Effect of captopril on myocardial β-adrenoceptor density and Giα-proteins in patients with mild to moderate heart failure due to dilated cardiomyopathy
Jakob, H. ; Eschenhagen, T. ; Mende, U. ; Patten, M. ; Schmitz, W. ; Scholz, H. ; Schulte am Esch, J. ; Steinfath, M. ; Sigmund, M. ; Hanrath, P. ; Völker, H.
Springer
Published 1995
Springer
Published 1995
| ISSN: |
1432-1041
|
|---|---|
| Keywords: |
Captopril ; Dilated cardiomyopathy ; ACE-inhibitors ; G-proteins ; β-adrenoceptor density
|
| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Chemistry and Pharmacology
Medicine
|
| Notes: |
Abstract In end-stage heart failure due to idiopathic dilated cardiomyopathy β1-adrenoceptors are downregulated and G1α-proteins are upregulated. The aim of the present study was to investigate the influence of the angiotensin-converting enzyme inhibitor captopril on β-adrenoceptor density and Giα-proteins in sequential endomyocardial biopsies. Nineteen patients with mild to moderate congestive heart failure due to idiopathic dilated cardiomyopathy (NYHA Class II–III) were studied before and after 8–11 weeks of therapy. Patients were randomised into a captopril and a control group; 9 patients received captopril 12.5–50 mg per day, (divided in 2–3 doses) p.o. in addition to “conventional” therapy with digoxin and diuretics, and 10 controls received “conventional” therapy only. Echocardiography, spiroergometry, right heart catheterisation and endomyocardial biopsies were performed before (baseline) and after treatment. Compared to baseline, captopril increased total β-adrenoceptor density by selectively increasing β1-adrenoceptors (31.6 vs 41.2 fmol·mg−1; p〈0.05) but had no significant effect on Giα-proteins. The results indicate that treatment with angiotensin-converting enzyme inhibitors partly restores myocardial β1-adrenoceptor density, and this action effect may contribute to the clinical improvement of patients with idiopathic dilated cardiomyopathy treated in this way.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295570293456896 |
|---|---|
| autor | Jakob, H. Eschenhagen, T. Mende, U. Patten, M. Schmitz, W. Scholz, H. Schulte am Esch, J. Steinfath, M. Sigmund, M. Hanrath, P. Völker, H. |
| autorsonst | Jakob, H. Eschenhagen, T. Mende, U. Patten, M. Schmitz, W. Scholz, H. Schulte am Esch, J. Steinfath, M. Sigmund, M. Hanrath, P. Völker, H. |
| book_url | http://dx.doi.org/10.1007/BF00196850 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM202471624 |
| issn | 1432-1041 |
| journal_name | European journal of clinical pharmacology |
| materialart | 1 |
| notes | Abstract In end-stage heart failure due to idiopathic dilated cardiomyopathy β1-adrenoceptors are downregulated and G1α-proteins are upregulated. The aim of the present study was to investigate the influence of the angiotensin-converting enzyme inhibitor captopril on β-adrenoceptor density and Giα-proteins in sequential endomyocardial biopsies. Nineteen patients with mild to moderate congestive heart failure due to idiopathic dilated cardiomyopathy (NYHA Class II–III) were studied before and after 8–11 weeks of therapy. Patients were randomised into a captopril and a control group; 9 patients received captopril 12.5–50 mg per day, (divided in 2–3 doses) p.o. in addition to “conventional” therapy with digoxin and diuretics, and 10 controls received “conventional” therapy only. Echocardiography, spiroergometry, right heart catheterisation and endomyocardial biopsies were performed before (baseline) and after treatment. Compared to baseline, captopril increased total β-adrenoceptor density by selectively increasing β1-adrenoceptors (31.6 vs 41.2 fmol·mg−1; p〈0.05) but had no significant effect on Giα-proteins. The results indicate that treatment with angiotensin-converting enzyme inhibitors partly restores myocardial β1-adrenoceptor density, and this action effect may contribute to the clinical improvement of patients with idiopathic dilated cardiomyopathy treated in this way. |
| package_name | Springer |
| publikationsjahr_anzeige | 1995 |
| publikationsjahr_facette | 1995 |
| publikationsjahr_intervall | 8004:1995-1999 |
| publikationsjahr_sort | 1995 |
| publisher | Springer |
| reference | 47 (1995), S. 389-394 |
| schlagwort | Captopril Dilated cardiomyopathy ACE-inhibitors G-proteins β-adrenoceptor density |
| search_space | articles |
| shingle_author_1 | Jakob, H. Eschenhagen, T. Mende, U. Patten, M. Schmitz, W. Scholz, H. Schulte am Esch, J. Steinfath, M. Sigmund, M. Hanrath, P. Völker, H. |
