Time-course of the anti-hypertensive action of atenolol: Comparison of response to first dose and to maintained oral administration

Leonetti, G. ; Terzoli, L. ; Bianchini, C. ; Sala, C. ; Zanchetti, A.
Springer
Published 1980
ISSN:
1432-1041
Keywords:
atenolol ; hypertension ; plasma renin activity ; pharmacokinetics ; pharmacodynamic effects
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Medicine
Notes:
Summary To show whether repeated administration of atenolol for several days would influence its pharmacokinetic parameters and the extent and duration of the pharmacologic responses, the plasma level of atenolol and changes in heart rate, blood pressure and plasma renin activity were measured in 12 hypertensive patients at various times of day (9 a. m., 12 noon, 3 p. m. and 7 p. m.) after oral administration of the first dose of atenolol 100 mg, again during the 7th and 14th days of continued once-daily administration of the same dose, and finally during the three days following withdrawal of the drug. The peak plasma concentration of atenolol (about 600 ng/ml) was found 3 h after administration of the first dose, and measurable amounts (50–70 ng/ml) were found after 24 h. None of the pharmacokinetic characteristics were changed by administration of a single daily dose for two weeks. After withdrawal of the drug, detectable amounts of atenolol were found in plasma for at least 48 h. The first dose of atenolol caused prompt (3 h) and prolonged (up to 24 h) lowering of supine and standing systolic and diastolic blood pressures, slowing of supine and standing heart rate, reduction of the blood pressure and heart rate responses to dynamic exercise, and a decrease in plasma renin activity. The extent and time-course of all these responses were not influenced by repeated once-daily administration of the 100 mg dose for two weeks. Most of the effects continued during the withdrawal days, the lowering of blood pressure being somewhat more prolonged than the slowing of heart rate. It is concluded that a once-daily dose of atenolol 100 mg decreases blood pressure and heart rate throughout the following 24 h, without excessive daily fluctuation in its effects, and without signs of tolerance or accumulation.
Type of Medium:
Electronic Resource
URL:
_version_ 1798295564756975617
autor Leonetti, G.
Terzoli, L.
Bianchini, C.
Sala, C.
Zanchetti, A.
autorsonst Leonetti, G.
Terzoli, L.
Bianchini, C.
Sala, C.
Zanchetti, A.
book_url http://dx.doi.org/10.1007/BF00636787
datenlieferant nat_lic_papers
hauptsatz hsatz_simple
identnr NLM202433285
issn 1432-1041
journal_name European journal of clinical pharmacology
materialart 1
notes Summary To show whether repeated administration of atenolol for several days would influence its pharmacokinetic parameters and the extent and duration of the pharmacologic responses, the plasma level of atenolol and changes in heart rate, blood pressure and plasma renin activity were measured in 12 hypertensive patients at various times of day (9 a. m., 12 noon, 3 p. m. and 7 p. m.) after oral administration of the first dose of atenolol 100 mg, again during the 7th and 14th days of continued once-daily administration of the same dose, and finally during the three days following withdrawal of the drug. The peak plasma concentration of atenolol (about 600 ng/ml) was found 3 h after administration of the first dose, and measurable amounts (50–70 ng/ml) were found after 24 h. None of the pharmacokinetic characteristics were changed by administration of a single daily dose for two weeks. After withdrawal of the drug, detectable amounts of atenolol were found in plasma for at least 48 h. The first dose of atenolol caused prompt (3 h) and prolonged (up to 24 h) lowering of supine and standing systolic and diastolic blood pressures, slowing of supine and standing heart rate, reduction of the blood pressure and heart rate responses to dynamic exercise, and a decrease in plasma renin activity. The extent and time-course of all these responses were not influenced by repeated once-daily administration of the 100 mg dose for two weeks. Most of the effects continued during the withdrawal days, the lowering of blood pressure being somewhat more prolonged than the slowing of heart rate. It is concluded that a once-daily dose of atenolol 100 mg decreases blood pressure and heart rate throughout the following 24 h, without excessive daily fluctuation in its effects, and without signs of tolerance or accumulation.
package_name Springer
publikationsjahr_anzeige 1980
publikationsjahr_facette 1980
publikationsjahr_intervall 8019:1980-1984
publikationsjahr_sort 1980
publisher Springer
reference 18 (1980), S. 365-374
schlagwort atenolol
hypertension
plasma renin activity
pharmacokinetics
pharmacodynamic effects
search_space articles
shingle_author_1 Leonetti, G.
Terzoli, L.
Bianchini, C.
Sala, C.
Zanchetti, A.
shingle_author_2 Leonetti, G.
