The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man

ISSN:
1432-1041
Keywords:
methyldopa ; hypotension ; tricyclic antidepressants ; drug interactions
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Medicine
Notes:
Summary The effect of pretreatment with the tricyclic antidepressant desmethylimipramine (DMI) 75 mg daily for 3 days on the action of oral methyldopa 750 mg was investigated in a double blind crossover design in volunteers. DMI pretreatment caused a small but not significant increase in supine systolic and diastolic blood pressure and heart rate. However, the effects of methyldopa on lying and standing blood pressure and heart rate were not markedly altered by pretreatment. In particular, the fall in standing blood pressure after methyldopa was present with and without DMI and the sedative action of methyldopa was similar. DMI alone reduced saliva production. No evidence was found that tricyclic antidepressant drugs significantly modify the hypotensive effect of methyldopa in man.
Type of Medium:
Electronic Resource
URL:
_version_ 1798295564894339072
autor Reid, J. L.
Porsius, A. J.
Zamboulis, C.
Polak, G.
Hamilton, C. A.
Dean, C. R.
autorsonst Reid, J. L.
Porsius, A. J.
Zamboulis, C.
Polak, G.
Hamilton, C. A.
Dean, C. R.
book_url http://dx.doi.org/10.1007/BF00563110
datenlieferant nat_lic_papers
hauptsatz hsatz_simple
identnr NLM202431290
issn 1432-1041
journal_name European journal of clinical pharmacology
materialart 1
notes Summary The effect of pretreatment with the tricyclic antidepressant desmethylimipramine (DMI) 75 mg daily for 3 days on the action of oral methyldopa 750 mg was investigated in a double blind crossover design in volunteers. DMI pretreatment caused a small but not significant increase in supine systolic and diastolic blood pressure and heart rate. However, the effects of methyldopa on lying and standing blood pressure and heart rate were not markedly altered by pretreatment. In particular, the fall in standing blood pressure after methyldopa was present with and without DMI and the sedative action of methyldopa was similar. DMI alone reduced saliva production. No evidence was found that tricyclic antidepressant drugs significantly modify the hypotensive effect of methyldopa in man.
package_name Springer
publikationsjahr_anzeige 1979
publikationsjahr_facette 1979
publikationsjahr_intervall 8024:1975-1979
publikationsjahr_sort 1979
publisher Springer
reference 16 (1979), S. 75-80
schlagwort methyldopa
hypotension
tricyclic antidepressants
drug interactions
search_space articles
shingle_author_1 Reid, J. L.
Porsius, A. J.
Zamboulis, C.
Polak, G.
Hamilton, C. A.
Dean, C. R.
shingle_author_2 Reid, J. L.
Porsius, A. J.
Zamboulis, C.
Polak, G.
Hamilton, C. A.
Dean, C. R.
shingle_author_3 Reid, J. L.
Porsius, A. J.
Zamboulis, C.
Polak, G.
Hamilton, C. A.
Dean, C. R.
shingle_author_4 Reid, J. L.
Porsius, A. J.
Zamboulis, C.
Polak, G.
Hamilton, C. A.
Dean, C. R.
shingle_catch_all_1 Reid, J. L.
Porsius, A. J.
Zamboulis, C.
Polak, G.
Hamilton, C. A.
Dean, C. R.
The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man
methyldopa
hypotension
tricyclic antidepressants
drug interactions
methyldopa
hypotension
tricyclic antidepressants
drug interactions
Summary The effect of pretreatment with the tricyclic antidepressant desmethylimipramine (DMI) 75 mg daily for 3 days on the action of oral methyldopa 750 mg was investigated in a double blind crossover design in volunteers. DMI pretreatment caused a small but not significant increase in supine systolic and diastolic blood pressure and heart rate. However, the effects of methyldopa on lying and standing blood pressure and heart rate were not markedly altered by pretreatment. In particular, the fall in standing blood pressure after methyldopa was present with and without DMI and the sedative action of methyldopa was similar. DMI alone reduced saliva production. No evidence was found that tricyclic antidepressant drugs significantly modify the hypotensive effect of methyldopa in man.
1432-1041
14321041
Springer
shingle_catch_all_2 Reid, J. L.
Porsius, A. J.
Zamboulis, C.
Polak, G.
Hamilton, C. A.
Dean, C. R.
The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man
methyldopa
hypotension
tricyclic antidepressants
drug interactions
methyldopa
hypotension
tricyclic antidepressants
drug interactions
Summary The effect of pretreatment with the tricyclic antidepressant desmethylimipramine (DMI) 75 mg daily for 3 days on the action of oral methyldopa 750 mg was investigated in a double blind crossover design in volunteers. DMI pretreatment caused a small but not significant increase in supine systolic and diastolic blood pressure and heart rate. However, the effects of methyldopa on lying and standing blood pressure and heart rate were not markedly altered by pretreatment. In particular, the fall in standing blood pressure after methyldopa was present with and without DMI and the sedative action of methyldopa was similar. DMI alone reduced saliva production. No evidence was found that tricyclic antidepressant drugs significantly modify the hypotensive effect of methyldopa in man.
1432-1041
14321041
Springer
shingle_catch_all_3 Reid, J. L.
Porsius, A. J.
Zamboulis, C.
Polak, G.
Hamilton, C. A.
Dean, C. R.
The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man
methyldopa
hypotension
tricyclic antidepressants
drug interactions
methyldopa
hypotension
tricyclic antidepressants
drug interactions
Summary The effect of pretreatment with the tricyclic antidepressant desmethylimipramine (DMI) 75 mg daily for 3 days on the action of oral methyldopa 750 mg was investigated in a double blind crossover design in volunteers. DMI pretreatment caused a small but not significant increase in supine systolic and diastolic blood pressure and heart rate. However, the effects of methyldopa on lying and standing blood pressure and heart rate were not markedly altered by pretreatment. In particular, the fall in standing blood pressure after methyldopa was present with and without DMI and the sedative action of methyldopa was similar. DMI alone reduced saliva production. No evidence was found that tricyclic antidepressant drugs significantly modify the hypotensive effect of methyldopa in man.
1432-1041
14321041
Springer
shingle_catch_all_4 Reid, J. L.
Porsius, A. J.
Zamboulis, C.
Polak, G.
Hamilton, C. A.
Dean, C. R.
The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man
methyldopa
hypotension
tricyclic antidepressants
drug interactions
methyldopa
hypotension
tricyclic antidepressants
drug interactions
Summary The effect of pretreatment with the tricyclic antidepressant desmethylimipramine (DMI) 75 mg daily for 3 days on the action of oral methyldopa 750 mg was investigated in a double blind crossover design in volunteers. DMI pretreatment caused a small but not significant increase in supine systolic and diastolic blood pressure and heart rate. However, the effects of methyldopa on lying and standing blood pressure and heart rate were not markedly altered by pretreatment. In particular, the fall in standing blood pressure after methyldopa was present with and without DMI and the sedative action of methyldopa was similar. DMI alone reduced saliva production. No evidence was found that tricyclic antidepressant drugs significantly modify the hypotensive effect of methyldopa in man.
1432-1041
14321041
Springer
shingle_title_1 The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man
shingle_title_2 The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man
shingle_title_3 The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man
shingle_title_4 The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man
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source_archive Springer Online Journal Archives 1860-2000
timestamp 2024-05-06T09:38:12.780Z
titel The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man
titel_suche The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man
topic V
WW-YZ
uid nat_lic_papers_NLM202431290