Increased cerebral blood flow in MELAS shown by Tc-99m HMPAO brain SPECT
Peng, N. J. ; Liu, R. S. ; Li, J. Y. ; Tsay, D. G. ; Kong, K. W. ; Kwok, C. G. ; Strauss, H. W.
Springer
Published 2000
Springer
Published 2000
| ISSN: |
1432-1920
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|---|---|
| Keywords: |
Key words MELAS ; Single-photon emission computed tomography ; Cerebral blood flow
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract We report cerebral SPECT studies on two siblings with the syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Tc-99m HMPAO brain SPECT was performed 8, 19 and 30 days after a stroke-like episode in one case and 10 days after a stroke-like episode, 6 h after a partial seizure and as a follow-up study in the other. Increased blood flow was seen in both these patients with stroke-like episodes due to MELAS. The cause of the increased blood flow is uncertain, but it may be related to the decreased pH created by local increase in lactic acid.
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| Type of Medium: |
Electronic Resource
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| URL: |