Terzoli, L.
Bianchini, C.
Sala, C.
Zanchetti, A.
shingle_author_3 Leonetti, G.
Terzoli, L.
Bianchini, C.
Sala, C.
Zanchetti, A.
shingle_author_4 Leonetti, G.
Terzoli, L.
Bianchini, C.
Sala, C.
Zanchetti, A.
shingle_catch_all_1 Leonetti, G.
Terzoli, L.
Bianchini, C.
Sala, C.
Zanchetti, A.
Time-course of the anti-hypertensive action of atenolol: Comparison of response to first dose and to maintained oral administration
atenolol
hypertension
plasma renin activity
pharmacokinetics
pharmacodynamic effects
atenolol
hypertension
plasma renin activity
pharmacokinetics
pharmacodynamic effects
Summary To show whether repeated administration of atenolol for several days would influence its pharmacokinetic parameters and the extent and duration of the pharmacologic responses, the plasma level of atenolol and changes in heart rate, blood pressure and plasma renin activity were measured in 12 hypertensive patients at various times of day (9 a. m., 12 noon, 3 p. m. and 7 p. m.) after oral administration of the first dose of atenolol 100 mg, again during the 7th and 14th days of continued once-daily administration of the same dose, and finally during the three days following withdrawal of the drug. The peak plasma concentration of atenolol (about 600 ng/ml) was found 3 h after administration of the first dose, and measurable amounts (50–70 ng/ml) were found after 24 h. None of the pharmacokinetic characteristics were changed by administration of a single daily dose for two weeks. After withdrawal of the drug, detectable amounts of atenolol were found in plasma for at least 48 h. The first dose of atenolol caused prompt (3 h) and prolonged (up to 24 h) lowering of supine and standing systolic and diastolic blood pressures, slowing of supine and standing heart rate, reduction of the blood pressure and heart rate responses to dynamic exercise, and a decrease in plasma renin activity. The extent and time-course of all these responses were not influenced by repeated once-daily administration of the 100 mg dose for two weeks. Most of the effects continued during the withdrawal days, the lowering of blood pressure being somewhat more prolonged than the slowing of heart rate. It is concluded that a once-daily dose of atenolol 100 mg decreases blood pressure and heart rate throughout the following 24 h, without excessive daily fluctuation in its effects, and without signs of tolerance or accumulation.
1432-1041
14321041
Springer
shingle_catch_all_2 Leonetti, G.
Terzoli, L.
Bianchini, C.
Sala, C.
Zanchetti, A.
Time-course of the anti-hypertensive action of atenolol: Comparison of response to first dose and to maintained oral administration
atenolol
hypertension
plasma renin activity
pharmacokinetics
pharmacodynamic effects
atenolol
hypertension
plasma renin activity
pharmacokinetics
pharmacodynamic effects
Summary To show whether repeated administration of atenolol for several days would influence its pharmacokinetic parameters and the extent and duration of the pharmacologic responses, the plasma level of atenolol and changes in heart rate, blood pressure and plasma renin activity were measured in 12 hypertensive patients at various times of day (9 a. m., 12 noon, 3 p. m. and 7 p. m.) after oral administration of the first dose of atenolol 100 mg, again during the 7th and 14th days of continued once-daily administration of the same dose, and finally during the three days following withdrawal of the drug. The peak plasma concentration of atenolol (about 600 ng/ml) was found 3 h after administration of the first dose, and measurable amounts (50–70 ng/ml) were found after 24 h. None of the pharmacokinetic characteristics were changed by administration of a single daily dose for two weeks. After withdrawal of the drug, detectable amounts of atenolol were found in plasma for at least 48 h. The first dose of atenolol caused prompt (3 h) and prolonged (up to 24 h) lowering of supine and standing systolic and diastolic blood pressures, slowing of supine and standing heart rate, reduction of the blood pressure and heart rate responses to dynamic exercise, and a decrease in plasma renin activity. The extent and time-course of all these responses were not influenced by repeated once-daily administration of the 100 mg dose for two weeks. Most of the effects continued during the withdrawal days, the lowering of blood pressure being somewhat more prolonged than the slowing of heart rate. It is concluded that a once-daily dose of atenolol 100 mg decreases blood pressure and heart rate throughout the following 24 h, without excessive daily fluctuation in its effects, and without signs of tolerance or accumulation.
1432-1041
14321041
Springer
shingle_catch_all_3 Leonetti, G.
Terzoli, L.
Bianchini, C.
Sala, C.
Zanchetti, A.
