MRI of growth hormone-secreting pituitary adenomas: factors determining pretreatment hormone levels

Saeki, N. ; Iuchi, T. ; Isono, S. ; Eda, M. ; Yamaura, A.
Springer
Published 1999
ISSN:
1432-1920
Keywords:
Key words Pituitary ; adenoma ; Growth hormone-secreting ; Acromegaly ; Magnetic resonance imaging
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Preoperative serum growth hormone (GH) level is one of the most important determinants of outcome. Our aim was to assess MRI findings which may correlate with pretreatment GH levels in GH-secreting adenomas. We retrospectively studied 29 patients with acromegaly caused by a pituitary adenoma. Tumor size (height, width, thickness and volume), suprasellar extension, sphenoid or cavernous sinus invasion, signal intensity and contrast enhancement were studied. Linear regression analysis or Fisher's exact probability test was used for statistical analysis. Factors related to high GH levels were the maximum dimension of the tumour (r = 0.496, P 〈 0.01), its volume (r = 0.439, P 〈 0.05), spenoid sinus invasion (P 〈 0.01) and intracavernous carotid artery (encasement (P 〈 0.01). The other items were not related to serum GH levels. Since we believe surgery is the first choice of treatment and the cavernous sinus is difficult of access with a conventional surgical approach, preoperative assessment of invasion into the cavernous sinus is critical for predicting the surgical outcome. Low GH levels (5–50 ng/ml) were found with tumours medial to the intercarotid line and high levels (more than 101 ng/ml) with invasive tumours with carotid artery encasement. Variable GH levels were noted with tumours extending beyond the intercarotid line. Because functioning adenomas invading the cavernous sinus tend to have markedly high hormone levels, and only patients with carotid artery encasement showed markedly elevated GH levels, we believe carotid artery encasement a reliable MRI indicator of cavernous sinus invasion.
Type of Medium:
Electronic Resource
URL:
_version_ 1798295855045804033
autor Saeki, N.
Iuchi, T.
Isono, S.
Eda, M.
Yamaura, A.
autorsonst Saeki, N.
Iuchi, T.
Isono, S.
Eda, M.
Yamaura, A.
book_url http://dx.doi.org/10.1007/s002340050839
datenlieferant nat_lic_papers
hauptsatz hsatz_simple
identnr NLM202559181
issn 1432-1920
journal_name Neuroradiology
materialart 1
notes Abstract Preoperative serum growth hormone (GH) level is one of the most important determinants of outcome. Our aim was to assess MRI findings which may correlate with pretreatment GH levels in GH-secreting adenomas. We retrospectively studied 29 patients with acromegaly caused by a pituitary adenoma. Tumor size (height, width, thickness and volume), suprasellar extension, sphenoid or cavernous sinus invasion, signal intensity and contrast enhancement were studied. Linear regression analysis or Fisher's exact probability test was used for statistical analysis. Factors related to high GH levels were the maximum dimension of the tumour (r = 0.496, P 〈 0.01), its volume (r = 0.439, P 〈 0.05), spenoid sinus invasion (P 〈 0.01) and intracavernous carotid artery (encasement (P 〈 0.01). The other items were not related to serum GH levels. Since we believe surgery is the first choice of treatment and the cavernous sinus is difficult of access with a conventional surgical approach, preoperative assessment of invasion into the cavernous sinus is critical for predicting the surgical outcome. Low GH levels (5–50 ng/ml) were found with tumours medial to the intercarotid line and high levels (more than 101 ng/ml) with invasive tumours with carotid artery encasement. Variable GH levels were noted with tumours extending beyond the intercarotid line. Because functioning adenomas invading the cavernous sinus tend to have markedly high hormone levels, and only patients with carotid artery encasement showed markedly elevated GH levels, we believe carotid artery encasement a reliable MRI indicator of cavernous sinus invasion.
package_name Springer
publikationsjahr_anzeige 1999
publikationsjahr_facette 1999
publikationsjahr_intervall 8004:1995-1999
publikationsjahr_sort 1999
publisher Springer
reference 41 (1999), S. 765-771
schlagwort Key words Pituitary
adenoma
Growth hormone-secreting
Acromegaly
Magnetic resonance imaging
search_space articles
shingle_author_1 Saeki, N.
Iuchi, T.
Isono, S.
Eda, M.
Yamaura, A.
shingle_author_2 Saeki, N.
Iuchi, T.
Isono, S.
