Incisional healing in rats treated with diethyl maleate
Yavuzer, R. ; Tascilar, Ö. ; Tekin, E. ; Latifoğlu, O. ; Akyol, G. ; Dursun, A. ; Taneri, F.
Springer
Published 1997
Springer
Published 1997
| ISSN: |
1435-0130
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|---|---|
| Keywords: |
Wound healing ; Diethyl maleate ; Tensile strength
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract Diethyl maleate (DEM) which binds and thus depletes tissue glutathione levels was used to aggravate the injury and to determine its effect on incisional healing. A 5 cm dorsal midline skin incision was performed on 40 albino Wistar rats in two groups and then closed by interrupted sutures. Groups received 0.9% NaCl and DEM at a dosage of 1 mg/kg/day intraperitoneally for seven days, respectively. On postoperative days 7 and 14, histopathological assessment and tensile strengths were measured. The DEM treated group had a marked inflammation with poorly defined collagen formation and the tensile strength measurements revealed a significant decrease (p 〈0.001) on the 7t day. On the other hand, the first group showed better collagenization and a lesser degree of inflammation. However, on the 14th day, there was no noticeable histopathological difference between the two groups; but, tensile strength values of the second group were still lower (p 〈0.05). In this animal model, DEM postponed the healing process and reduced the tensile strength.
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| Type of Medium: |
Electronic Resource
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| URL: |