| shingle_author_2 | Jakob, H. Eschenhagen, T. Mende, U. Patten, M. Schmitz, W. Scholz, H. Schulte am Esch, J. Steinfath, M. Sigmund, M. Hanrath, P. Völker, H. |
| shingle_author_3 | Jakob, H. Eschenhagen, T. Mende, U. Patten, M. Schmitz, W. Scholz, H. Schulte am Esch, J. Steinfath, M. Sigmund, M. Hanrath, P. Völker, H. |
| shingle_author_4 | Jakob, H. Eschenhagen, T. Mende, U. Patten, M. Schmitz, W. Scholz, H. Schulte am Esch, J. Steinfath, M. Sigmund, M. Hanrath, P. Völker, H. |
| shingle_catch_all_1 | Jakob, H. Eschenhagen, T. Mende, U. Patten, M. Schmitz, W. Scholz, H. Schulte am Esch, J. Steinfath, M. Sigmund, M. Hanrath, P. Völker, H. Effect of captopril on myocardial β-adrenoceptor density and Giα-proteins in patients with mild to moderate heart failure due to dilated cardiomyopathy Captopril Dilated cardiomyopathy ACE-inhibitors G-proteins β-adrenoceptor density Captopril Dilated cardiomyopathy ACE-inhibitors G-proteins β-adrenoceptor density Abstract In end-stage heart failure due to idiopathic dilated cardiomyopathy β1-adrenoceptors are downregulated and G1α-proteins are upregulated. The aim of the present study was to investigate the influence of the angiotensin-converting enzyme inhibitor captopril on β-adrenoceptor density and Giα-proteins in sequential endomyocardial biopsies. Nineteen patients with mild to moderate congestive heart failure due to idiopathic dilated cardiomyopathy (NYHA Class II–III) were studied before and after 8–11 weeks of therapy. Patients were randomised into a captopril and a control group; 9 patients received captopril 12.5–50 mg per day, (divided in 2–3 doses) p.o. in addition to “conventional” therapy with digoxin and diuretics, and 10 controls received “conventional” therapy only. Echocardiography, spiroergometry, right heart catheterisation and endomyocardial biopsies were performed before (baseline) and after treatment. Compared to baseline, captopril increased total β-adrenoceptor density by selectively increasing β1-adrenoceptors (31.6 vs 41.2 fmol·mg−1; p〈0.05) but had no significant effect on Giα-proteins. The results indicate that treatment with angiotensin-converting enzyme inhibitors partly restores myocardial β1-adrenoceptor density, and this action effect may contribute to the clinical improvement of patients with idiopathic dilated cardiomyopathy treated in this way. 1432-1041 14321041 Springer |
| shingle_catch_all_2 | Jakob, H. Eschenhagen, T. Mende, U. Patten, M. Schmitz, W. Scholz, H. Schulte am Esch, J. Steinfath, M. Sigmund, M. Hanrath, P. Völker, H. Effect of captopril on myocardial β-adrenoceptor density and Giα-proteins in patients with mild to moderate heart failure due to dilated cardiomyopathy Captopril Dilated cardiomyopathy ACE-inhibitors G-proteins β-adrenoceptor density Captopril Dilated cardiomyopathy ACE-inhibitors G-proteins β-adrenoceptor density Abstract In end-stage heart failure due to idiopathic dilated cardiomyopathy β1-adrenoceptors are downregulated and G1α-proteins are upregulated. The aim of the present study was to investigate the influence of the angiotensin-converting enzyme inhibitor captopril on β-adrenoceptor density and Giα-proteins in sequential endomyocardial biopsies. Nineteen patients with mild to moderate congestive heart failure due to idiopathic dilated cardiomyopathy (NYHA Class II–III) were studied before and after 8–11 weeks of therapy. Patients were randomised into a captopril and a control group; 9 patients received captopril 12.5–50 mg per day, (divided in 2–3 doses) p.o. in addition to “conventional” therapy with digoxin and diuretics, and 10 controls received “conventional” therapy only. Echocardiography, spiroergometry, right heart catheterisation and endomyocardial biopsies were performed before (baseline) and after treatment. Compared to baseline, captopril increased total β-adrenoceptor density by selectively increasing β1-adrenoceptors (31.6 vs 41.2 fmol·mg−1; p〈0.05) but had no significant effect on Giα-proteins. The results indicate that treatment with angiotensin-converting enzyme inhibitors partly restores myocardial β1-adrenoceptor density, and this action effect may contribute to the clinical improvement of patients with idiopathic dilated cardiomyopathy treated in this way. 1432-1041 14321041 Springer |
