The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man
Reid, J. L. ; Porsius, A. J. ; Zamboulis, C. ; Polak, G. ; Hamilton, C. A. ; Dean, C. R.
Springer
Published 1979
Springer
Published 1979
ISSN: |
1432-1041
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Keywords: |
methyldopa ; hypotension ; tricyclic antidepressants ; drug interactions
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Source: |
Springer Online Journal Archives 1860-2000
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Topics: |
Chemistry and Pharmacology
Medicine
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Notes: |
Summary The effect of pretreatment with the tricyclic antidepressant desmethylimipramine (DMI) 75 mg daily for 3 days on the action of oral methyldopa 750 mg was investigated in a double blind crossover design in volunteers. DMI pretreatment caused a small but not significant increase in supine systolic and diastolic blood pressure and heart rate. However, the effects of methyldopa on lying and standing blood pressure and heart rate were not markedly altered by pretreatment. In particular, the fall in standing blood pressure after methyldopa was present with and without DMI and the sedative action of methyldopa was similar. DMI alone reduced saliva production. No evidence was found that tricyclic antidepressant drugs significantly modify the hypotensive effect of methyldopa in man.
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Type of Medium: |
Electronic Resource
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URL: |
_version_ | 1798295564894339072 |
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autor | Reid, J. L. Porsius, A. J. Zamboulis, C. Polak, G. Hamilton, C. A. Dean, C. R. |
autorsonst | Reid, J. L. Porsius, A. J. Zamboulis, C. Polak, G. Hamilton, C. A. Dean, C. R. |
book_url | http://dx.doi.org/10.1007/BF00563110 |
datenlieferant | nat_lic_papers |
hauptsatz | hsatz_simple |
identnr | NLM202431290 |
issn | 1432-1041 |
journal_name | European journal of clinical pharmacology |
materialart | 1 |
notes | Summary The effect of pretreatment with the tricyclic antidepressant desmethylimipramine (DMI) 75 mg daily for 3 days on the action of oral methyldopa 750 mg was investigated in a double blind crossover design in volunteers. DMI pretreatment caused a small but not significant increase in supine systolic and diastolic blood pressure and heart rate. However, the effects of methyldopa on lying and standing blood pressure and heart rate were not markedly altered by pretreatment. In particular, the fall in standing blood pressure after methyldopa was present with and without DMI and the sedative action of methyldopa was similar. DMI alone reduced saliva production. No evidence was found that tricyclic antidepressant drugs significantly modify the hypotensive effect of methyldopa in man. |
package_name | Springer |
publikationsjahr_anzeige | 1979 |
publikationsjahr_facette | 1979 |
publikationsjahr_intervall | 8024:1975-1979 |
publikationsjahr_sort | 1979 |
publisher | Springer |
reference | 16 (1979), S. 75-80 |
schlagwort | methyldopa hypotension tricyclic antidepressants drug interactions |
search_space | articles |
shingle_author_1 | Reid, J. L. Porsius, A. J. Zamboulis, C. Polak, G. Hamilton, C. A. Dean, C. R. |
shingle_author_2 | Reid, J. L. Porsius, A. J. Zamboulis, C. Polak, G. Hamilton, C. A. Dean, C. R. |
shingle_author_3 | Reid, J. L. Porsius, A. J. Zamboulis, C. Polak, G. Hamilton, C. A. Dean, C. R. |
shingle_author_4 | Reid, J. L. Porsius, A. J. Zamboulis, C. Polak, G. Hamilton, C. A. Dean, C. R. |
shingle_catch_all_1 | Reid, J. L. Porsius, A. J. Zamboulis, C. Polak, G. Hamilton, C. A. Dean, C. R. The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man methyldopa hypotension tricyclic antidepressants drug interactions methyldopa hypotension tricyclic antidepressants drug interactions Summary The effect of pretreatment with the tricyclic antidepressant desmethylimipramine (DMI) 75 mg daily for 3 days on the action of oral methyldopa 750 mg was investigated in a double blind crossover design in volunteers. DMI pretreatment caused a small but not significant increase in supine systolic and diastolic blood pressure and heart rate. However, the effects of methyldopa on lying and standing blood pressure and heart rate were not markedly altered by pretreatment. In particular, the fall in standing blood pressure after methyldopa was present with and without DMI and the sedative action of methyldopa was similar. DMI alone reduced saliva production. No evidence was found that tricyclic antidepressant drugs significantly modify the hypotensive effect of methyldopa in man. 1432-1041 14321041 Springer |
