Effects of dopamine on veins in humans: comparison with noradrenaline and influence of age
| ISSN: |
1432-1041
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| Keywords: |
Key words Noradrenaline ; Dopamine ; Venoconstriction
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Chemistry and Pharmacology
Medicine
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| Notes: |
Abstract Objective: To compare the venoconstricting effect of dopamine with that of noradrenaline and to investigate the influence of age on the responsiveness to dopamine in human subjects. Methods: In eight young and eight elderly male subjects, increasing doses of dopamine or noradrenaline were infused into a dorsal hand vein and its diameter was measured using a linear variable differential transformer. Results: There was no significant difference between the maximum venoconstriction (Emax) for dopamine and that for noradrenaline. The infusion rate to induce 50% of Emax (ED50) for dopamine in the young and elderly subjects was 363 ng · min−1 and 352 ng · min−1, and the ED50 for noradrenaline was 40.7 ng · min−1 and 43.8 ng · min−1, respectively. Neither in the Emax nor in the ED50 for these drugs were there significant differences between the young and elderly subjects. Conclusion: The venoconstricting effect of dopamine is 5–20 times less than that of noradrenaline, and aging does not influence the responsiveness to dopamine and noradrenaline in human subjects.
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| Type of Medium: |
Electronic Resource
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| URL: |