Eda, M.
Yamaura, A.
shingle_author_3 Saeki, N.
Iuchi, T.
Isono, S.
Eda, M.
Yamaura, A.
shingle_author_4 Saeki, N.
Iuchi, T.
Isono, S.
Eda, M.
Yamaura, A.
shingle_catch_all_1 Saeki, N.
Iuchi, T.
Isono, S.
Eda, M.
Yamaura, A.
MRI of growth hormone-secreting pituitary adenomas: factors determining pretreatment hormone levels
Key words Pituitary
adenoma
Growth hormone-secreting
Acromegaly
Magnetic resonance imaging
Key words Pituitary
adenoma
Growth hormone-secreting
Acromegaly
Magnetic resonance imaging
Abstract Preoperative serum growth hormone (GH) level is one of the most important determinants of outcome. Our aim was to assess MRI findings which may correlate with pretreatment GH levels in GH-secreting adenomas. We retrospectively studied 29 patients with acromegaly caused by a pituitary adenoma. Tumor size (height, width, thickness and volume), suprasellar extension, sphenoid or cavernous sinus invasion, signal intensity and contrast enhancement were studied. Linear regression analysis or Fisher's exact probability test was used for statistical analysis. Factors related to high GH levels were the maximum dimension of the tumour (r = 0.496, P 〈 0.01), its volume (r = 0.439, P 〈 0.05), spenoid sinus invasion (P 〈 0.01) and intracavernous carotid artery (encasement (P 〈 0.01). The other items were not related to serum GH levels. Since we believe surgery is the first choice of treatment and the cavernous sinus is difficult of access with a conventional surgical approach, preoperative assessment of invasion into the cavernous sinus is critical for predicting the surgical outcome. Low GH levels (5–50 ng/ml) were found with tumours medial to the intercarotid line and high levels (more than 101 ng/ml) with invasive tumours with carotid artery encasement. Variable GH levels were noted with tumours extending beyond the intercarotid line. Because functioning adenomas invading the cavernous sinus tend to have markedly high hormone levels, and only patients with carotid artery encasement showed markedly elevated GH levels, we believe carotid artery encasement a reliable MRI indicator of cavernous sinus invasion.
1432-1920
14321920
Springer
shingle_catch_all_2 Saeki, N.
Iuchi, T.
Isono, S.
Eda, M.
Yamaura, A.
MRI of growth hormone-secreting pituitary adenomas: factors determining pretreatment hormone levels
Key words Pituitary
adenoma
Growth hormone-secreting
Acromegaly
Magnetic resonance imaging
Key words Pituitary
adenoma
Growth hormone-secreting
Acromegaly
Magnetic resonance imaging
Abstract Preoperative serum growth hormone (GH) level is one of the most important determinants of outcome. Our aim was to assess MRI findings which may correlate with pretreatment GH levels in GH-secreting adenomas. We retrospectively studied 29 patients with acromegaly caused by a pituitary adenoma. Tumor size (height, width, thickness and volume), suprasellar extension, sphenoid or cavernous sinus invasion, signal intensity and contrast enhancement were studied. Linear regression analysis or Fisher's exact probability test was used for statistical analysis. Factors related to high GH levels were the maximum dimension of the tumour (r = 0.496, P 〈 0.01), its volume (r = 0.439, P 〈 0.05), spenoid sinus invasion (P 〈 0.01) and intracavernous carotid artery (encasement (P 〈 0.01). The other items were not related to serum GH levels. Since we believe surgery is the first choice of treatment and the cavernous sinus is difficult of access with a conventional surgical approach, preoperative assessment of invasion into the cavernous sinus is critical for predicting the surgical outcome. Low GH levels (5–50 ng/ml) were found with tumours medial to the intercarotid line and high levels (more than 101 ng/ml) with invasive tumours with carotid artery encasement. Variable GH levels were noted with tumours extending beyond the intercarotid line. Because functioning adenomas invading the cavernous sinus tend to have markedly high hormone levels, and only patients with carotid artery encasement showed markedly elevated GH levels, we believe carotid artery encasement a reliable MRI indicator of cavernous sinus invasion.
1432-1920
14321920
Springer
shingle_catch_all_3 Saeki, N.
Iuchi, T.
Isono, S.
Eda, M.
Yamaura, A.