| shingle_catch_all_3 | Jakob, H. Eschenhagen, T. Mende, U. Patten, M. Schmitz, W. Scholz, H. Schulte am Esch, J. Steinfath, M. Sigmund, M. Hanrath, P. Völker, H. Effect of captopril on myocardial β-adrenoceptor density and Giα-proteins in patients with mild to moderate heart failure due to dilated cardiomyopathy Captopril Dilated cardiomyopathy ACE-inhibitors G-proteins β-adrenoceptor density Captopril Dilated cardiomyopathy ACE-inhibitors G-proteins β-adrenoceptor density Abstract In end-stage heart failure due to idiopathic dilated cardiomyopathy β1-adrenoceptors are downregulated and G1α-proteins are upregulated. The aim of the present study was to investigate the influence of the angiotensin-converting enzyme inhibitor captopril on β-adrenoceptor density and Giα-proteins in sequential endomyocardial biopsies. Nineteen patients with mild to moderate congestive heart failure due to idiopathic dilated cardiomyopathy (NYHA Class II–III) were studied before and after 8–11 weeks of therapy. Patients were randomised into a captopril and a control group; 9 patients received captopril 12.5–50 mg per day, (divided in 2–3 doses) p.o. in addition to “conventional” therapy with digoxin and diuretics, and 10 controls received “conventional” therapy only. Echocardiography, spiroergometry, right heart catheterisation and endomyocardial biopsies were performed before (baseline) and after treatment. Compared to baseline, captopril increased total β-adrenoceptor density by selectively increasing β1-adrenoceptors (31.6 vs 41.2 fmol·mg−1; p〈0.05) but had no significant effect on Giα-proteins. The results indicate that treatment with angiotensin-converting enzyme inhibitors partly restores myocardial β1-adrenoceptor density, and this action effect may contribute to the clinical improvement of patients with idiopathic dilated cardiomyopathy treated in this way. 1432-1041 14321041 Springer |
| shingle_catch_all_4 | Jakob, H. Eschenhagen, T. Mende, U. Patten, M. Schmitz, W. Scholz, H. Schulte am Esch, J. Steinfath, M. Sigmund, M. Hanrath, P. Völker, H. Effect of captopril on myocardial β-adrenoceptor density and Giα-proteins in patients with mild to moderate heart failure due to dilated cardiomyopathy Captopril Dilated cardiomyopathy ACE-inhibitors G-proteins β-adrenoceptor density Captopril Dilated cardiomyopathy ACE-inhibitors G-proteins β-adrenoceptor density Abstract In end-stage heart failure due to idiopathic dilated cardiomyopathy β1-adrenoceptors are downregulated and G1α-proteins are upregulated. The aim of the present study was to investigate the influence of the angiotensin-converting enzyme inhibitor captopril on β-adrenoceptor density and Giα-proteins in sequential endomyocardial biopsies. Nineteen patients with mild to moderate congestive heart failure due to idiopathic dilated cardiomyopathy (NYHA Class II–III) were studied before and after 8–11 weeks of therapy. Patients were randomised into a captopril and a control group; 9 patients received captopril 12.5–50 mg per day, (divided in 2–3 doses) p.o. in addition to “conventional” therapy with digoxin and diuretics, and 10 controls received “conventional” therapy only. Echocardiography, spiroergometry, right heart catheterisation and endomyocardial biopsies were performed before (baseline) and after treatment. Compared to baseline, captopril increased total β-adrenoceptor density by selectively increasing β1-adrenoceptors (31.6 vs 41.2 fmol·mg−1; p〈0.05) but had no significant effect on Giα-proteins. The results indicate that treatment with angiotensin-converting enzyme inhibitors partly restores myocardial β1-adrenoceptor density, and this action effect may contribute to the clinical improvement of patients with idiopathic dilated cardiomyopathy treated in this way. 1432-1041 14321041 Springer |
| shingle_title_1 | Effect of captopril on myocardial β-adrenoceptor density and Giα-proteins in patients with mild to moderate heart failure due to dilated cardiomyopathy |
| shingle_title_2 | Effect of captopril on myocardial β-adrenoceptor density and Giα-proteins in patients with mild to moderate heart failure due to dilated cardiomyopathy |
| shingle_title_3 | Effect of captopril on myocardial β-adrenoceptor density and Giα-proteins in patients with mild to moderate heart failure due to dilated cardiomyopathy |
| shingle_title_4 | Effect of captopril on myocardial β-adrenoceptor density and Giα-proteins in patients with mild to moderate heart failure due to dilated cardiomyopathy |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:38:18.370Z |
| titel | Effect of captopril on myocardial β-adrenoceptor density and Giα-proteins in patients with mild to moderate heart failure due to dilated cardiomyopathy |
| titel_suche | Effect of captopril on myocardial β-adrenoceptor density and Giα-proteins in patients with mild to moderate heart failure due to dilated cardiomyopathy |
| topic | V WW-YZ |
| uid | nat_lic_papers_NLM202471624 |