shingle_catch_all_2 | Reid, J. L. Porsius, A. J. Zamboulis, C. Polak, G. Hamilton, C. A. Dean, C. R. The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man methyldopa hypotension tricyclic antidepressants drug interactions methyldopa hypotension tricyclic antidepressants drug interactions Summary The effect of pretreatment with the tricyclic antidepressant desmethylimipramine (DMI) 75 mg daily for 3 days on the action of oral methyldopa 750 mg was investigated in a double blind crossover design in volunteers. DMI pretreatment caused a small but not significant increase in supine systolic and diastolic blood pressure and heart rate. However, the effects of methyldopa on lying and standing blood pressure and heart rate were not markedly altered by pretreatment. In particular, the fall in standing blood pressure after methyldopa was present with and without DMI and the sedative action of methyldopa was similar. DMI alone reduced saliva production. No evidence was found that tricyclic antidepressant drugs significantly modify the hypotensive effect of methyldopa in man. 1432-1041 14321041 Springer |
shingle_catch_all_3 | Reid, J. L. Porsius, A. J. Zamboulis, C. Polak, G. Hamilton, C. A. Dean, C. R. The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man methyldopa hypotension tricyclic antidepressants drug interactions methyldopa hypotension tricyclic antidepressants drug interactions Summary The effect of pretreatment with the tricyclic antidepressant desmethylimipramine (DMI) 75 mg daily for 3 days on the action of oral methyldopa 750 mg was investigated in a double blind crossover design in volunteers. DMI pretreatment caused a small but not significant increase in supine systolic and diastolic blood pressure and heart rate. However, the effects of methyldopa on lying and standing blood pressure and heart rate were not markedly altered by pretreatment. In particular, the fall in standing blood pressure after methyldopa was present with and without DMI and the sedative action of methyldopa was similar. DMI alone reduced saliva production. No evidence was found that tricyclic antidepressant drugs significantly modify the hypotensive effect of methyldopa in man. 1432-1041 14321041 Springer |
shingle_catch_all_4 | Reid, J. L. Porsius, A. J. Zamboulis, C. Polak, G. Hamilton, C. A. Dean, C. R. The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man methyldopa hypotension tricyclic antidepressants drug interactions methyldopa hypotension tricyclic antidepressants drug interactions Summary The effect of pretreatment with the tricyclic antidepressant desmethylimipramine (DMI) 75 mg daily for 3 days on the action of oral methyldopa 750 mg was investigated in a double blind crossover design in volunteers. DMI pretreatment caused a small but not significant increase in supine systolic and diastolic blood pressure and heart rate. However, the effects of methyldopa on lying and standing blood pressure and heart rate were not markedly altered by pretreatment. In particular, the fall in standing blood pressure after methyldopa was present with and without DMI and the sedative action of methyldopa was similar. DMI alone reduced saliva production. No evidence was found that tricyclic antidepressant drugs significantly modify the hypotensive effect of methyldopa in man. 1432-1041 14321041 Springer |
shingle_title_1 | The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man |
shingle_title_2 | The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man |
shingle_title_3 | The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man |
shingle_title_4 | The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man |
sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
source_archive | Springer Online Journal Archives 1860-2000 |
timestamp | 2024-05-06T09:38:12.780Z |
titel | The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man |
titel_suche | The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man |
topic | V WW-YZ |
uid | nat_lic_papers_NLM202431290 |