Pharmacokinetics of streptomycin in Ethiopian children with tuberculosis and of different nutritional status
| ISSN: |
1432-1041
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|---|---|
| Keywords: |
streptomycin ; tuberculosis ; malnutrition ; pharmacokinetics ; children
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Chemistry and Pharmacology
Medicine
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| Notes: |
Summary Fifty-six malnourished Ethiopian children with tuberculosis classified in four nutrional groups (normal, underweight, marasmus and kwashiorkor), were given streptomycin 20 or 30 mg·kg−1 i.m. The plasma concentration-time data revealed an increased apparent volume of distribution in children with kwashiorkor compared to normals. The total plasma clearance was low and did not differ between the nutrional groups. Thus, the half-life was prolonged only in kwashiorkor. The results could be explained by decreased protein binding in plasma and decreased renal clearance by glomerular filtration.
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| Type of Medium: |
Electronic Resource
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| URL: |