Time-course of the anti-hypertensive action of atenolol: Comparison of response to first dose and to maintained oral administration
atenolol
hypertension
plasma renin activity
pharmacokinetics
pharmacodynamic effects
atenolol
hypertension
plasma renin activity
pharmacokinetics
pharmacodynamic effects
Summary To show whether repeated administration of atenolol for several days would influence its pharmacokinetic parameters and the extent and duration of the pharmacologic responses, the plasma level of atenolol and changes in heart rate, blood pressure and plasma renin activity were measured in 12 hypertensive patients at various times of day (9 a. m., 12 noon, 3 p. m. and 7 p. m.) after oral administration of the first dose of atenolol 100 mg, again during the 7th and 14th days of continued once-daily administration of the same dose, and finally during the three days following withdrawal of the drug. The peak plasma concentration of atenolol (about 600 ng/ml) was found 3 h after administration of the first dose, and measurable amounts (50–70 ng/ml) were found after 24 h. None of the pharmacokinetic characteristics were changed by administration of a single daily dose for two weeks. After withdrawal of the drug, detectable amounts of atenolol were found in plasma for at least 48 h. The first dose of atenolol caused prompt (3 h) and prolonged (up to 24 h) lowering of supine and standing systolic and diastolic blood pressures, slowing of supine and standing heart rate, reduction of the blood pressure and heart rate responses to dynamic exercise, and a decrease in plasma renin activity. The extent and time-course of all these responses were not influenced by repeated once-daily administration of the 100 mg dose for two weeks. Most of the effects continued during the withdrawal days, the lowering of blood pressure being somewhat more prolonged than the slowing of heart rate. It is concluded that a once-daily dose of atenolol 100 mg decreases blood pressure and heart rate throughout the following 24 h, without excessive daily fluctuation in its effects, and without signs of tolerance or accumulation.
1432-1041
14321041
Springer
shingle_catch_all_4 Leonetti, G.
Terzoli, L.
Bianchini, C.
Sala, C.
Zanchetti, A.
Time-course of the anti-hypertensive action of atenolol: Comparison of response to first dose and to maintained oral administration
atenolol
hypertension
plasma renin activity
pharmacokinetics
pharmacodynamic effects
atenolol
hypertension
plasma renin activity
pharmacokinetics
pharmacodynamic effects
Summary To show whether repeated administration of atenolol for several days would influence its pharmacokinetic parameters and the extent and duration of the pharmacologic responses, the plasma level of atenolol and changes in heart rate, blood pressure and plasma renin activity were measured in 12 hypertensive patients at various times of day (9 a. m., 12 noon, 3 p. m. and 7 p. m.) after oral administration of the first dose of atenolol 100 mg, again during the 7th and 14th days of continued once-daily administration of the same dose, and finally during the three days following withdrawal of the drug. The peak plasma concentration of atenolol (about 600 ng/ml) was found 3 h after administration of the first dose, and measurable amounts (50–70 ng/ml) were found after 24 h. None of the pharmacokinetic characteristics were changed by administration of a single daily dose for two weeks. After withdrawal of the drug, detectable amounts of atenolol were found in plasma for at least 48 h. The first dose of atenolol caused prompt (3 h) and prolonged (up to 24 h) lowering of supine and standing systolic and diastolic blood pressures, slowing of supine and standing heart rate, reduction of the blood pressure and heart rate responses to dynamic exercise, and a decrease in plasma renin activity. The extent and time-course of all these responses were not influenced by repeated once-daily administration of the 100 mg dose for two weeks. Most of the effects continued during the withdrawal days, the lowering of blood pressure being somewhat more prolonged than the slowing of heart rate. It is concluded that a once-daily dose of atenolol 100 mg decreases blood pressure and heart rate throughout the following 24 h, without excessive daily fluctuation in its effects, and without signs of tolerance or accumulation.
1432-1041
14321041
Springer
shingle_title_1 Time-course of the anti-hypertensive action of atenolol: Comparison of response to first dose and to maintained oral administration
shingle_title_2 Time-course of the anti-hypertensive action of atenolol: Comparison of response to first dose and to maintained oral administration
shingle_title_3 Time-course of the anti-hypertensive action of atenolol: Comparison of response to first dose and to maintained oral administration
shingle_title_4 Time-course of the anti-hypertensive action of atenolol: Comparison of response to first dose and to maintained oral administration
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timestamp 2024-05-06T09:38:13.157Z
titel Time-course of the anti-hypertensive action of atenolol: Comparison of response to first dose and to maintained oral administration
titel_suche Time-course of the anti-hypertensive action of atenolol: Comparison of response to first dose and to maintained oral administration
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