Single-dose pharmacokinetics of paracetamol and its conjugates in Chinese non-insulin-dependent diabetic patients with renal impairment
Chan, M. T. V. ; Anderson, P. J. ; Chan, J. C. N. ; Lau, G. S. N. ; Critchley, J. A. J. H.
Springer
Published 1997
Springer
Published 1997
| ISSN: |
1432-1041
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|---|---|
| Keywords: |
Key words Paracetamol ; Renal failure; polar conjugates ; non-insulin-dependent diabetes mellitus (NIDDM) ; pharmacokinetics
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Chemistry and Pharmacology
Medicine
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| Notes: |
Abstract Objective: A single oral dose of paracetamol (20 mg · kg−1) was given to 38 Chinese patients with non-insulin-dependent diabetes mellitus (NIDDM) who had either normal renal function or varying degrees of renal impairment, with creatinine clearances ranging from 4 to 123 ml · min−1 · 1.73 m−2. The plasma and urinary concentrations of paracetamol and its major metabolites were measured by high-performance liquid chromatography (HPLC). Results: The absorption and elimination of paracetamol were unaffected by renal impairment. However, the area under the plasma concentration time curve and the elimination half-life of paracetamol metabolites increased significantly with worsening renal insufficiency. Mean renal clearances of paracetamol and its conjugates were significantly reduced in these subjects. There was no evidence of altered metabolic activation with renal impairment. Conclusion: The results demonstrate that paracetamol disposition is minimally affected by diabetic nephropathy; however, extensive accumulation of conjugates may occur.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295570963496960 |
|---|---|
| autor | Chan, M. T. V. Anderson, P. J. Chan, J. C. N. Lau, G. S. N. Critchley, J. A. J. H. |
| autorsonst | Chan, M. T. V. Anderson, P. J. Chan, J. C. N. Lau, G. S. N. Critchley, J. A. J. H. |
| book_url | http://dx.doi.org/10.1007/s002280050291 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM20247707X |
| issn | 1432-1041 |
| journal_name | European journal of clinical pharmacology |
| materialart | 1 |
| notes | Abstract Objective: A single oral dose of paracetamol (20 mg · kg−1) was given to 38 Chinese patients with non-insulin-dependent diabetes mellitus (NIDDM) who had either normal renal function or varying degrees of renal impairment, with creatinine clearances ranging from 4 to 123 ml · min−1 · 1.73 m−2. The plasma and urinary concentrations of paracetamol and its major metabolites were measured by high-performance liquid chromatography (HPLC). Results: The absorption and elimination of paracetamol were unaffected by renal impairment. However, the area under the plasma concentration time curve and the elimination half-life of paracetamol metabolites increased significantly with worsening renal insufficiency. Mean renal clearances of paracetamol and its conjugates were significantly reduced in these subjects. There was no evidence of altered metabolic activation with renal impairment. Conclusion: The results demonstrate that paracetamol disposition is minimally affected by diabetic nephropathy; however, extensive accumulation of conjugates may occur. |
| package_name | Springer |
| publikationsjahr_anzeige | 1997 |
| publikationsjahr_facette | 1997 |
| publikationsjahr_intervall | 8004:1995-1999 |
| publikationsjahr_sort | 1997 |
| publisher | Springer |
| reference | 52 (1997), S. 285-288 |
| schlagwort | Key words Paracetamol Renal failure; polar conjugates non-insulin-dependent diabetes mellitus (NIDDM) pharmacokinetics |
| search_space | articles |
| shingle_author_1 | Chan, M. T. V. Anderson, P. J. Chan, J. C. N. Lau, G. S. N. Critchley, J. A. J. H. |
| shingle_author_2 | Chan, M. T. V. Anderson, P. J. Chan, J. C. N. Lau, G. S. N. Critchley, J. A. J. H. |
| shingle_author_3 | Chan, M. T. V. Anderson, P. J. Chan, J. C. N. Lau, G. S. N. Critchley, J. A. J. H. |
| shingle_author_4 | Chan, M. T. V. Anderson, P. J. Chan, J. C. N. Lau, G. S. N. Critchley, J. A. J. H. |
| shingle_catch_all_1 | Chan, M. T. V. Anderson, P. J. Chan, J. C. N. Lau, G. S. N. Critchley, J. A. J. H. Single-dose pharmacokinetics of paracetamol and its conjugates in Chinese non-insulin-dependent diabetic patients with renal impairment Key words Paracetamol Renal failure; polar conjugates non-insulin-dependent diabetes mellitus (NIDDM) pharmacokinetics Key words Paracetamol Renal failure; polar conjugates non-insulin-dependent diabetes mellitus (NIDDM) pharmacokinetics Abstract Objective: A single oral dose of paracetamol (20 mg · kg−1) was given to 38 Chinese patients with non-insulin-dependent diabetes mellitus (NIDDM) who had either normal renal function or varying degrees of renal impairment, with creatinine clearances ranging from 4 to 123 ml · min−1 · 1.73 m−2. The plasma and urinary concentrations of paracetamol and its major metabolites were measured by high-performance liquid chromatography (HPLC). Results: The absorption and elimination of paracetamol were unaffected by renal impairment. However, the area under the plasma concentration time curve and the elimination half-life of paracetamol metabolites increased significantly with worsening renal insufficiency. Mean renal clearances of paracetamol and its conjugates were significantly reduced in these subjects. There was no evidence of altered metabolic activation with renal impairment. Conclusion: The results demonstrate that paracetamol disposition is minimally affected by diabetic nephropathy; however, extensive accumulation of conjugates may occur. 1432-1041 14321041 Springer |