MRI of growth hormone-secreting pituitary adenomas: factors determining pretreatment hormone levels
Key words Pituitary
adenoma
Growth hormone-secreting
Acromegaly
Magnetic resonance imaging
Key words Pituitary
adenoma
Growth hormone-secreting
Acromegaly
Magnetic resonance imaging
Abstract Preoperative serum growth hormone (GH) level is one of the most important determinants of outcome. Our aim was to assess MRI findings which may correlate with pretreatment GH levels in GH-secreting adenomas. We retrospectively studied 29 patients with acromegaly caused by a pituitary adenoma. Tumor size (height, width, thickness and volume), suprasellar extension, sphenoid or cavernous sinus invasion, signal intensity and contrast enhancement were studied. Linear regression analysis or Fisher's exact probability test was used for statistical analysis. Factors related to high GH levels were the maximum dimension of the tumour (r = 0.496, P 〈 0.01), its volume (r = 0.439, P 〈 0.05), spenoid sinus invasion (P 〈 0.01) and intracavernous carotid artery (encasement (P 〈 0.01). The other items were not related to serum GH levels. Since we believe surgery is the first choice of treatment and the cavernous sinus is difficult of access with a conventional surgical approach, preoperative assessment of invasion into the cavernous sinus is critical for predicting the surgical outcome. Low GH levels (5–50 ng/ml) were found with tumours medial to the intercarotid line and high levels (more than 101 ng/ml) with invasive tumours with carotid artery encasement. Variable GH levels were noted with tumours extending beyond the intercarotid line. Because functioning adenomas invading the cavernous sinus tend to have markedly high hormone levels, and only patients with carotid artery encasement showed markedly elevated GH levels, we believe carotid artery encasement a reliable MRI indicator of cavernous sinus invasion.
1432-1920
14321920
Springer
shingle_catch_all_4 Saeki, N.
Iuchi, T.
Isono, S.
Eda, M.
Yamaura, A.
MRI of growth hormone-secreting pituitary adenomas: factors determining pretreatment hormone levels
Key words Pituitary
adenoma
Growth hormone-secreting
Acromegaly
Magnetic resonance imaging
Key words Pituitary
adenoma
Growth hormone-secreting
Acromegaly
Magnetic resonance imaging
Abstract Preoperative serum growth hormone (GH) level is one of the most important determinants of outcome. Our aim was to assess MRI findings which may correlate with pretreatment GH levels in GH-secreting adenomas. We retrospectively studied 29 patients with acromegaly caused by a pituitary adenoma. Tumor size (height, width, thickness and volume), suprasellar extension, sphenoid or cavernous sinus invasion, signal intensity and contrast enhancement were studied. Linear regression analysis or Fisher's exact probability test was used for statistical analysis. Factors related to high GH levels were the maximum dimension of the tumour (r = 0.496, P 〈 0.01), its volume (r = 0.439, P 〈 0.05), spenoid sinus invasion (P 〈 0.01) and intracavernous carotid artery (encasement (P 〈 0.01). The other items were not related to serum GH levels. Since we believe surgery is the first choice of treatment and the cavernous sinus is difficult of access with a conventional surgical approach, preoperative assessment of invasion into the cavernous sinus is critical for predicting the surgical outcome. Low GH levels (5–50 ng/ml) were found with tumours medial to the intercarotid line and high levels (more than 101 ng/ml) with invasive tumours with carotid artery encasement. Variable GH levels were noted with tumours extending beyond the intercarotid line. Because functioning adenomas invading the cavernous sinus tend to have markedly high hormone levels, and only patients with carotid artery encasement showed markedly elevated GH levels, we believe carotid artery encasement a reliable MRI indicator of cavernous sinus invasion.
1432-1920
14321920
Springer
shingle_title_1 MRI of growth hormone-secreting pituitary adenomas: factors determining pretreatment hormone levels
shingle_title_2 MRI of growth hormone-secreting pituitary adenomas: factors determining pretreatment hormone levels
shingle_title_3 MRI of growth hormone-secreting pituitary adenomas: factors determining pretreatment hormone levels
shingle_title_4 MRI of growth hormone-secreting pituitary adenomas: factors determining pretreatment hormone levels
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source_archive Springer Online Journal Archives 1860-2000
timestamp 2024-05-06T09:42:48.894Z
titel MRI of growth hormone-secreting pituitary adenomas: factors determining pretreatment hormone levels
titel_suche MRI of growth hormone-secreting pituitary adenomas: factors determining pretreatment hormone levels
topic WW-YZ
uid nat_lic_papers_NLM202559181