Removal of famotidine by haemodialysis in elderly anuric patients
Inotsume, N. ; Nishimura, M. ; Nakano, M. ; Fujiyama, S. ; Sagara, K. ; Sato, T. ; Matsushita, K. ; Imai, Y. ; Matsui, H.
Springer
Published 1990
Springer
Published 1990
| ISSN: |
1432-1041
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|---|---|
| Keywords: |
famotidine ; anuric patients ; haemodialysis ; H2-receptor antagonist ; pharmacokinetics
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Chemistry and Pharmacology
Medicine
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| Notes: |
Summary The effect of haemodialysis on the pharmacokinetics of oral famotidine has been studied in five elderly anuric patients. Famotidine 20 mg was administered in a cross-over design to patients on and not on haemodialysis. The elimination rate constant of haemodialysis (k) was 4.6-fold larger than the systemic elimination rate constant (ke). Although the mean maximum serum concentration of famotidine during haemodialysis (141.5 ng·ml−1) was not significantly lower than that without haemodialysis (195.6 ng·ml−1), the AUC up to 5 h during haemodialysis was significantly decreased to 58.1% of the value without it. The data suggest that famotidine is dialysable by haemodialysis.
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| Type of Medium: |
Electronic Resource
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| URL: |