| shingle_catch_all_2 | Chan, M. T. V. Anderson, P. J. Chan, J. C. N. Lau, G. S. N. Critchley, J. A. J. H. Single-dose pharmacokinetics of paracetamol and its conjugates in Chinese non-insulin-dependent diabetic patients with renal impairment Key words Paracetamol Renal failure; polar conjugates non-insulin-dependent diabetes mellitus (NIDDM) pharmacokinetics Key words Paracetamol Renal failure; polar conjugates non-insulin-dependent diabetes mellitus (NIDDM) pharmacokinetics Abstract Objective: A single oral dose of paracetamol (20 mg · kg−1) was given to 38 Chinese patients with non-insulin-dependent diabetes mellitus (NIDDM) who had either normal renal function or varying degrees of renal impairment, with creatinine clearances ranging from 4 to 123 ml · min−1 · 1.73 m−2. The plasma and urinary concentrations of paracetamol and its major metabolites were measured by high-performance liquid chromatography (HPLC). Results: The absorption and elimination of paracetamol were unaffected by renal impairment. However, the area under the plasma concentration time curve and the elimination half-life of paracetamol metabolites increased significantly with worsening renal insufficiency. Mean renal clearances of paracetamol and its conjugates were significantly reduced in these subjects. There was no evidence of altered metabolic activation with renal impairment. Conclusion: The results demonstrate that paracetamol disposition is minimally affected by diabetic nephropathy; however, extensive accumulation of conjugates may occur. 1432-1041 14321041 Springer |
| shingle_catch_all_3 | Chan, M. T. V. Anderson, P. J. Chan, J. C. N. Lau, G. S. N. Critchley, J. A. J. H. Single-dose pharmacokinetics of paracetamol and its conjugates in Chinese non-insulin-dependent diabetic patients with renal impairment Key words Paracetamol Renal failure; polar conjugates non-insulin-dependent diabetes mellitus (NIDDM) pharmacokinetics Key words Paracetamol Renal failure; polar conjugates non-insulin-dependent diabetes mellitus (NIDDM) pharmacokinetics Abstract Objective: A single oral dose of paracetamol (20 mg · kg−1) was given to 38 Chinese patients with non-insulin-dependent diabetes mellitus (NIDDM) who had either normal renal function or varying degrees of renal impairment, with creatinine clearances ranging from 4 to 123 ml · min−1 · 1.73 m−2. The plasma and urinary concentrations of paracetamol and its major metabolites were measured by high-performance liquid chromatography (HPLC). Results: The absorption and elimination of paracetamol were unaffected by renal impairment. However, the area under the plasma concentration time curve and the elimination half-life of paracetamol metabolites increased significantly with worsening renal insufficiency. Mean renal clearances of paracetamol and its conjugates were significantly reduced in these subjects. There was no evidence of altered metabolic activation with renal impairment. Conclusion: The results demonstrate that paracetamol disposition is minimally affected by diabetic nephropathy; however, extensive accumulation of conjugates may occur. 1432-1041 14321041 Springer |
| shingle_catch_all_4 | Chan, M. T. V. Anderson, P. J. Chan, J. C. N. Lau, G. S. N. Critchley, J. A. J. H. Single-dose pharmacokinetics of paracetamol and its conjugates in Chinese non-insulin-dependent diabetic patients with renal impairment Key words Paracetamol Renal failure; polar conjugates non-insulin-dependent diabetes mellitus (NIDDM) pharmacokinetics Key words Paracetamol Renal failure; polar conjugates non-insulin-dependent diabetes mellitus (NIDDM) pharmacokinetics Abstract Objective: A single oral dose of paracetamol (20 mg · kg−1) was given to 38 Chinese patients with non-insulin-dependent diabetes mellitus (NIDDM) who had either normal renal function or varying degrees of renal impairment, with creatinine clearances ranging from 4 to 123 ml · min−1 · 1.73 m−2. The plasma and urinary concentrations of paracetamol and its major metabolites were measured by high-performance liquid chromatography (HPLC). Results: The absorption and elimination of paracetamol were unaffected by renal impairment. However, the area under the plasma concentration time curve and the elimination half-life of paracetamol metabolites increased significantly with worsening renal insufficiency. Mean renal clearances of paracetamol and its conjugates were significantly reduced in these subjects. There was no evidence of altered metabolic activation with renal impairment. Conclusion: The results demonstrate that paracetamol disposition is minimally affected by diabetic nephropathy; however, extensive accumulation of conjugates may occur. 1432-1041 14321041 Springer |
| shingle_title_1 | Single-dose pharmacokinetics of paracetamol and its conjugates in Chinese non-insulin-dependent diabetic patients with renal impairment |
| shingle_title_2 | Single-dose pharmacokinetics of paracetamol and its conjugates in Chinese non-insulin-dependent diabetic patients with renal impairment |
| shingle_title_3 | Single-dose pharmacokinetics of paracetamol and its conjugates in Chinese non-insulin-dependent diabetic patients with renal impairment |
| shingle_title_4 | Single-dose pharmacokinetics of paracetamol and its conjugates in Chinese non-insulin-dependent diabetic patients with renal impairment |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:38:19.269Z |
| titel | Single-dose pharmacokinetics of paracetamol and its conjugates in Chinese non-insulin-dependent diabetic patients with renal impairment |
| titel_suche | Single-dose pharmacokinetics of paracetamol and its conjugates in Chinese non-insulin-dependent diabetic patients with renal impairment |
| topic | V WW-YZ |
| uid | nat_lic_papers_NLM20247707X |