels using different doses and intravesical administration schedules of interferon-alpha-2b combined with epirubicin: a pilot study
Serretta, V. ; Corselli, G. ; Piazza, B. ; Lio, D. ; Gervasi, F. ; Salerno, S. ; Pavone-Macaluso, M.
Springer
Published 1993
Springer
Published 1993
| ISSN: |
1434-0879
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|---|---|
| Keywords: |
Intravesical chemotherapy ; Intravesical immunotherapy ; Interferon-alpha-2b ; Epirubicin ; Interleukins (urinary concentration of)
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Summary A total of 62 patients at high risk for recurrence of superficial bladder cancer were selected for a study designed to compare the prophylactic efficacy of different doses and schedules of sequential intravesical instillations of epirubicin and interferon-alpha-2b and to evaluate which sequence could enhance the release of cytokines in the urine. Our investigations showed a significant increase in urinary concentrations of interleukins in patients who received the sequential intravesical administration of epirubicin and interferon-alpha-2b. Higher urinary concentrations of interleukins and a lower recurrence rate were detected in patients who received interferon-alpha-2b 24 h after epirubicin instillation.
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| Type of Medium: |
Electronic Resource
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| URL: |