Prognostic value of proton MR spectroscopy of cerebral hemisphere tumors in children
Girard, N. ; Wang, Z. J. ; Erbetta, A. ; Sutton, L. N. ; Phillips, P. C. ; Rorke, L. B. ; Zimmerman, R. A.
Springer
Published 1998
Springer
Published 1998
| ISSN: |
1432-1920
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| Keywords: |
Key words Proton magnetic resonance spectroscopy ; Brain tumor ; pediatric ; Neuro-oncology ; Brain tumors ; prognosis
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract We studied 14 young people with newly diagnosed hemisphere tumors, aged from 3 to 20 years (average 10 years). All underwent surgery following MR imaging (MRI) and spectroscopy (MRS). The tumors studied were three glioblastomas, one each of ganglio-glioblastoma, primitive neuroectodermal tumor (PNET), rhabdoid teratoid tumor, pilocytic astrocytoma, ependymoma, anaplastic ependymoma, and gliomatosis cerebri, and four gangliogliomas. Four patients died; ten patients are alive (five with stable residual tumor, five with no evident tumor). Images and spectra were acquired on a 1.5-T imager. Proton MRS was performed before gadolinium injection in all but one case. Single-voxel techniques were utilized in all cases, using a spin-echo or STEAM sequence with a long echo time (135 or 270 ms). Peak areas of N -acetyl aspartate (NAA), choline (Cho), and creatine and phosphocreatine (Cr) were assessed. The NAA/Cho peak-area ratio was very low in the patients who died (mean ± s. d. 0.20 ± 0.14), and higher in the patients who are alive (0.74 ± 0.47; P = 0.007 by two-tailed t -test). The Cr/Cho peak-area ratio also followed a similar trend for the two groups (mean ± s. d. 0.17 ± 0.07 and 0.49 ± 0.30, respectively; P = 0.01 by two-tailed t -test).
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| Type of Medium: |
Electronic Resource
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| URL: |